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Protein
Submitted name:

26S proteasome regulatory complex subunit p39A

Gene

Rpn9

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.4.25.1 1994
ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-216167 Nuclear CI is degraded
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-432395 Degradation of TIM
R-DME-432524 Degradation of PER
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-538848 Degradation of CLK
R-DME-538864 Degradation of CRY
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-6798695 Neutrophil degranulation
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p39AImported
Submitted name:
LD17530pImported
Submitted name:
Regulatory particle non-ATPase 9, isoform AImported
Submitted name:
Regulatory particle non-ATPase 9, isoform BImported
Gene namesi
Name:Rpn9Imported
Synonyms:06Imported, 0718Imported, 718Imported, CT28749Imported, Dmel\CG10230Imported, l(3)S071806Imported, l(3)S071806bImported, p39AImported, PSMD13Imported, Rpn4Imported, rpn9Imported, Rpn94Imported, S11Imported
ORF Names:CG10230Imported, Dmel_CG10230Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028691 Rpn9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

PRIDEiQ7KMP8

Expressioni

Gene expression databases

BgeeiFBgn0028691

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rpn8P262703EBI-151692,EBI-253612

Protein-protein interaction databases

IntActiQ7KMP8, 10 interactors
STRINGi7227.FBpp0083860

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 343PCIInterPro annotationAdd BLAST170

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 154Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2908 Eukaryota
ENOG410XPG9 LUCA
GeneTreeiENSGT00390000001802
KOiK03039
OMAiKFADKIN
OrthoDBiEOG091G0977

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR035298 PSMD13
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10539 PTHR10539, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KMP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPQPNVTA YLATQKKTTN KELAAEWTLI EELYNEKLWN ELTIKLVTFV
60 70 80 90 100
RHESLQDETA LLQLYQNFLS TFETKINPYG LIQILEVVVD NIGDKKEAIE
110 120 130 140 150
FLEKMKDKVK ICDEAVWYLQ VMQGNLYLSN LNDLNATKKI IEELRDVLEE
160 170 180 190 200
AGNVTPVHGK YYMLASQYYR RVGKHSDYYR CGLQFLGCSM DEYPRDQWAQ
210 220 230 240 250
QAFFLGLAAL LGDGVYNIGE LLAHPILESL KGTENEWLME LLKAFNTGDI
260 270 280 290 300
NKFNDMKKIW SKIPDLAAQE VKLRQKISLL CLMEMTFKRS AIERAISFTD
310 320 330 340 350
IAQETKLPAK EVELLIMKAL ALDLVRGEID QVAGVVNMSW VQPRVLNRSQ
360 370 380
IVGMASTLDT WMGAITNMEK LMENRAAEIL TN
Length:382
Mass (Da):43,767
Last modified:October 3, 2006 - v1
Checksum:i096A8AB66C505D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145311 mRNA Translation: AAF08392.1
AE014297 Genomic DNA Translation: AAF56173.1
AE014297 Genomic DNA Translation: AAF56174.1
AY061232 mRNA Translation: AAL28780.1
RefSeqiNP_651177.1, NM_142920.3
NP_732899.1, NM_170088.2
UniGeneiDm.3423

Genome annotation databases

EnsemblMetazoaiFBtr0084469; FBpp0083860; FBgn0028691
FBtr0084470; FBpp0083861; FBgn0028691
GeneIDi42802
KEGGidme:Dmel_CG10230
UCSCiCG10230-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ7KMP8_DROME
AccessioniPrimary (citable) accession number: Q7KMP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 18, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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