UniProtKB - Q7KIN0 (TOLL7_DROME)
Toll-like receptor 7
Toll-7
Functioni
Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553).
Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169).
This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169).
Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726).
Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726).
Also involved in the targeting of other classes of ORN axons (PubMed:25741726).
Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553).
May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
4 PublicationsCaution
GO - Molecular functioni
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
- neurotrophin receptor activity Source: FlyBase
- pattern recognition receptor activity Source: FlyBase
- transmembrane signaling receptor activity Source: FlyBase
- virion binding Source: FlyBase
GO - Biological processi
- axon guidance Source: FlyBase
- cell surface pattern recognition receptor signaling pathway Source: FlyBase
- defense response to virus Source: FlyBase
- detection of virus Source: FlyBase
- innate immune response Source: FlyBase
- positive regulation of antimicrobial peptide production Source: FlyBase
- positive regulation of autophagy Source: FlyBase
- regulation of defense response to virus Source: FlyBase
- Toll signaling pathway Source: FlyBase
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Immunity, Innate immunity |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-DME-193634, Axonal growth inhibition (RHOA activation) R-DME-977606, Regulation of Complement cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Toll-like receptor 7Curated |
Gene namesi | Name:Toll-7Imported ORF Names:CG8595Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034476, Toll-7 |
VEuPathDBi | VectorBase:FBgn0034476 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: FlyBase
- integral component of plasma membrane Source: FlyBase
Other locations
- extracellular matrix Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 1049 | ExtracellularCuratedAdd BLAST | 1033 | |
Transmembranei | 1050 – 1070 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1071 – 1446 | CytoplasmicCuratedAdd BLAST | 376 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5006489795 | 17 – 1446 | Toll-like receptor 7Add BLAST | 1430 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 722 ↔ 772 | By similarity | ||
Disulfide bondi | 796 ↔ 802 | By similarity | ||
Disulfide bondi | 800 ↔ 815 | By similarity | ||
Disulfide bondi | 966 ↔ 993 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q7KIN0 |
PTM databases
SwissPalmi | Q7KIN0 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | FBgn0034476, Expressed in central nervous system and 31 other tissues |
ExpressionAtlasi | Q7KIN0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 133 – 156 | LRR 1Sequence analysisAdd BLAST | 24 | |
Repeati | 158 – 180 | LRR 2Sequence analysisAdd BLAST | 23 | |
Repeati | 188 – 211 | LRR 3Sequence analysisAdd BLAST | 24 | |
Repeati | 213 – 235 | LRR 4Sequence analysisAdd BLAST | 23 | |
Repeati | 246 – 270 | LRR 5Sequence analysisAdd BLAST | 25 | |
Repeati | 271 – 294 | LRR 6Sequence analysisAdd BLAST | 24 | |
Repeati | 295 – 318 | LRR 7Sequence analysisAdd BLAST | 24 | |
Repeati | 320 – 342 | LRR 8Sequence analysisAdd BLAST | 23 | |
Repeati | 344 – 368 | LRR 9Sequence analysisAdd BLAST | 25 | |
Repeati | 369 – 392 | LRR 10Sequence analysisAdd BLAST | 24 | |
Repeati | 393 – 416 | LRR 11Sequence analysisAdd BLAST | 24 | |
Repeati | 417 – 440 | LRR 12Sequence analysisAdd BLAST | 24 | |
Repeati | 442 – 464 | LRR 13Sequence analysisAdd BLAST | 23 | |
Repeati | 465 – 488 | LRR 14Sequence analysisAdd BLAST | 24 | |
Repeati | 489 – 511 | LRR 15Sequence analysisAdd BLAST | 23 | |
Repeati | 513 – 535 | LRR 16Sequence analysisAdd BLAST | 23 | |
Repeati | 536 – 559 | LRR 17Sequence analysisAdd BLAST | 24 | |
Repeati | 561 – 582 | LRR 18Sequence analysisAdd BLAST | 22 | |
Repeati | 584 – 605 | LRR 19Sequence analysisAdd BLAST | 22 | |
Repeati | 606 – 629 | LRR 20Sequence analysisAdd BLAST | 24 | |
Repeati | 631 – 652 | LRR 21Sequence analysisAdd BLAST | 22 | |
Repeati | 653 – 675 | LRR 22Sequence analysisAdd BLAST | 23 | |
Repeati | 677 – 699 | LRR 23Sequence analysisAdd BLAST | 23 | |
Domaini | 716 – 773 | LRRCTSequence analysisAdd BLAST | 58 | |
Repeati | 828 – 851 | LRR 24Sequence analysisAdd BLAST | 24 | |
Repeati | 852 – 875 | LRR 25Sequence analysisAdd BLAST | 24 | |
Repeati | 876 – 899 | LRR 26Sequence analysisAdd BLAST | 24 | |
Repeati | 900 – 923 | LRR 27Sequence analysisAdd BLAST | 24 | |
Repeati | 925 – 947 | LRR 28Sequence analysisAdd BLAST | 23 | |
Repeati | 951 – 979 | LRR 29Sequence analysisAdd BLAST | 29 | |
Domaini | 1096 – 1233 | TIRPROSITE-ProRule annotationAdd BLAST | 138 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1301 – 1332 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1388 – 1446 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1301 – 1323 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1391 – 1440 | Polar residuesSequence analysisAdd BLAST | 50 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000159318 |
HOGENOMi | CLU_004280_0_0_1 |
InParanoidi | Q7KIN0 |
OMAi | EWARCEL |
OrthoDBi | 60380at2759 |
PhylomeDBi | Q7KIN0 |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
Pfami | View protein in Pfam PF00560, LRR_1, 1 hit PF13855, LRR_8, 6 hits PF13676, TIR_2, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 20 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 23 hits PS50104, TIR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY
60 70 80 90 100
SSLLSNVPAA SPVPANPSQP SGPANQCSWS YNGTSSVHCA LRLIERQPGL
110 120 130 140 150
DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LDSCKLLQLP
160 170 180 190 200
NNAFEGLATL KSLRLSTHNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN
210 220 230 240 250
LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ MGFADMNCGA GSGSAGSELQ
260 270 280 290 300
VLDASHNELR SISESWGISR LRRLQHLNLA YNNLSELSGE ALAGLASLRI
310 320 330 340 350
VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD
360 370 380 390 400
LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN
410 420 430 440 450
LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN
460 470 480 490 500
NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ
510 520 530 540 550
IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ
560 570 580 590 600
SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD
610 620 630 640 650
YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS
660 670 680 690 700
IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA
710 720 730 740 750
PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV
760 770 780 790 800
MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC
810 820 830 840 850
TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI
860 870 880 890 900
GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL
910 920 930 940 950
SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF
960 970 980 990 1000
GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT
1010 1020 1030 1040 1050
GSAALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL
1060 1070 1080 1090 1100
LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA
1110 1120 1130 1140 1150
VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR
1160 1170 1180 1190 1200
VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA
1210 1220 1230 1240 1250
ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD
1260 1270 1280 1290 1300
HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE
1310 1320 1330 1340 1350
QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY
1360 1370 1380 1390 1400
SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA AQRAQTWRPK REQLHLQQAQ
1410 1420 1430 1440
AGTLGSKASQ AAHQQQQQQQ QQQQQQPNPT AVSGQQQGPH VQAYLV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | P → L in ABA86520 (PubMed:16120803).Curated | 1 | |
Sequence conflicti | 124 | T → K in ABA86520 (PubMed:16120803).Curated | 1 | |
Sequence conflicti | 1426 | Missing in ABA86520 (PubMed:16120803).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF247765 mRNA Translation: AAF86225.1 DQ138914 Genomic DNA Translation: ABA86520.1 AE013599 Genomic DNA Translation: AAF57514.1 BT125656 mRNA Translation: ADN32842.1 |
RefSeqi | NP_523797.1, NM_079073.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0086336; FBpp0085638; FBgn0034476 |
GeneIDi | 37272 |
KEGGi | dme:Dmel_CG8595 |
UCSCi | CG8595-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF247765 mRNA Translation: AAF86225.1 DQ138914 Genomic DNA Translation: ABA86520.1 AE013599 Genomic DNA Translation: AAF57514.1 BT125656 mRNA Translation: ADN32842.1 |
RefSeqi | NP_523797.1, NM_079073.3 |
3D structure databases
AlphaFoldDBi | Q7KIN0 |
SMRi | Q7KIN0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0085638 |
PTM databases
SwissPalmi | Q7KIN0 |
Proteomic databases
PaxDbi | Q7KIN0 |
Genome annotation databases
EnsemblMetazoai | FBtr0086336; FBpp0085638; FBgn0034476 |
GeneIDi | 37272 |
KEGGi | dme:Dmel_CG8595 |
UCSCi | CG8595-RA, d. melanogaster |
Organism-specific databases
CTDi | 37272 |
FlyBasei | FBgn0034476, Toll-7 |
VEuPathDBi | VectorBase:FBgn0034476 |
Phylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000159318 |
HOGENOMi | CLU_004280_0_0_1 |
InParanoidi | Q7KIN0 |
OMAi | EWARCEL |
OrthoDBi | 60380at2759 |
PhylomeDBi | Q7KIN0 |
Enzyme and pathway databases
Reactomei | R-DME-193634, Axonal growth inhibition (RHOA activation) R-DME-977606, Regulation of Complement cascade |
Miscellaneous databases
BioGRID-ORCSi | 37272, 0 hits in 1 CRISPR screen |
GenomeRNAii | 37272 |
PROi | PR:Q7KIN0 |
Gene expression databases
Bgeei | FBgn0034476, Expressed in central nervous system and 31 other tissues |
ExpressionAtlasi | Q7KIN0, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
Pfami | View protein in Pfam PF00560, LRR_1, 1 hit PF13855, LRR_8, 6 hits PF13676, TIR_2, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 20 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 23 hits PS50104, TIR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TOLL7_DROME | |
Accessioni | Q7KIN0Primary (citable) accession number: Q7KIN0 Secondary accession number(s): E1NZA7, Q2XXU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 6, 2016 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families