Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q7KIN0 (TOLL7_DROME)

Entry version 145 (25 May 2022)
Sequence version 1 (03 Oct 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Toll-like receptor 7

Gene

Toll-7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553).

Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169).

This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169).

Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726).

Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726).

Also involved in the targeting of other classes of ORN axons (PubMed:25741726).

Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553).

May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).

4 Publications

Caution

In some plant proteins and in human SARM1, the TIR domain has NAD+ hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.By similarityCurated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processImmunity, Innate immunity
LigandNAD

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-193634, Axonal growth inhibition (RHOA activation)
R-DME-977606, Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 7Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Toll-7Imported
ORF Names:CG8595Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0034476, Toll-7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0034476

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 1049ExtracellularCuratedAdd BLAST1033
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1050 – 1070HelicalSequence analysisAdd BLAST21
Topological domaini1071 – 1446CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mistargeting of VA1d ORN axons to a medial position (PubMed:25741726). No effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). RNAi-mediated knockdown results in adults that are acutely sensitive to the vesicular stomatitis virus (vsv) (PubMed:22464169). Following infection with vsv adult survival is decreased, and adults show a dramatic increase in viral RNA production 6 days post vsv infection and viral replication 9 days post infection (PubMed:22464169). Reduced autophagy in adult fat body cells following vsv infection (PubMed:22464169). Starvation-induced autophagy is not affected (PubMed:22464169).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500648979517 – 1446Toll-like receptor 7Add BLAST1430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi722 ↔ 772By similarity
Disulfide bondi796 ↔ 802By similarity
Disulfide bondi800 ↔ 815By similarity
Disulfide bondi966 ↔ 993By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7KIN0

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7KIN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the fan-shaped body and the ellipsoid body, which are components of the locomotion center in the CNS (at protein level) (PubMed:23892553).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryos, expressed in the ventral neurons, motor neurons and in the longitudinal interneuron axons (at protein level) (PubMed:23892553). May also be expressed in the motor neuron dendrites or possibly the glia (at protein level) (PubMed:23892553). Expressed 48 hours after puparium formation in the lateral glomeruli of the anterior and central regions of the antennal lobe, including the DA1, VA1d and VA1v glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At germ band extension, expressed as 14 stripes in the embryo (PubMed:12617819). At germ band retraction, expressed in a subset of neurons in the CNS, the precursors of the leg imaginal disks and in the ventral epithelium of the large intestine (PubMed:12617819). Expressed in the posterior and anterior spiracles (PubMed:12617819). In stage 16 embryos, expression decreases and is mainly localized to the CNS (PubMed:12617819). Expressed in the proximal region of the wing imaginal disks, around the wing pouch and hinge regions (PubMed:21158756). Also expressed in the distal segments of the leg imaginal disks, with high levels of expression around the A-P border of the tarsal to tibia segments (PubMed:21158756). In larvae, detected in the fat body (PubMed:12617819).5 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during vesicular stomatitis virus (VSV) infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0034476, Expressed in central nervous system and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7KIN0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0085638

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q7KIN0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7KIN0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 156LRR 1Sequence analysisAdd BLAST24
Repeati158 – 180LRR 2Sequence analysisAdd BLAST23
Repeati188 – 211LRR 3Sequence analysisAdd BLAST24
Repeati213 – 235LRR 4Sequence analysisAdd BLAST23
Repeati246 – 270LRR 5Sequence analysisAdd BLAST25
Repeati271 – 294LRR 6Sequence analysisAdd BLAST24
Repeati295 – 318LRR 7Sequence analysisAdd BLAST24
Repeati320 – 342LRR 8Sequence analysisAdd BLAST23
Repeati344 – 368LRR 9Sequence analysisAdd BLAST25
Repeati369 – 392LRR 10Sequence analysisAdd BLAST24
Repeati393 – 416LRR 11Sequence analysisAdd BLAST24
Repeati417 – 440LRR 12Sequence analysisAdd BLAST24
Repeati442 – 464LRR 13Sequence analysisAdd BLAST23
Repeati465 – 488LRR 14Sequence analysisAdd BLAST24
Repeati489 – 511LRR 15Sequence analysisAdd BLAST23
Repeati513 – 535LRR 16Sequence analysisAdd BLAST23
Repeati536 – 559LRR 17Sequence analysisAdd BLAST24
Repeati561 – 582LRR 18Sequence analysisAdd BLAST22
Repeati584 – 605LRR 19Sequence analysisAdd BLAST22
Repeati606 – 629LRR 20Sequence analysisAdd BLAST24
Repeati631 – 652LRR 21Sequence analysisAdd BLAST22
Repeati653 – 675LRR 22Sequence analysisAdd BLAST23
Repeati677 – 699LRR 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini716 – 773LRRCTSequence analysisAdd BLAST58
Repeati828 – 851LRR 24Sequence analysisAdd BLAST24
Repeati852 – 875LRR 25Sequence analysisAdd BLAST24
Repeati876 – 899LRR 26Sequence analysisAdd BLAST24
Repeati900 – 923LRR 27Sequence analysisAdd BLAST24
Repeati925 – 947LRR 28Sequence analysisAdd BLAST23
Repeati951 – 979LRR 29Sequence analysisAdd BLAST29
Domaini1096 – 1233TIRPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1301 – 1332DisorderedSequence analysisAdd BLAST32
Regioni1388 – 1446DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1301 – 1323Polar residuesSequence analysisAdd BLAST23
Compositional biasi1391 – 1440Polar residuesSequence analysisAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4641, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004280_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7KIN0

Identification of Orthologs from Complete Genome Data

More...OMAi		EWARCEL

Database of Orthologous Groups

More...OrthoDBi		60380at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7KIN0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10140, 1 hit
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00560, LRR_1, 1 hit
PF13855, LRR_8, 6 hits
PF13676, TIR_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 20 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52200, SSF52200, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 23 hits
PS50104, TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7KIN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY 
        60         70         80         90        100
SSLLSNVPAA SPVPANPSQP SGPANQCSWS YNGTSSVHCA LRLIERQPGL 
       110        120        130        140        150
DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LDSCKLLQLP 
       160        170        180        190        200
NNAFEGLATL KSLRLSTHNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN 
       210        220        230        240        250
LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ MGFADMNCGA GSGSAGSELQ 
       260        270        280        290        300
VLDASHNELR SISESWGISR LRRLQHLNLA YNNLSELSGE ALAGLASLRI 
       310        320        330        340        350
VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD 
       360        370        380        390        400
LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN 
       410        420        430        440        450
LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN 
       460        470        480        490        500
NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ 
       510        520        530        540        550
IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ 
       560        570        580        590        600
SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD 
       610        620        630        640        650
YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS 
       660        670        680        690        700
IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA 
       710        720        730        740        750
PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV 
       760        770        780        790        800
MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC 
       810        820        830        840        850
TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI 
       860        870        880        890        900
GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL 
       910        920        930        940        950
SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF 
       960        970        980        990       1000
GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT 
      1010       1020       1030       1040       1050
GSAALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL 
      1060       1070       1080       1090       1100
LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA 
      1110       1120       1130       1140       1150
VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR 
      1160       1170       1180       1190       1200
VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA 
      1210       1220       1230       1240       1250
ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD 
      1260       1270       1280       1290       1300
HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE 
      1310       1320       1330       1340       1350
QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY 
      1360       1370       1380       1390       1400
SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA AQRAQTWRPK REQLHLQQAQ 
      1410       1420       1430       1440 
AGTLGSKASQ AAHQQQQQQQ QQQQQQPNPT AVSGQQQGPH VQAYLV
Length:1,446
Mass (Da):160,950
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80D281BDA9500ABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58P → L in ABA86520 (PubMed:16120803).Curated1
Sequence conflicti124T → K in ABA86520 (PubMed:16120803).Curated1
Sequence conflicti1426Missing in ABA86520 (PubMed:16120803).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF247765 mRNA Translation: AAF86225.1
DQ138914 Genomic DNA Translation: ABA86520.1
AE013599 Genomic DNA Translation: AAF57514.1
BT125656 mRNA Translation: ADN32842.1

NCBI Reference Sequences

More...RefSeqi		NP_523797.1, NM_079073.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0086336; FBpp0085638; FBgn0034476

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG8595

UCSC genome browser

More...UCSCi		CG8595-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247765 mRNA Translation: AAF86225.1
DQ138914 Genomic DNA Translation: ABA86520.1
AE013599 Genomic DNA Translation: AAF57514.1
BT125656 mRNA Translation: ADN32842.1
RefSeqiNP_523797.1, NM_079073.3

3D structure databases

AlphaFoldDBiQ7KIN0
SMRiQ7KIN0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0085638

PTM databases

SwissPalmiQ7KIN0

Proteomic databases

PaxDbiQ7KIN0

Genome annotation databases

EnsemblMetazoaiFBtr0086336; FBpp0085638; FBgn0034476
GeneIDi37272
KEGGidme:Dmel_CG8595
UCSCiCG8595-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		37272
FlyBaseiFBgn0034476, Toll-7
VEuPathDBiVectorBase:FBgn0034476

Phylogenomic databases

eggNOGiKOG4641, Eukaryota
GeneTreeiENSGT00940000159318
HOGENOMiCLU_004280_0_0_1
InParanoidiQ7KIN0
OMAiEWARCEL
OrthoDBi60380at2759
PhylomeDBiQ7KIN0

Enzyme and pathway databases

ReactomeiR-DME-193634, Axonal growth inhibition (RHOA activation)
R-DME-977606, Regulation of Complement cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37272, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37272

Protein Ontology

More...PROi		PR:Q7KIN0

Gene expression databases

BgeeiFBgn0034476, Expressed in central nervous system and 31 other tissues
ExpressionAtlasiQ7KIN0, baseline and differential

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000157, TIR_dom
IPR035897, Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF00560, LRR_1, 1 hit
PF13855, LRR_8, 6 hits
PF13676, TIR_2, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 20 hits
SM00082, LRRCT, 1 hit
SM00255, TIR, 1 hit
SUPFAMiSSF52200, SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 23 hits
PS50104, TIR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOLL7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KIN0
Secondary accession number(s): E1NZA7, Q2XXU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: October 3, 2006
Last modified: May 25, 2022
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again