Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (18 Sep 2019)
Sequence version 1 (03 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Toll-like receptor 7

Gene

Toll-7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-193634 Axonal growth inhibition (RHOA activation)
R-DME-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 7Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Toll-7Imported
ORF Names:CG8595Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034476 Toll-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 1049ExtracellularCuratedAdd BLAST1033
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1050 – 1070HelicalSequence analysisAdd BLAST21
Topological domaini1071 – 1446CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mistargeting of VA1d ORN axons to a medial position (PubMed:25741726). No effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). RNAi-mediated knockdown results in adults that are acutely sensitive to the vesicular stomatitis virus (vsv) (PubMed:22464169). Following infection with vsv adult survival is decreased, and adults show a dramatic increase in viral RNA production 6 days post vsv infection and viral replication 9 days post infection (PubMed:22464169). Reduced autophagy in adult fat body cells following vsv infection (PubMed:22464169). Starvation-induced autophagy is not affected (PubMed:22464169).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500648979517 – 1446Toll-like receptor 7Add BLAST1430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi722 ↔ 772By similarity
Disulfide bondi796 ↔ 802By similarity
Disulfide bondi800 ↔ 815By similarity
Disulfide bondi966 ↔ 993By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KIN0

PRoteomics IDEntifications database

More...
PRIDEi
Q7KIN0

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7KIN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the fan-shaped body and the ellipsoid body, which are components of the locomotion center in the CNS (at protein level) (PubMed:23892553).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryos, expressed in the ventral neurons, motor neurons and in the longitudinal interneuron axons (at protein level) (PubMed:23892553). May also be expressed in the motor neuron dendrites or possibly the glia (at protein level) (PubMed:23892553). Expressed 48 hours after puparium formation in the lateral glomeruli of the anterior and central regions of the antennal lobe, including the DA1, VA1d and VA1v glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At germ band extension, expressed as 14 stripes in the embryo (PubMed:12617819). At germ band retraction, expressed in a subset of neurons in the CNS, the precursors of the leg imaginal disks and in the ventral epithelium of the large intestine (PubMed:12617819). Expressed in the posterior and anterior spiracles (PubMed:12617819). In stage 16 embryos, expression decreases and is mainly localized to the CNS (PubMed:12617819). Expressed in the proximal region of the wing imaginal disks, around the wing pouch and hinge regions (PubMed:21158756). Also expressed in the distal segments of the leg imaginal disks, with high levels of expression around the A-P border of the tarsal to tibia segments (PubMed:21158756). In larvae, detected in the fat body (PubMed:12617819).5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during vesicular stomatitis virus (VSV) infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034476 Expressed in 24 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085638

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 156LRR 1Sequence analysisAdd BLAST24
Repeati158 – 180LRR 2Sequence analysisAdd BLAST23
Repeati188 – 211LRR 3Sequence analysisAdd BLAST24
Repeati213 – 235LRR 4Sequence analysisAdd BLAST23
Repeati246 – 270LRR 5Sequence analysisAdd BLAST25
Repeati271 – 294LRR 6Sequence analysisAdd BLAST24
Repeati295 – 318LRR 7Sequence analysisAdd BLAST24
Repeati320 – 342LRR 8Sequence analysisAdd BLAST23
Repeati344 – 368LRR 9Sequence analysisAdd BLAST25
Repeati369 – 392LRR 10Sequence analysisAdd BLAST24
Repeati393 – 416LRR 11Sequence analysisAdd BLAST24
Repeati417 – 440LRR 12Sequence analysisAdd BLAST24
Repeati442 – 464LRR 13Sequence analysisAdd BLAST23
Repeati465 – 488LRR 14Sequence analysisAdd BLAST24
Repeati489 – 511LRR 15Sequence analysisAdd BLAST23
Repeati513 – 535LRR 16Sequence analysisAdd BLAST23
Repeati536 – 559LRR 17Sequence analysisAdd BLAST24
Repeati561 – 582LRR 18Sequence analysisAdd BLAST22
Repeati584 – 605LRR 19Sequence analysisAdd BLAST22
Repeati606 – 629LRR 20Sequence analysisAdd BLAST24
Repeati631 – 652LRR 21Sequence analysisAdd BLAST22
Repeati653 – 675LRR 22Sequence analysisAdd BLAST23
Repeati677 – 699LRR 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini716 – 773LRRCTSequence analysisAdd BLAST58
Repeati828 – 851LRR 24Sequence analysisAdd BLAST24
Repeati852 – 875LRR 25Sequence analysisAdd BLAST24
Repeati876 – 899LRR 26Sequence analysisAdd BLAST24
Repeati900 – 923LRR 27Sequence analysisAdd BLAST24
Repeati925 – 947LRR 28Sequence analysisAdd BLAST23
Repeati951 – 979LRR 29Sequence analysisAdd BLAST29
Domaini1096 – 1236TIRPROSITE-ProRule annotationAdd BLAST141

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159318

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7KIN0

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHAFIGR

Database of Orthologous Groups

More...
OrthoDBi
60380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KIN0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 5 hits
PF13676 TIR_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 20 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 23 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7KIN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAILLLLLG FSWSLAVESA LAPKESESSA SAMLGAGTGA AATVSLSGDY
60 70 80 90 100
SSLLSNVPAA SPVPANPSQP SGPANQCSWS YNGTSSVHCA LRLIERQPGL
110 120 130 140 150
DLQGADGSSQ LTIQCSELYL FESTLPVAVF ARLQTLEALR LDSCKLLQLP
160 170 180 190 200
NNAFEGLATL KSLRLSTHNS EWGPTRTLEL FPDSLGGLKQ LTDLDLGDNN
210 220 230 240 250
LRQLPSGFLC PVGNLQVLNL TRNRIRTAEQ MGFADMNCGA GSGSAGSELQ
260 270 280 290 300
VLDASHNELR SISESWGISR LRRLQHLNLA YNNLSELSGE ALAGLASLRI
310 320 330 340 350
VNLSNNHLET LPEGLFAGSK ELREIHLQQN ELYELPKGLF HRLEQLLVVD
360 370 380 390 400
LSGNQLTSNH VDNTTFAGLI RLIVLNLAHN ALTRIDYRTF KELYFLQILN
410 420 430 440 450
LRNNSIGHIE DNAFLPLYNL HTLNLAENRL HTLDDKLFNG LYVLSKLTLN
460 470 480 490 500
NNLISVVEPA VFKNCSDLKE LDLSSNQLNE VPRALQDLAM LRTLDLGENQ
510 520 530 540 550
IRTFDNQSFK NLHQLTGLRL IDNQIGNITV GMFQDLPRLS VLNLAKNRIQ
560 570 580 590 600
SIERGSFDKN FELEAIRLDR NFLADINGVF ATLVSLLWLN LSENHLVWFD
610 620 630 640 650
YAFIPSNLKW LDIHGNYIEA LGNYYKLQEE IRVKTLDASH NRITEIGPMS
660 670 680 690 700
IPNTIELLFI NNNLIGNVQP NAFVDKANLA RVDLYANQLS KLQLQQLRVA
710 720 730 740 750
PVVAPKPLPE FYLGGNPFEC DCTMDWLQRI NNLTTRQHPR VMDMANIECV
760 770 780 790 800
MPHARGAAVR PLSGLRPQDF LCRYESHCFA LCHCCDFDAC DCEMTCPSNC
810 820 830 840 850
TCYHDQIWST NVVDCGGQQT TELPRRVPMD SSVVYLDGNN FPVLKNHAFI
860 870 880 890 900
GRKNLRALYV NGSQVAAIQN RTFASLASLQ LLHLADNKLR TLHGYEFEQL
910 920 930 940 950
SALRELYLQN NQLTTIENAT LAPLAALELI RIDGNRLVTL PIWQMHATHF
960 970 980 990 1000
GTRLKSISLG RNQWSCRCQF LQALTSYVAD NALIVQDAQD IYCMAASSGT
1010 1020 1030 1040 1050
GSAALEDSSS NSGSLEKREL DFNATGAACT DYYSGGSMLQ HGIPESYIPL
1060 1070 1080 1090 1100
LAAALALLFL LVVIAMVFAF RESLRIWLFA HYGVRVFGPR CEESEKLYDA
1110 1120 1130 1140 1150
VLLHSAKDSE FVCQHLAAQL ETGRPPLRVC LQHRDLAHDA THYQLLEATR
1160 1170 1180 1190 1200
VSRRVVILLT RNFLQTEWAR CELRRSVHDA LRGRPQKLVI IEEPEVAFEA
1210 1220 1230 1240 1250
ESDIELLPYL KTSAVHRIRR SDRHFWEKLR YALPVDYPTF RGNNYTLELD
1260 1270 1280 1290 1300
HHNHERVKQP ASPGLLYRQA PPPAYCGPAD AVGIGAVPQV VPVNASVPAE
1310 1320 1330 1340 1350
QNYSTATTAT PSPRPQRRGE QPGSGSGGNH HLHAQYYQHH GMRPPSEHIY
1360 1370 1380 1390 1400
SSIDSDYSTL DNEQHMLMMP GAPGGLAMEA AQRAQTWRPK REQLHLQQAQ
1410 1420 1430 1440
AGTLGSKASQ AAHQQQQQQQ QQQQQQPNPT AVSGQQQGPH VQAYLV
Length:1,446
Mass (Da):160,950
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80D281BDA9500ABC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58P → L in ABA86520 (PubMed:16120803).Curated1
Sequence conflicti124T → K in ABA86520 (PubMed:16120803).Curated1
Sequence conflicti1426Missing in ABA86520 (PubMed:16120803).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF247765 mRNA Translation: AAF86225.1
DQ138914 Genomic DNA Translation: ABA86520.1
AE013599 Genomic DNA Translation: AAF57514.1
BT125656 mRNA Translation: ADN32842.1

NCBI Reference Sequences

More...
RefSeqi
NP_523797.1, NM_079073.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086336; FBpp0085638; FBgn0034476

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8595

UCSC genome browser

More...
UCSCi
CG8595-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247765 mRNA Translation: AAF86225.1
DQ138914 Genomic DNA Translation: ABA86520.1
AE013599 Genomic DNA Translation: AAF57514.1
BT125656 mRNA Translation: ADN32842.1
RefSeqiNP_523797.1, NM_079073.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0085638

PTM databases

SwissPalmiQ7KIN0

Proteomic databases

PaxDbiQ7KIN0
PRIDEiQ7KIN0

Genome annotation databases

EnsemblMetazoaiFBtr0086336; FBpp0085638; FBgn0034476
GeneIDi37272
KEGGidme:Dmel_CG8595
UCSCiCG8595-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37272
FlyBaseiFBgn0034476 Toll-7

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159318
InParanoidiQ7KIN0
OMAiNHAFIGR
OrthoDBi60380at2759
PhylomeDBiQ7KIN0

Enzyme and pathway databases

ReactomeiR-DME-193634 Axonal growth inhibition (RHOA activation)
R-DME-6794361 Neurexins and neuroligins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37272

Protein Ontology

More...
PROi
PR:Q7KIN0

Gene expression databases

BgeeiFBgn0034476 Expressed in 24 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 5 hits
PF13676 TIR_2, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 20 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 23 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOLL7_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KIN0
Secondary accession number(s): E1NZA7, Q2XXU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: October 3, 2006
Last modified: September 18, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again