UniProtKB - Q7K6A5 (Q7K6A5_PLAF7)
Protein
Submitted name:
Multidrug resistance protein 1
Gene
PF3D7_0523000
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 413 – 420 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1161 – 1168 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- response to drug Source: GeneDB
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | HydrolaseImported |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-PFA-159418, Recycling of bile acids and salts R-PFA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-PFA-382556, ABC-family proteins mediated transport R-PFA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_0523000Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0523000 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 82 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 94 – 115 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 316 – 337 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 789 – 810 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 830 – 851 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 904 – 924 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 930 – 948 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1024 – 1048 | HelicalSequence analysisAdd BLAST | 25 |
GO - Cellular componenti
- food vacuole Source: GeneDB
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 345 | ABC transmembrane type-1InterPro annotationAdd BLAST | 288 | |
Domaini | 378 – 662 | ABC transporterInterPro annotationAdd BLAST | 285 | |
Domaini | 791 – 1083 | ABC transmembrane type-1InterPro annotationAdd BLAST | 293 | |
Domaini | 1126 – 1416 | ABC transporterInterPro annotationAdd BLAST | 291 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 639 – 665 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 697 – 752 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 697 – 747 | PolarSequence analysisAdd BLAST | 51 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | Q7K6A5 |
OMAi | LFMLPMT |
PhylomeDBi | Q7K6A5 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 3 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q7K6A5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP
60 70 80 90 100
AQHRKLLFIS FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS
110 120 130 140 150
IGLVQFILSM ISSYCMDVIT SKILKTLKLE YLRSVFYQDG QFHDNNPGSK
160 170 180 190 200
LRSDLDFYLE QVSSGIGTKF ITIFTYASSF LGLYIWSLIK NARLTLCITC
210 220 230 240 250
VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG IRTVASYCGE
260 270 280 290 300
KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI
310 320 330 340 350
IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT
360 370 380 390 400
NSLYEIINRK PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS
410 420 430 440 450
FTLKEGKTYA FVGESGCGKS TILKLIERLY DPTEGDIIVN DSHNLKDINL
460 470 480 490 500
KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY SLKDLEAMEN YYEENTNDTY
510 520 530 540 550
ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL IHDFVSSLPD
560 570 580 590 600
KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL
610 620 630 640 650
VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND
660 670 680 690 700
DNNNNNNNNN NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK
710 720 730 740 750
SSNNGNDNGS DNKSSAYKDS DTGNDADNMN SLSIHENENI SNNRNCKNTA
760 770 780 790 800
ENEKEEKVPF FKRMFRRKKK APNNLRIIYK EIFSYKKDVT IIFFSILVAG
810 820 830 840 850
GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA MFISETLKNY
860 870 880 890 900
YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL
910 920 930 940 950
KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR
960 970 980 990 1000
ARLTKSKEIE KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG
1010 1020 1030 1040 1050
LEDYFCNLIE KAIDYKNKGQ KRRIIVNAAL WGFSQSAQLF INSFAYWFGS
1060 1070 1080 1090 1100
FLIKRGTILV DDFMKSLFTF IFTGSYAGKL MSLKGDSENA KLSFEKYYPL
1110 1120 1130 1140 1150
MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN VPIYKNLSFT
1160 1170 1180 1190 1200
CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN
1210 1220 1230 1240 1250
NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL
1260 1270 1280 1290 1300
FSIVSQEPML FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK
1310 1320 1330 1340 1350
YDTNVGPYGK SLSGGQKQRI AIARALLREP KILLLDEATS SLDSNSEKLI
1360 1370 1380 1390 1400
EKTIVDIKDK ADKTIITIAH RIASIKRSDK IVVFNNPDRN GTFVQSHGTH
1410
DELLSAQDGI YKKYVKLAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844504 Genomic DNA Translation: CAD51594.1 |
RefSeqi | XP_001351787.1, XM_001351751.1 |
Genome annotation databases
EnsemblProtistsi | CAD51594; CAD51594; PF3D7_0523000 |
GeneDBi | PF3D7_0523000.1:pep |
GeneIDi | 813045 |
KEGGi | pfa:PF3D7_0523000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844504 Genomic DNA Translation: CAD51594.1 |
RefSeqi | XP_001351787.1, XM_001351751.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | Q7K6A5 |
Proteomic databases
PRIDEi | Q7K6A5 |
Genome annotation databases
EnsemblProtistsi | CAD51594; CAD51594; PF3D7_0523000 |
GeneDBi | PF3D7_0523000.1:pep |
GeneIDi | 813045 |
KEGGi | pfa:PF3D7_0523000 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0523000 |
Phylogenomic databases
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | Q7K6A5 |
OMAi | LFMLPMT |
PhylomeDBi | Q7K6A5 |
Enzyme and pathway databases
Reactomei | R-PFA-159418, Recycling of bile acids and salts R-PFA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-PFA-382556, ABC-family proteins mediated transport R-PFA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 3 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7K6A5_PLAF7 | |
Accessioni | Q7K6A5Primary (citable) accession number: Q7K6A5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |