UniProtKB - Q7K5K3 (Q7K5K3_DROME)
Protein
Pyruvate dehydrogenase E1 component subunit beta
Gene
Pdhb
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation
Catalytic activityi
- [dihydrolipoyllysine-residue acetyltransferase]-(R)-N6-lipoyl-L-lysine + H+ + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N6-(S8-acetyldihydrolipoyl)-L-lysine + CO2UniRule annotationARBA annotationEC:1.2.4.1UniRule annotationARBA annotation
Cofactori
thiamine diphosphateUniRule annotationARBA annotation
GO - Molecular functioni
- pyruvate dehydrogenase (acetyl-transferring) activity Source: FlyBase
GO - Biological processi
- acetyl-CoA biosynthetic process from pyruvate Source: GO_Central
- pyruvate metabolic process Source: FlyBase
Keywordsi
Molecular function | OxidoreductaseUniRule annotationImported |
Ligand | PyruvateUniRule annotationImportedARBA annotation, Thiamine pyrophosphateUniRule annotation |
Enzyme and pathway databases
Reactomei | R-DME-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-DME-389661, Glyoxylate metabolism and glycine degradation R-DME-5362517, Signaling by Retinoic Acid R-DME-70268, Pyruvate metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Pyruvate dehydrogenase E1 component subunit betaUniRule annotation (EC:1.2.4.1UniRule annotation) |
Gene namesi | Name:PdhbImported Synonyms:CG 11876Imported, Dmel\CG11876Imported, dPDHBImported, E1betaImported, PdhImported, PDHBImported, PDHbetaImported ORF Names:CG11876Imported, Dmel_CG11876Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0039635, Pdhb |
Subcellular locationi
Mitochondrion
- mitochondrial pyruvate dehydrogenase complex Source: GO_Central
- mitochondrion Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0039635, Expressed in second segment of antenna (Drosophila) and 54 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q7K5K3, 9 interactors |
STRINGi | 7227.FBpp0084735 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 204 | Transket_pyrInterPro annotationAdd BLAST | 176 |
Phylogenomic databases
eggNOGi | KOG0524, Eukaryota |
GeneTreei | ENSGT00940000155146 |
HOGENOMi | CLU_012907_1_1_1 |
OMAi | SRMRHHC |
OrthoDBi | 875272at2759 |
Family and domain databases
Gene3Di | 3.40.50.920, 1 hit |
InterProi | View protein in InterPro IPR027110, PDHB IPR029061, THDP-binding IPR009014, Transketo_C/PFOR_II IPR005475, Transketolase-like_Pyr-bd IPR033248, Transketolase_C |
PANTHERi | PTHR11624, PTHR11624, 1 hit |
Pfami | View protein in Pfam PF02779, Transket_pyr, 1 hit PF02780, Transketolase_C, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit SSF52922, SSF52922, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7K5K3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRTRLIQAA SSAQRAFSTS QKALAAKQMT VRDALNSALD DELARDDRVF
60 70 80 90 100
ILGEEVAQYD GAYKVSRGLW KKYGDKRVID TPITEMGFAG IAVGAAMAGL
110 120 130 140 150
RPVCEFMTWN FSMQAIDHII NSAAKTFYMS AGAVNVPIVF RGPNGAASGV
160 170 180 190 200
AAQHSQCFAA WYAHCPGLKV LSPYDAEDAR GLLKSAIRDP DPVVFLENEL
210 220 230 240 250
VYGTAFPVAD NVADKDFLVP IGKAKVMRPG KDITLVAHSK AVETSLLAAA
260 270 280 290 300
ELAKKGIEAE VINLRSIRPL DTATIFASVR KTHHLVTVEN GWPQHGVGAE
310 320 330 340 350
ICARIMEDQT FFELDAPVWR CAGVDVPMPY AKTLEAHALP RVQDLVEATL
360
KVLGGKVGKA AAANK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8IML6 | Q8IML6_DROME | Pyruvate dehydrogenase E1 component... | Pdhb CG 11876, Dmel\CG11876, dPDHB, E1beta, Pdh | 273 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56855.2 AY047573 mRNA Translation: AAK77305.1 AE014297 Genomic DNA Translation: AAN14149.1 |
RefSeqi | NP_651668.1, NM_143411.4 NP_733265.1, NM_170386.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0085366; FBpp0084735; FBgn0039635 FBtr0085369; FBpp0084738; FBgn0039635 |
GeneIDi | 43437 |
KEGGi | dme:Dmel_CG11876 |
UCSCi | CG11876-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF56855.2 AY047573 mRNA Translation: AAK77305.1 AE014297 Genomic DNA Translation: AAN14149.1 |
RefSeqi | NP_651668.1, NM_143411.4 NP_733265.1, NM_170386.2 |
3D structure databases
SMRi | Q7K5K3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q7K5K3, 9 interactors |
STRINGi | 7227.FBpp0084735 |
Proteomic databases
PRIDEi | Q7K5K3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085366; FBpp0084735; FBgn0039635 FBtr0085369; FBpp0084738; FBgn0039635 |
GeneIDi | 43437 |
KEGGi | dme:Dmel_CG11876 |
UCSCi | CG11876-RA, d. melanogaster |
Organism-specific databases
CTDi | 5162 |
FlyBasei | FBgn0039635, Pdhb |
Phylogenomic databases
eggNOGi | KOG0524, Eukaryota |
GeneTreei | ENSGT00940000155146 |
HOGENOMi | CLU_012907_1_1_1 |
OMAi | SRMRHHC |
OrthoDBi | 875272at2759 |
Enzyme and pathway databases
Reactomei | R-DME-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-DME-389661, Glyoxylate metabolism and glycine degradation R-DME-5362517, Signaling by Retinoic Acid R-DME-70268, Pyruvate metabolism |
Miscellaneous databases
BioGRID-ORCSi | 43437, 2 hits in 3 CRISPR screens |
ChiTaRSi | Pdh, fly |
GenomeRNAii | 43437 |
Gene expression databases
Bgeei | FBgn0039635, Expressed in second segment of antenna (Drosophila) and 54 other tissues |
Family and domain databases
Gene3Di | 3.40.50.920, 1 hit |
InterProi | View protein in InterPro IPR027110, PDHB IPR029061, THDP-binding IPR009014, Transketo_C/PFOR_II IPR005475, Transketolase-like_Pyr-bd IPR033248, Transketolase_C |
PANTHERi | PTHR11624, PTHR11624, 1 hit |
Pfami | View protein in Pfam PF02779, Transket_pyr, 1 hit PF02780, Transketolase_C, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 1 hit SSF52922, SSF52922, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7K5K3_DROME | |
Accessioni | Q7K5K3Primary (citable) accession number: Q7K5K3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |