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Entry version 114 (12 Aug 2020)
Sequence version 1 (03 Oct 2006)
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Protein

7SK snRNA methylphosphate capping enzyme bin3

Gene

bin3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (By similarity). Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex (PubMed:21262214).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei808S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei1010S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • methyltransferase activity Source: FlyBase
  • O-methyltransferase activity Source: GO_Central
  • RNA methyltransferase activity Source: GO_Central
  • RNA polymerase II transcription factor binding Source: FlyBase
  • snRNA binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
7SK snRNA methylphosphate capping enzyme bin3Curated (EC:2.1.1.-By similarity)
Alternative name(s):
Bicoid-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bin3
ORF Names:CG8276
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263144, bin3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe defect in oogenesis: females lay eggs, however, up to 50% do not initiate development and many show a dorsalized phenotype. Among the eggs that do initiate development, up to 20% fail to complete embryogenesis and of these, nearly all display severe head defects and die as unhatched larvae or die soon after hatching. Mutants show anterior pattern defects and fail to repress the translation of caudal mRNA and exhibit head involution defects. Mutants also display a severe reduction in the level of 7SK RNA and reduced binding of bicoid/bcd to the caudal 3' UTR.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002892691 – 13677SK snRNA methylphosphate capping enzyme bin3Add BLAST1367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei688Phosphoserine1 Publication1
Modified residuei1116Phosphothreonine1 Publication1
Modified residuei1123Phosphoserine1 Publication1
Modified residuei1242Phosphoserine1 Publication1
Modified residuei1251Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7K480

PRoteomics IDEntifications database

More...
PRIDEi
Q7K480

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7K480

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Distributed throughout the early embryo.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detectable in early embryos. Present coincident with bicoid/bcd expression, with peak levels detected in 0-2 hours embryos. Expression is lower during cellularization stages (2-4 hours) and drops dramatically during late embryonic development (4-24 hours). Very little, if any expression is detected in unfertilized eggs.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263144, Expressed in cleaving embryo and 51 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7K480, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7K480, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with bicoid/bcd.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61453, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q7K480, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085336

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini806 – 1115Bin3-type SAMPROSITE-ProRule annotationAdd BLAST310

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni828 – 830S-adenosyl-L-methionine bindingBy similarity3
Regioni851 – 852S-adenosyl-L-methionine bindingBy similarity2
Regioni988 – 989S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 253Gly-richAdd BLAST109
Compositional biasi150 – 211His-richAdd BLAST62
Compositional biasi915 – 926His-richAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2899, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153993

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_247680_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7K480

KEGG Orthology (KO)

More...
KOi
K15190

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAGNNAN

Database of Orthologous Groups

More...
OrthoDBi
1185441at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7K480

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039772, Bin3-like
IPR010675, Bin3_C
IPR024160, BIN3_SAM-bd_dom
IPR025714, Methyltranfer_dom
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR12315, PTHR12315, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06859, Bin3, 1 hit
PF13847, Methyltransf_31, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51515, BIN3_SAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7K480-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKRLSDSPG DCRVTRSTMT PTLRLDQTSR QEPLPQQPDN GPAAAPGKSK
60 70 80 90 100
SPTPLPGKSQ AAQHHQFRAP QQQQGPKNRN KAWSKRQHKA GGKHNPSACV
110 120 130 140 150
GASSGQAQST GSSVIAATLL PTAASAHKAD LENIQNIHNK NLTAGGGVNH
160 170 180 190 200
HGNAGTAHHG GGGGAGAHHA AAGGHHHHHN TRLAQNAAAG GASGGGTIQM
210 220 230 240 250
HKKMLRGHHH HVLCAGNNAN HTCCLVTGCN GSSIGGVGVA GSGGATASAG
260 270 280 290 300
GGGASCKEAQ SCKDTSSLSG NSSIAGSAGA GNAVHYCCGR SKFFLPEKRL
310 320 330 340 350
RKEVIVPPTK FLLGGNISDP LNLNSLQNEN TSNASSTNNT PATTPRQSPI
360 370 380 390 400
TTPPKVEVII PPNIHDPLHL LDPVDSMEYE KQLTSPMKRA GPGGGMLHHR
410 420 430 440 450
QHHYRTRKNR KRRRFDSNNT SHAGDEGGVG SELTDEPPLP AATSSLAASP
460 470 480 490 500
VAAPLNVGGS LLLSESAAPA PGETAEMGQQ QEQAHVHSPQ SASTTTTAAE
510 520 530 540 550
MPTPTPTSAA AATATAEHKE QSAPAPTATS SPQRQQQHVA AAAEELPTPE
560 570 580 590 600
TSAAAETPAE EMLLSCSATS ASLVASTLAE RRASRDLRLD LSSTCYGVGG
610 620 630 640 650
TGLSFGGSIS SSVGSSFGGG GRKRKISESS TSQKSKKFHR HDAMDKIVSP
660 670 680 690 700
VVPQPGAWKR PPRILQPSGA RKPSTRRSTS VSESELLSPV EEQPPKQLPL
710 720 730 740 750
IGVEIPRDDT PDLPDHGLGS PLSTTSGATS HTAGEQDSLA GVDISMGDTL
760 770 780 790 800
GSGVVGKAPL TSSLMLEPAK IPPIKMLPKF RADGLKYRYG NFDRYVDFRQ
810 820 830 840 850
MNEFRDVRLQ VFQRHVELFE NKDILDIGCN VGHMTITVAR HLAPKTIVGI
860 870 880 890 900
DIDRELVARA RRNLSIFVRI PKEEKLLEVK AEPTVDAKAN IAVKDETSGA
910 920 930 940 950
AHKKTRRGKR RRKVHQGIHH HHHHHHDLEQ LQQQQKLNSL LVKPHEFFPI
960 970 980 990 1000
SFPLTYGRIP RILSSSKSPN MLGNKNQFPA NVFFRHTNYV LKDESLMASD
1010 1020 1030 1040 1050
TQQYDLILCL SVTKWIHLNF GDNGLKMAFK RMFNQLRPGG KLILEAQNWA
1060 1070 1080 1090 1100
SYKKKKNLTP EIYNNYKQIE FFPNKFHEYL LSSEVGFSHS YTLGVPRHMN
1110 1120 1130 1140 1150
KGFCRPIQLY AKGDYTPNHV RWSDAYYPQT PYEAYRGIYA TLPVHRMGGG
1160 1170 1180 1190 1200
GSSAGGSNSG HAQMLHLSSS SRSQNYDTPH YAGSASGSAS CRQTPMYQPT
1210 1220 1230 1240 1250
YNPLETDSYQ PSYDMEYLNH MYVFASPLYQ TVWSPPASLR KSSSHTPVFG
1260 1270 1280 1290 1300
SVRDAELDGD GSGGGGSGGG SYHRHVYPPN DDTCSPNANA CNAFNSIRDA
1310 1320 1330 1340 1350
DTDDSNQLPG GSRRHVYATN CGESSSSPQV NHHDAVGEFV DGLMDDEQKS
1360
STGGGTGGAA YCDLSDA
Length:1,367
Mass (Da):146,234
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA3EDD8FDAA7A551
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QC61E2QC61_DROME
Bicoid-interacting protein 3, isofo...
bin3 Bin3, Dmel\CG8276, l(2)SH1014, l(2)SH2 1014, CG8276
1,367Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO47868 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti573L → LA in AAF63187 (PubMed:10717484).Curated1
Sequence conflicti1152S → G in AAO47868 (Ref. 5) Curated1
Sequence conflicti1267S → R in AAO47868 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF097636 mRNA Translation: AAF63187.1
AE013599 Genomic DNA Translation: AAF57267.2
AY052142 mRNA Translation: AAK93566.1
BT004890 mRNA Translation: AAO47868.1 Frameshift.

NCBI Reference Sequences

More...
RefSeqi
NP_001260724.1, NM_001273795.1
NP_001303336.1, NM_001316407.1
NP_523626.2, NM_078902.3
NP_724468.1, NM_165468.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085992; FBpp0085336; FBgn0263144
FBtr0085993; FBpp0085337; FBgn0263144
FBtr0336519; FBpp0307591; FBgn0263144
FBtr0346718; FBpp0312329; FBgn0263144

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8276

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097636 mRNA Translation: AAF63187.1
AE013599 Genomic DNA Translation: AAF57267.2
AY052142 mRNA Translation: AAK93566.1
BT004890 mRNA Translation: AAO47868.1 Frameshift.
RefSeqiNP_001260724.1, NM_001273795.1
NP_001303336.1, NM_001316407.1
NP_523626.2, NM_078902.3
NP_724468.1, NM_165468.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi61453, 7 interactors
IntActiQ7K480, 8 interactors
STRINGi7227.FBpp0085336

PTM databases

iPTMnetiQ7K480

Proteomic databases

PaxDbiQ7K480
PRIDEiQ7K480

Genome annotation databases

EnsemblMetazoaiFBtr0085992; FBpp0085336; FBgn0263144
FBtr0085993; FBpp0085337; FBgn0263144
FBtr0336519; FBpp0307591; FBgn0263144
FBtr0346718; FBpp0312329; FBgn0263144
GeneIDi35552
KEGGidme:Dmel_CG8276

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55909
FlyBaseiFBgn0263144, bin3

Phylogenomic databases

eggNOGiKOG2899, Eukaryota
GeneTreeiENSGT00940000153993
HOGENOMiCLU_247680_0_0_1
InParanoidiQ7K480
KOiK15190
OMAiCAGNNAN
OrthoDBi1185441at2759
PhylomeDBiQ7K480

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
35552, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
35552

Protein Ontology

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PROi
PR:Q7K480

Gene expression databases

BgeeiFBgn0263144, Expressed in cleaving embryo and 51 other tissues
ExpressionAtlasiQ7K480, baseline and differential
GenevisibleiQ7K480, DM

Family and domain databases

InterProiView protein in InterPro
IPR039772, Bin3-like
IPR010675, Bin3_C
IPR024160, BIN3_SAM-bd_dom
IPR025714, Methyltranfer_dom
IPR029063, SAM-dependent_MTases
PANTHERiPTHR12315, PTHR12315, 1 hit
PfamiView protein in Pfam
PF06859, Bin3, 1 hit
PF13847, Methyltransf_31, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51515, BIN3_SAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEPCE_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7K480
Secondary accession number(s): Q86LF5, Q9NJV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 3, 2006
Last modified: August 12, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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