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UniProtKB - Q7K3T4 (Q7K3T4_DROME)
Protein
Palmitoyltransferase
Gene
anon-WO0118547.93
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]UniRule annotationEC:2.3.1.225UniRule annotation
GO - Molecular functioni
- protein-cysteine S-palmitoyltransferase activity Source: FlyBase
GO - Biological processi
- peptidyl-L-cysteine S-palmitoylation Source: GO_Central
- protein palmitoylation Source: FlyBase
- protein targeting to membrane Source: GO_Central
Keywordsi
Molecular function | AcyltransferaseUniRule annotationImported, Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:anon-WO0118547.93Imported Synonyms:Dmel\CG8314Imported ORF Names:CG8314Imported, Dmel_CG8314Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034057, CG8314 |
VEuPathDBi | VectorBase:FBgn0034057 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: FlyBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 60 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 66 – 86 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 165 – 188 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 208 – 230 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneInteractioni
Protein-protein interaction databases
IntActi | Q7K3T4, 4 interactors |
STRINGi | 7227.FBpp0086406 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 122 – 248 | DHHCInterPro annotationAdd BLAST | 127 |
Domaini
The DHHC domain is required for palmitoyltransferase activity.UniRule annotation
Sequence similaritiesi
Belongs to the DHHC palmitoyltransferase family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000155721 |
HOGENOMi | CLU_048061_1_0_1 |
OMAi | CVVMTWL |
OrthoDBi | 1491968at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7K3T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNYSYSALSP GGSGGFGGVD QHNRCCGNKA WCVKDICGIV CVIMTWLLIL
60 70 80 90 100
FAEFVVMRLI LLPSNYTVFS TINMIIFQAL AFLAFASHIR TMLSDPGAVP
110 120 130 140 150
RGNATKEMIE QMGYREGQMF YKCPKCCSIK PERAHHCSVC QRCIRKMDHH
160 170 180 190 200
CPWVNNCVGE NNQKYFVLFT FYIASISVHT LFLVLTQFAE CVKNDWRTCS
210 220 230 240 250
PYSPPATIFL LLFLTFEGLM FGIFTIIMLA TQLTAILNDQ TGIEQLKKEE
260 270 280 290
ARWAKKSRLK SIQSVFGRFS LAWFSPFTEP SCRTRFNSHF YSV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58085.1 AY058364 mRNA Translation: AAL13593.1 |
RefSeqi | NP_611070.1, NM_137226.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0087268; FBpp0086406; FBgn0034057 |
GeneIDi | 36757 |
KEGGi | dme:Dmel_CG8314 |
UCSCi | CG8314-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58085.1 AY058364 mRNA Translation: AAL13593.1 |
RefSeqi | NP_611070.1, NM_137226.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q7K3T4, 4 interactors |
STRINGi | 7227.FBpp0086406 |
Genome annotation databases
EnsemblMetazoai | FBtr0087268; FBpp0086406; FBgn0034057 |
GeneIDi | 36757 |
KEGGi | dme:Dmel_CG8314 |
UCSCi | CG8314-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0034057, CG8314 |
VEuPathDBi | VectorBase:FBgn0034057 |
Phylogenomic databases
eggNOGi | KOG1311, Eukaryota |
GeneTreei | ENSGT00940000155721 |
HOGENOMi | CLU_048061_1_0_1 |
OMAi | CVVMTWL |
OrthoDBi | 1491968at2759 |
Miscellaneous databases
BioGRID-ORCSi | 36757, 0 hits in 3 CRISPR screens |
GenomeRNAii | 36757 |
Gene expression databases
Bgeei | FBgn0034057, Expressed in larva and 39 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7K3T4_DROME | |
Accessioni | Q7K3T4Primary (citable) accession number: Q7K3T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | January 19, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |