Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 118 (11 Dec 2019)
Sequence version 1 (03 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Guanylate kinase-associated protein mars

Gene

mars

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell cycle regulator.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: FlyBase
  • protein phosphatase 1 binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylate kinase-associated protein mars
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mars
Synonyms:gkap
ORF Names:CG17064
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033845 mars

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728411 – 921Guanylate kinase-associated protein marsAdd BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49Phosphoserine1 Publication1
Modified residuei51Phosphothreonine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei170Phosphoserine1 Publication1
Modified residuei172Phosphotyrosine1 Publication1
Modified residuei444Phosphoserine1 Publication1
Modified residuei519Phosphothreonine1 Publication1
Modified residuei554Phosphoserine2 Publications1
Modified residuei785Phosphoserine1 Publication1
Modified residuei792Phosphoserine1 Publication1
Modified residuei826Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7K3L1

PRoteomics IDEntifications database

More...
PRIDEi
Q7K3L1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7K3L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the central nervous system and at different stages of gametogenesis. In embryos, it is expressed in central nervous system and brain. In testis, it is strongly expressed in pre-meiotic germ cells, but is not found in somatic or post-meiotic cells.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in embryos and in the adult germline (at protein level). Only present in mitotic cells; at the anaphase and telophase, its begins to degrade.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033845 Expressed in 59 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7K3L1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7K3L1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62257, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q7K3L1, 21 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290601

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7K3L1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3971 Eukaryota
ENOG4111JKV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158652

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7K3L1

KEGG Orthology (KO)

More...
KOi
K16804

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRQNRGV

Database of Orthologous Groups

More...
OrthoDBi
1473267at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7K3L1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005026 SAPAP

The PANTHER Classification System

More...
PANTHERi
PTHR12353 PTHR12353, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03359 GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7K3L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRHKELYKE QSLVLSPRNH CQENRDRLQA ARAKKREDCF YQNRIISVSP
60 70 80 90 100
TPVKIKQLAA AQAALTQENV APKLESPERL DTKPAELLKE SNPKVSRQKL
110 120 130 140 150
YLQRYMEWKI AKTKEHKQQD QKRRGAAINV PTVKQSKALP KSQTFRVPDN
160 170 180 190 200
LASAKQKEAA PMFQPPKRCS LYMIANPTGK GKAAEPIKPS IPKPTSAAAP
210 220 230 240 250
PSSNTVAASS ALARHKSAAS ATKIVPAIRQ NNNPVALARQ KAAARPIPNT
260 270 280 290 300
TKQTTSVRQP GIEAKKITTT IPRPTPATVT KAKTPGIRQQ PPVVSTKPRL
310 320 330 340 350
PEPPAPRTAR LPNVLSKPFE KPLGNKAPVT RRANVVKPQP IRGGGGAAAK
360 370 380 390 400
FKDTAGATSK AASHSIRMKA TKIKSQYTRL QDNVRKLPQL KAELLHAATL
410 420 430 440 450
DIPPLTPLDD IHNPFIDQAT STQCKSNNSS GHLLEAFGDT ILLSPVAPVK
460 470 480 490 500
AEGESSVKRQ LLPEGKKEAS GPVAKKKFDF TRYSVANSPA EDSLILDPQQ
510 520 530 540 550
TTVKEDTGDS TLVPEGTKTP PRRESNGMPN YLSPFVSVSR GKVNSRCEKE
560 570 580 590 600
KRNSFYLSNE ESPLEVRRAI ESVLYFRLQL ENEITRLQAL CAEWEAYSKE
610 620 630 640 650
NEARLQETGG IDMINVTIGQ TRLLTTKKMM QFSGLIDRCE AGATGKNSQP
660 670 680 690 700
NDGSEDSKPV QAEDLEGWWD MLRLQSENVD KRFDNLKRWK ANDWLDPDAV
710 720 730 740 750
AEEPKQPKPK PKISRNMKIK SKAKPSSNLQ QFLRKAHANM KKTKVEEPTL
760 770 780 790 800
EDGLPATSSR HSSPRVIVVR NRRSFSPART VLRMSTGEGR QSIAPNALLK
810 820 830 840 850
SAILAAAEQN AAKTPPPKPR TSILKTPGTT KRQNRGVLFS AKKSVRRFQF
860 870 880 890 900
TYEEGNISND ETVGADKLED CEEDMSLEAS TESGSLEQNP GRDSNQENEA
910 920
TPRTYTLRNR RVNLRPSSEF M
Length:921
Mass (Da):101,946
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0139CBDF715F5346
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JH57E1JH57_DROME
Mars, isoform B
mars D-HURP, dhrp, Dmel\CG17064, gkap, HURP
921Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ565928 mRNA Translation: CAD92805.1
AE013599 Genomic DNA Translation: AAF58367.1
AY058511 mRNA Translation: AAL13740.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163142.1, NM_001169671.2
NP_001286387.1, NM_001299458.1
NP_001286388.1, NM_001299459.1
NP_610878.1, NM_137034.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087668; FBpp0086788; FBgn0033845
FBtr0301387; FBpp0290601; FBgn0033845
FBtr0344895; FBpp0311206; FBgn0033845
FBtr0344896; FBpp0311207; FBgn0033845

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17064

UCSC genome browser

More...
UCSCi
CG17064-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ565928 mRNA Translation: CAD92805.1
AE013599 Genomic DNA Translation: AAF58367.1
AY058511 mRNA Translation: AAL13740.1
RefSeqiNP_001163142.1, NM_001169671.2
NP_001286387.1, NM_001299458.1
NP_001286388.1, NM_001299459.1
NP_610878.1, NM_137034.4

3D structure databases

SMRiQ7K3L1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi62257, 18 interactors
IntActiQ7K3L1, 21 interactors
STRINGi7227.FBpp0290601

PTM databases

iPTMnetiQ7K3L1

Proteomic databases

PaxDbiQ7K3L1
PRIDEiQ7K3L1

Genome annotation databases

EnsemblMetazoaiFBtr0087668; FBpp0086788; FBgn0033845
FBtr0301387; FBpp0290601; FBgn0033845
FBtr0344895; FBpp0311206; FBgn0033845
FBtr0344896; FBpp0311207; FBgn0033845
GeneIDi36498
KEGGidme:Dmel_CG17064
UCSCiCG17064-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
216443
FlyBaseiFBgn0033845 mars

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00940000158652
InParanoidiQ7K3L1
KOiK16804
OMAiKRQNRGV
OrthoDBi1473267at2759
PhylomeDBiQ7K3L1

Enzyme and pathway databases

ReactomeiR-DME-6794361 Neurexins and neuroligins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36498

Protein Ontology

More...
PROi
PR:Q7K3L1

Gene expression databases

BgeeiFBgn0033845 Expressed in 59 organ(s), highest expression level in embryo
ExpressionAtlasiQ7K3L1 baseline and differential
GenevisibleiQ7K3L1 DM

Family and domain databases

InterProiView protein in InterPro
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARS_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7K3L1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 3, 2006
Last modified: December 11, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again