UniProtKB - Q7K2D2 (DCTN2_DROME)
Protein
Dynactin subunit 2
Gene
DCTN2-p50
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity).By similarity
GO - Molecular functioni
- motor activity Source: UniProtKB-KW
GO - Biological processi
- centrosome localization Source: FlyBase
- clathrin-dependent endocytosis involved in vitellogenesis Source: FlyBase
- mitotic metaphase plate congression Source: UniProtKB
- mitotic spindle organization Source: UniProtKB
- mRNA transport Source: FlyBase
- oocyte microtubule cytoskeleton organization Source: FlyBase
- oogenesis Source: FlyBase
- phototransduction Source: FlyBase
- pole plasm oskar mRNA localization Source: FlyBase
- positive regulation of retrograde axon cargo transport Source: FlyBase
- retrograde axonal transport Source: FlyBase
- spindle organization Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Dynactin subunit 2Short name: Dynamitin Alternative name(s): Dynactin 2 p50 subunitImported |
Gene namesi | ORF Names:CG8269Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0021825, DCTN2-p50 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- centrosome Source: GO_Central
- dynactin complex Source: UniProtKB
- dynein complex Source: UniProtKB-KW
- microtubule Source: UniProtKB-KW
Other locations
- axon cytoplasm Source: GOC
- cell cortex Source: FlyBase
- cytoplasm Source: GO_Central
- membrane Source: UniProtKB-SubCell
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Dynein, Membrane, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288772 | 1 – 380 | Dynactin subunit 2Add BLAST | 380 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | Phosphoserine1 Publication | 1 | |
Modified residuei | 58 | Phosphoserine1 Publication | 1 | |
Modified residuei | 86 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q7K2D2 |
PRIDEi | Q7K2D2 |
PTM databases
iPTMneti | Q7K2D2 |
Expressioni
Gene expression databases
Bgeei | FBgn0021825, Expressed in oviduct (Drosophila) and 47 other tissues |
Genevisiblei | Q7K2D2, DM |
Interactioni
Subunit structurei
Subunit of dynactin, a multiprotein complex associated with dynein.
By similarityProtein-protein interaction databases
BioGRIDi | 68822, 34 interactors |
IntActi | Q7K2D2, 2 interactors |
STRINGi | 7227.FBpp0087722 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 100 – 135 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 353 – 377 | Sequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the dynactin subunit 2 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3958, Eukaryota |
GeneTreei | ENSGT00390000003427 |
HOGENOMi | CLU_049964_1_0_1 |
InParanoidi | Q7K2D2 |
OMAi | HSVQETF |
OrthoDBi | 951183at2759 |
PhylomeDBi | Q7K2D2 |
Family and domain databases
InterProi | View protein in InterPro IPR028133, Dynamitin |
PANTHERi | PTHR15346, PTHR15346, 1 hit |
Pfami | View protein in Pfam PF04912, Dynamitin, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7K2D2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADPKFQNLP GIAYDQPDVY ETPDDPELDT SDYYEEEPEN EAIERLHISP
60 70 80 90 100
SVAHKRFSGA TVEGSVDFTD RIGRRMCRGY DTRGSSDYEL VGQGEKETPV
110 120 130 140 150
QKCQRLQIEM NELLNEVAAL QVDRKVADEE KQSYDAVATV ISTARKVLES
160 170 180 190 200
LKLEQVLGKE QTPGSKQVKA LISQVEEFKQ SGVLTAIPTP GTDLAATARV
210 220 230 240 250
ASLEQRISQL EKVLGAQPDK LSRLTAATNT TNVLEAVRHL STKAALIQPD
260 270 280 290 300
KLDTIEQRLT SLAGKMDAIA EKSSGSAQDA KRDQKITELY DIAKRTEPVV
310 320 330 340 350
EILPHVIERM QALEALHKYA NNFAKIIAEI EQKQGTITTS LVNNKELLHS
360 370 380
VQETFAQNLE TINSKVAKVE QRVAAISSAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59034.1 AY061092 mRNA Translation: AAL28640.1 |
RefSeqi | NP_524690.1, NM_079951.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0088641; FBpp0087722; FBgn0021825 |
GeneIDi | 44086 |
KEGGi | dme:Dmel_CG8269 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF59034.1 AY061092 mRNA Translation: AAL28640.1 |
RefSeqi | NP_524690.1, NM_079951.3 |
3D structure databases
SMRi | Q7K2D2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68822, 34 interactors |
IntActi | Q7K2D2, 2 interactors |
STRINGi | 7227.FBpp0087722 |
PTM databases
iPTMneti | Q7K2D2 |
Proteomic databases
PaxDbi | Q7K2D2 |
PRIDEi | Q7K2D2 |
Genome annotation databases
EnsemblMetazoai | FBtr0088641; FBpp0087722; FBgn0021825 |
GeneIDi | 44086 |
KEGGi | dme:Dmel_CG8269 |
Organism-specific databases
CTDi | 44086 |
FlyBasei | FBgn0021825, DCTN2-p50 |
Phylogenomic databases
eggNOGi | KOG3958, Eukaryota |
GeneTreei | ENSGT00390000003427 |
HOGENOMi | CLU_049964_1_0_1 |
InParanoidi | Q7K2D2 |
OMAi | HSVQETF |
OrthoDBi | 951183at2759 |
PhylomeDBi | Q7K2D2 |
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 44086, 0 hits in 1 CRISPR screen |
GenomeRNAii | 44086 |
PROi | PR:Q7K2D2 |
Gene expression databases
Bgeei | FBgn0021825, Expressed in oviduct (Drosophila) and 47 other tissues |
Genevisiblei | Q7K2D2, DM |
Family and domain databases
InterProi | View protein in InterPro IPR028133, Dynamitin |
PANTHERi | PTHR15346, PTHR15346, 1 hit |
Pfami | View protein in Pfam PF04912, Dynamitin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCTN2_DROME | |
Accessioni | Q7K2D2Primary (citable) accession number: Q7K2D2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families