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Entry version 148 (19 Jan 2022)
Sequence version 1 (03 Oct 2006)
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Protein
Submitted name:

CCR4-NOT transcription complex subunit 3, isoform A

Gene

Not3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, RepressorARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CCR4-NOT transcription complex subunit 3, isoform AImported
Submitted name:
CCR4-NOT transcription complex subunit 3, isoform BImported (EC:3.1.13.4Imported)
Submitted name:
LD13864pImported
Submitted name:
MIP07457pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Not3Imported
Synonyms:5Imported, CNOT3Imported, Dmel\CG8426Imported, dNot3Imported, l(2)NC136Imported, l(2)NC136-RAImported, NOT3Imported, not3Imported, NOT3.5Imported
ORF Names:CG8426Imported, Dmel_CG8426Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0033029, Not3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0033029

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033029, Expressed in central nervous system and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7K126, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304299

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 233Not3InterPro annotationAdd BLAST230
Domaini713 – 838NOT2_3_5InterPro annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni243 – 274DisorderedSequence analysisAdd BLAST32
Regioni316 – 336DisorderedSequence analysisAdd BLAST21
Regioni350 – 381DisorderedSequence analysisAdd BLAST32
Regioni418 – 459DisorderedSequence analysisAdd BLAST42
Regioni582 – 668DisorderedSequence analysisAdd BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili46 – 73Sequence analysisAdd BLAST28
Coiled coili137 – 157Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi316 – 335Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT2/3/5 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2150, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013819_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKTWAAG

Database of Orthologous Groups

More...
OrthoDBi
1109812at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.1020, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR012270, CCR4-NOT_su3/5
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C
IPR007207, Not_N

The PANTHER Classification System

More...
PANTHERi
PTHR23326, PTHR23326, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04153, NOT2_3_5, 1 hit
PF04065, Not3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005290, NOT_su_3_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7K126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATRKLQGE IDRCLKKVAE GVETFEDIWK KVHNATNTNQ KQKHLQEKYE
60 70 80 90 100
ADLKKEIKKL QRLRDQIKSW IASAEIKDKS SLLENRRLIE TQMERFKVVE
110 120 130 140 150
RETKTKAYSK EGLGAAQKMD PAQRIKDDAR NWLTSSISSL QIQIDQYESE
160 170 180 190 200
IESLLAGKKK RLDRDKQERM DDLRGKLDRH KFHITKLETL LRLLDNDGVE
210 220 230 240 250
AEQVNKIKDD VEYYIDSSQE PDFEENEFIY DDIIGLDEVE LSGTATTDSN
260 270 280 290 300
NSNETSGSPS SVTSGGSPSQ SPVTVQQILN TSSQGAASSG SSAASAALFQ
310 320 330 340 350
QQLTAAQSNG NNVGYASDTS AASSSATTST DPAGGTVAVN CVGGLADKRN
360 370 380 390 400
KSSESNALKL KPQPHQLIKP TPVRATAKLP LSSDTQVNKI VSSTPSKNQQ
410 420 430 440 450
QLPTAASIVA TSAMQSQSSI GSCSSTGGTG ASQSASSGNN PGNNPAVQPN
460 470 480 490 500
APTPGQSGIA AAAASTNVVS ATIVSSANVQ GQSVIQPTPT IAFAAVAKHN
510 520 530 540 550
TSLLENGPVL QQQLAVTPTV AAIVGAGTQA QQKHVPPLSN LQTNSPHIQN
560 570 580 590 600
GLPVSDSTND NSCNVVDTIS LKTMAQDAIN RSAIDPNSLN QQQTSSIDLR
610 620 630 640 650
QPQSQKSLLQ HFNSETNTNQ QQLTSQQQQQ LQNNSLAATT GSNNGTSTGS
660 670 680 690 700
GLMNVANATG QPISGNAKTH ACQPQQMATT EAHIPTLLGV TPLGPTPLQK
710 720 730 740 750
EHQMQFQMME AAYYHLPQPM DTEKLQTYFH RAPVLTPSHY PQAQMPIYDT
760 770 780 790 800
VEFYQRLSTE TLFFVFYYME GSKAQYLAAK ALKKQSWRFH TKYMMWFQRH
810 820 830 840
EEPKIINDDY EQGTYIYFDY EKWSQRKKEG FTFEYKYLED KELN
Length:844
Mass (Da):92,368
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE641D257330EE36
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57324.2
AY069428 mRNA Translation: AAL39573.1
BT083390 mRNA Translation: ACQ66051.1
AE013599 Genomic DNA Translation: AGB93247.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260712.1, NM_001273783.1
NP_610176.1, NM_136332.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086062; FBpp0085398; FBgn0033029
FBtr0331970; FBpp0304299; FBgn0033029

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35501

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8426

UCSC genome browser

More...
UCSCi
CG8426-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57324.2
AY069428 mRNA Translation: AAL39573.1
BT083390 mRNA Translation: ACQ66051.1
AE013599 Genomic DNA Translation: AGB93247.1
RefSeqiNP_001260712.1, NM_001273783.1
NP_610176.1, NM_136332.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7K126, 5 interactors
STRINGi7227.FBpp0304299

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
35501

Genome annotation databases

EnsemblMetazoaiFBtr0086062; FBpp0085398; FBgn0033029
FBtr0331970; FBpp0304299; FBgn0033029
GeneIDi35501
KEGGidme:Dmel_CG8426
UCSCiCG8426-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35501
FlyBaseiFBgn0033029, Not3
VEuPathDBiVectorBase:FBgn0033029

Phylogenomic databases

eggNOGiKOG2150, Eukaryota
GeneTreeiENSGT00390000014743
HOGENOMiCLU_013819_1_0_1
OMAiIKTWAAG
OrthoDBi1109812at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35501, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Not3, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35501

Protein Ontology

More...
PROi
PR:Q7K126

Gene expression databases

BgeeiFBgn0033029, Expressed in central nervous system and 38 other tissues

Family and domain databases

Gene3Di2.30.30.1020, 1 hit
InterProiView protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR012270, CCR4-NOT_su3/5
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C
IPR007207, Not_N
PANTHERiPTHR23326, PTHR23326, 2 hits
PfamiView protein in Pfam
PF04153, NOT2_3_5, 1 hit
PF04065, Not3, 1 hit
PIRSFiPIRSF005290, NOT_su_3_5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7K126_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7K126
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: January 19, 2022
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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