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Protein
Submitted name:

LD20892p

Gene

Myd88

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase
  • TIR domain binding Source: InterPro
  • Toll binding Source: FlyBase

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DME-1810476 RIP-mediated NFkB activation via ZBP1
R-DME-209442 Formation of the trans-membrane 'signalling complex'
R-DME-214842 DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844 DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214862 Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
R-DME-214863 Adaptor protein complex binds to TL receptor at the plasma membrane
R-DME-214869 Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-214874 PLL kinase binds to TUB in the TL receptor 'signalling complex'
R-DME-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-933542 TRAF6 mediated NF-kB activation
R-DME-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-DME-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-DME-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyi

Protein namesi
Submitted name:
LD20892pImported
Submitted name:
MyD88 adapter proteinImported
Submitted name:
Myd88, isoform AImported
Submitted name:
Myd88, isoform BImported
Submitted name:
Myd88, isoform CImported
Gene namesi
Name:Myd88Imported
ORF Names:CG2078Imported, Dmel_CG2078Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033402 Myd88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0033402 Expressed in 39 organ(s), highest expression level in spermathecum

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TlP089533EBI-129988,EBI-143610

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7K105, 5 interactors
STRINGi7227.FBpp0305215

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 341TIRInterPro annotationAdd BLAST101

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
HOGENOMiHOG000243425
KOiK04729
OMAiNFWDKLA
OrthoDBiEOG091G0NDI

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF13676 TIR_2, 1 hit
SMARTiView protein in SMART
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q7K105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPRFVCHQQ HSVAHSHYQP HSHFHHHTHR HPNPPHHHHI YGATDVSYRR
60 70 80 90 100
YRTAGMVVAE GVMDSGSGSG TGTGLGHFNE TPLSALGIET RTQLSRMLNR
110 120 130 140 150
KKVLRSEEGY QRDWRGISEL AKQKGFVDEN ANNPMDLVLI SWSQRSPQTA
160 170 180 190 200
KVGHLEHFLG IIDRWDVCDD IQENLAKDTQ RFIMKQEQRQ TALVEACPPP
210 220 230 240 250
PSDCFETNNN YSSSNNITVG QSVQILSDED QRCVQMGQPL PRYNACVLYA
260 270 280 290 300
EADIDHATEI MNNLESERYN LRLFLRHRDM LMGVPFEHVQ LSHFMATRCN
310 320 330 340 350
HLIVVLTEEF LRSPENTYLV NFTQKIQIEN HTRKIIPILY KTDMHIPQTL
360 370 380 390 400
GIYTHIKYAG DSKLFNFWDK LARSLHDLDA FSIYSTRQVQ TPSPVEESAP
410 420 430 440 450
RVTTPSIRIQ INDKDVTDMP NYNSCKVPEA ETTIVSVSGD TGSPLPEHKP
460 470 480 490 500
KKKDRFLRRI THSFGKTARS DGASGKTLRH AHSVSTINVT ERERTLSASS
510 520 530
SNISTTSESK KSFIKWQPNI LKKALFSRSS SKLQTPG
Length:537
Mass (Da):61,163
Last modified:October 3, 2006 - v1
Checksum:i4AA9E9F89EF2D79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58953.1
AY069468 mRNA Translation: AAL39613.1
AF422803 mRNA Translation: AAL56570.1
AE013599 Genomic DNA Translation: AGB93354.1
AE013599 Genomic DNA Translation: AHN56044.1
RefSeqiNP_001260821.1, NM_001273892.1
NP_001286246.1, NM_001299317.1
NP_610479.1, NM_136635.3
UniGeneiDm.2113

Genome annotation databases

EnsemblMetazoaiFBtr0088598; FBpp0087679; FBgn0033402
FBtr0333000; FBpp0305215; FBgn0033402
FBtr0345024; FBpp0311274; FBgn0033402
GeneIDi35956
KEGGidme:Dmel_CG2078
UCSCiCG2078-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58953.1
AY069468 mRNA Translation: AAL39613.1
AF422803 mRNA Translation: AAL56570.1
AE013599 Genomic DNA Translation: AGB93354.1
AE013599 Genomic DNA Translation: AHN56044.1
RefSeqiNP_001260821.1, NM_001273892.1
NP_001286246.1, NM_001299317.1
NP_610479.1, NM_136635.3
UniGeneiDm.2113

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7K105, 5 interactors
STRINGi7227.FBpp0305215

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088598; FBpp0087679; FBgn0033402
FBtr0333000; FBpp0305215; FBgn0033402
FBtr0345024; FBpp0311274; FBgn0033402
GeneIDi35956
KEGGidme:Dmel_CG2078
UCSCiCG2078-RA d. melanogaster

Organism-specific databases

CTDi4615
FlyBaseiFBgn0033402 Myd88

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
HOGENOMiHOG000243425
KOiK04729
OMAiNFWDKLA
OrthoDBiEOG091G0NDI

Enzyme and pathway databases

ReactomeiR-DME-1810476 RIP-mediated NFkB activation via ZBP1
R-DME-209442 Formation of the trans-membrane 'signalling complex'
R-DME-214842 DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844 DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214862 Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
R-DME-214863 Adaptor protein complex binds to TL receptor at the plasma membrane
R-DME-214869 Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-214874 PLL kinase binds to TUB in the TL receptor 'signalling complex'
R-DME-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-933542 TRAF6 mediated NF-kB activation
R-DME-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-DME-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-DME-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

GenomeRNAii35956
PROiPR:Q7K105

Gene expression databases

BgeeiFBgn0033402 Expressed in 39 organ(s), highest expression level in spermathecum

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF13676 TIR_2, 1 hit
SMARTiView protein in SMART
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7K105_DROME
AccessioniPrimary (citable) accession number: Q7K105
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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