UniProtKB - Q7K0S9 (GLIS2_DROME)
Protein
Zinc finger protein GLIS2 homolog
Gene
sug
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Transcription factor which represses a set of lipase genes involved in fat catabolism.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 128 – 153 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 163 – 190 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 196 – 218 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 224 – 248 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 254 – 280 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cellular response to nutrient Source: FlyBase
- central nervous system development Source: GO_Central
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to starvation Source: FlyBase
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein GLIS2 homologAlternative name(s): Protein sugarbabe |
Gene namesi | Name:sug ORF Names:CG3850 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0033782, sug |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear speck Source: UniProtKB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286986 | 1 – 384 | Zinc finger protein GLIS2 homologAdd BLAST | 384 |
Proteomic databases
PaxDbi | Q7K0S9 |
Expressioni
Developmental stagei
Specifically expressed in gut, fat body and Malpighian tubules of sugar-fed larvae.1 Publication
Inductioni
Strongly and rapidly induced in larvae by maltose, trehalose, glucose, fructose or saccharose, but not by lactose or galactose.1 Publication
Gene expression databases
Bgeei | FBgn0033782, Expressed in head and 37 other tissues |
ExpressionAtlasi | Q7K0S9, baseline and differential |
Genevisiblei | Q7K0S9, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 62194, 22 interactors |
IntActi | Q7K0S9, 17 interactors |
STRINGi | 7227.FBpp0086902 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 50 – 64 | Gln-richAdd BLAST | 15 | |
Compositional biasi | 113 – 120 | Poly-Ser | 8 | |
Compositional biasi | 318 – 324 | Poly-Ser | 7 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 128 – 153 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 163 – 190 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 196 – 218 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 224 – 248 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 254 – 280 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158383 |
InParanoidi | Q7K0S9 |
PhylomeDBi | Q7K0S9 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7K0S9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIIQKSIFN SGPHSRGIYE PPLGYFTPYN TPPYIAAYSD SGSWLADHHQ
60 70 80 90 100
HHQQQHQQHQ QQMQHIRFPT PPITPPRPIA GYGYRQRTQS VIMKARGQQD
110 120 130 140 150
ELCRSPVEFP DDSKSCSSSS ECGTASDFVC NWTDCDRVFD TLDALAQHVT
160 170 180 190 200
QRHAIASLTD GLYYCRWRGC QRSERGFNAR YKMLVHTRTH TKEKPHRCHL
210 220 230 240 250
CEKSFSRAEN LKIHIRSHSG EKPYKCSFEG CQKAYSNSSD RFKHTRTHSM
260 270 280 290 300
EKPYMCKVAG CQKRYTDPSS LRKHVKTFKH SIHLIASQPL TLPSVPCLLE
310 320 330 340 350
ASSESAFTCL PAASSVESTS SSSSARYYDD SNNEPSDYSL KPKQDAEFSP
360 370 380
SYWLGDRQHS YLHSEDFFVK MDVESPLDLR IHRI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KEP0 | A0A0B4KEP0_DROME | Sugarbabe, isoform B | sug Dmel\CG3850, CG3850, Dmel_CG3850 | 322 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58441.1 AY069605 mRNA Translation: AAL39750.1 |
RefSeqi | NP_610826.1, NM_136982.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0087789; FBpp0086902; FBgn0033782 |
GeneIDi | 36424 |
KEGGi | dme:Dmel_CG3850 |
UCSCi | CG3850-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58441.1 AY069605 mRNA Translation: AAL39750.1 |
RefSeqi | NP_610826.1, NM_136982.3 |
3D structure databases
SMRi | Q7K0S9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62194, 22 interactors |
IntActi | Q7K0S9, 17 interactors |
STRINGi | 7227.FBpp0086902 |
Proteomic databases
PaxDbi | Q7K0S9 |
Genome annotation databases
EnsemblMetazoai | FBtr0087789; FBpp0086902; FBgn0033782 |
GeneIDi | 36424 |
KEGGi | dme:Dmel_CG3850 |
UCSCi | CG3850-RA, d. melanogaster |
Organism-specific databases
CTDi | 36424 |
FlyBasei | FBgn0033782, sug |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158383 |
InParanoidi | Q7K0S9 |
PhylomeDBi | Q7K0S9 |
Miscellaneous databases
BioGRID-ORCSi | 36424, 0 hits in 1 CRISPR screen |
GenomeRNAii | 36424 |
PROi | PR:Q7K0S9 |
Gene expression databases
Bgeei | FBgn0033782, Expressed in head and 37 other tissues |
ExpressionAtlasi | Q7K0S9, baseline and differential |
Genevisiblei | Q7K0S9, DM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLIS2_DROME | |
Accessioni | Q7K0S9Primary (citable) accession number: Q7K0S9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 10, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families