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UniProtKB - Q7K0L4 (WDR26_DROME)
Protein
WD repeat-containing protein 26 homolog
Gene
CG7611
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
G-beta-like protein involved in cell signal transduction (By similarity).
By similarityGO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 26 homolog |
Gene namesi | ORF Names:CG7611 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0037094, CG7611 |
VEuPathDBi | VectorBase:FBgn0037094 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
- GID complex Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280739 | 1 – 630 | WD repeat-containing protein 26 homologAdd BLAST | 630 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | Phosphoserine1 Publication | 1 | |
Modified residuei | 40 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q7K0L4 |
PRIDEi | Q7K0L4 |
PTM databases
iPTMneti | Q7K0L4 |
Expressioni
Gene expression databases
Bgeei | FBgn0037094, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | Q7K0L4, baseline and differential |
Genevisiblei | Q7K0L4, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 65631, 19 interactors |
IntActi | Q7K0L4, 10 interactors |
STRINGi | 7227.FBpp0078015 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 128 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 129 – 190 | CTLHPROSITE-ProRule annotationAdd BLAST | 62 | |
Repeati | 312 – 351 | WD 1Add BLAST | 40 | |
Repeati | 359 – 400 | WD 2Add BLAST | 42 | |
Repeati | 404 – 443 | WD 3Add BLAST | 40 | |
Repeati | 445 – 482 | WD 4Add BLAST | 38 | |
Repeati | 485 – 524 | WD 5Add BLAST | 40 | |
Repeati | 529 – 569 | WD 6Add BLAST | 41 | |
Repeati | 572 – 612 | WD 7Add BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 604 – 630 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 29 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 45 – 90 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 605 – 630 | Polar residuesSequence analysisAdd BLAST | 26 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
HOGENOMi | CLU_000288_57_25_1 |
InParanoidi | Q7K0L4 |
OMAi | YCKFSPD |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q7K0L4 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00667, LisH, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7K0L4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSTSSTSSG SCSRPLEGST LNSGGSAENV ARDGGSGDDS VGIGDENPSG
60 70 80 90 100
SSAATNGHDS KHNGFIVNNN GSSSRIVDGE NNRENTSCSG VQLDKSNQEI
110 120 130 140 150
IRLIGQYLHD VGLDKSVQTL MLESGCYLEH PSATKFREHV LMGDWSKADS
160 170 180 190 200
DLKDLEPLID NGKLATITEM KFILLEQKYL EHLDDGNPLD ALHVLRSELT
210 220 230 240 250
PLQHNITRVH QLSSYMMCST NQDLYQRAKW EGKGILSRAL VMERLQTFMP
260 270 280 290 300
PSVMMSPRRL RTLLQQAVEL QSQHCPCHDM AWETNLETVS LLTDHCCTTD
310 320 330 340 350
GFPMQTIQIL TDHCDEVWFC KFSPDGLKLA TGSKDSTVII WDVDPYKLTL
360 370 380 390 400
KHRRVLDGQA QLSVSFVSWS PDSKLILVGG TEDSHELYIW NVDDGKLVVK
410 420 430 440 450
FSQSLEDSLA CGAFSRDGAR FVCGGQKGQL YLCDLNGTIV DSWEGVRVNS
460 470 480 490 500
IAFRADNKTI LAADNHYRIR GYNFDSPRSD FDILREPHPI MTFSINSADR
510 520 530 540 550
LALLNVSNQG LHLWDIEDKC LVRRFQGIRQ SNFAIHSCFG GVNESFVASG
560 570 580 590 600
SEDKVVYIWH IKREEPLAKL AGHTKTVNCV SWNPVYPSLL ASASDDATVR
610 620 630
IWGPKPNGSS ATTESDDCSS SSSSSSWNMT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE1JHX5 | E1JHX5_DROME | Uncharacterized protein, isoform B | Dmel\CG7611 WDR26, CG7611, Dmel_CG7611 | 630 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF51739.2 AE014296 Genomic DNA Translation: AAG22181.1 AE014296 Genomic DNA Translation: AAG22182.2 AE014296 Genomic DNA Translation: AAN12172.1 AE014296 Genomic DNA Translation: AAN12173.1 AE014296 Genomic DNA Translation: AAN12174.1 AE014296 Genomic DNA Translation: AAN12175.1 AY069717 mRNA Translation: AAL39862.1 |
RefSeqi | NP_001163489.1, NM_001170018.2 NP_649326.1, NM_141069.4 NP_730644.1, NM_168913.3 NP_730645.1, NM_168914.3 NP_730646.1, NM_168915.3 NP_730647.1, NM_168916.3 NP_730648.1, NM_168917.3 NP_730649.1, NM_168918.3 NP_730650.1, NM_168919.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0078359; FBpp0078015; FBgn0037094 FBtr0078361; FBpp0078017; FBgn0037094 FBtr0078362; FBpp0078018; FBgn0037094 FBtr0078363; FBpp0078019; FBgn0037094 FBtr0078364; FBpp0078020; FBgn0037094 FBtr0078365; FBpp0078021; FBgn0037094 FBtr0078366; FBpp0078022; FBgn0037094 FBtr0301197; FBpp0290415; FBgn0037094 FBtr0301198; FBpp0290416; FBgn0037094 |
GeneIDi | 40386 |
KEGGi | dme:Dmel_CG7611 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF51739.2 AE014296 Genomic DNA Translation: AAG22181.1 AE014296 Genomic DNA Translation: AAG22182.2 AE014296 Genomic DNA Translation: AAN12172.1 AE014296 Genomic DNA Translation: AAN12173.1 AE014296 Genomic DNA Translation: AAN12174.1 AE014296 Genomic DNA Translation: AAN12175.1 AY069717 mRNA Translation: AAL39862.1 |
RefSeqi | NP_001163489.1, NM_001170018.2 NP_649326.1, NM_141069.4 NP_730644.1, NM_168913.3 NP_730645.1, NM_168914.3 NP_730646.1, NM_168915.3 NP_730647.1, NM_168916.3 NP_730648.1, NM_168917.3 NP_730649.1, NM_168918.3 NP_730650.1, NM_168919.3 |
3D structure databases
SMRi | Q7K0L4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 65631, 19 interactors |
IntActi | Q7K0L4, 10 interactors |
STRINGi | 7227.FBpp0078015 |
PTM databases
iPTMneti | Q7K0L4 |
Proteomic databases
PaxDbi | Q7K0L4 |
PRIDEi | Q7K0L4 |
Protocols and materials databases
DNASUi | 40386 |
Genome annotation databases
EnsemblMetazoai | FBtr0078359; FBpp0078015; FBgn0037094 FBtr0078361; FBpp0078017; FBgn0037094 FBtr0078362; FBpp0078018; FBgn0037094 FBtr0078363; FBpp0078019; FBgn0037094 FBtr0078364; FBpp0078020; FBgn0037094 FBtr0078365; FBpp0078021; FBgn0037094 FBtr0078366; FBpp0078022; FBgn0037094 FBtr0301197; FBpp0290415; FBgn0037094 FBtr0301198; FBpp0290416; FBgn0037094 |
GeneIDi | 40386 |
KEGGi | dme:Dmel_CG7611 |
Organism-specific databases
FlyBasei | FBgn0037094, CG7611 |
VEuPathDBi | VectorBase:FBgn0037094 |
Phylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
HOGENOMi | CLU_000288_57_25_1 |
InParanoidi | Q7K0L4 |
OMAi | YCKFSPD |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q7K0L4 |
Miscellaneous databases
BioGRID-ORCSi | 40386, 0 hits in 1 CRISPR screen |
GenomeRNAii | 40386 |
PROi | PR:Q7K0L4 |
Gene expression databases
Bgeei | FBgn0037094, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | Q7K0L4, baseline and differential |
Genevisiblei | Q7K0L4, DM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR020472, G-protein_beta_WD-40_rep IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 3 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00667, LisH, 1 hit SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR26_DROME | |
Accessioni | Q7K0L4Primary (citable) accession number: Q7K0L4 Secondary accession number(s): A4V292 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase