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Protein

Phosphotransferase

Gene

Hex-C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular glucose homeostasis Source: GO_Central
  • glucose homeostasis Source: FlyBase
  • glycolytic process Source: GO_Central

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processGlycolysisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphotransferaseUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:Hex-CImported
ORF Names:CG8094Imported, Dmel_CG8094Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001187 Hex-C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0001187 Expressed in 21 organ(s), highest expression level in capitellum (Drosophila)

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086530

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 200Hexokinase_1InterPro annotationAdd BLAST195
Domaini207 – 449Hexokinase_2InterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
KOiK00844
OMAiCRVGVIV
OrthoDBiEOG091G08MD

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7JYW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT
60 70 80 90 100
YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL
110 120 130 140 150
MVGPGVDLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQLGLKEGIL
160 170 180 190 200
VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA
210 220 230 240 250
HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKTKRS VIVNAEWGAF
260 270 280 290 300
GEGGQLDFVR TEYDREVDEK SLNRSEQLFE KMTAGMYLGN LVRLVLLRAL
310 320 330 340 350
ERKLIFKQSS RRPEFASVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK
360 370 380 390 400
NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG
410 420 430 440 450
MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA

SKTK
Length:454
Mass (Da):50,738
Last modified:October 3, 2006 - v1
Checksum:i57B3E6254F63710F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58160.1
AF237469 mRNA Translation: AAG10690.1
AF257540 Genomic DNA Translation: AAG23064.1
AF257541 Genomic DNA Translation: AAG23065.1
AF257543 Genomic DNA Translation: AAG23067.1
AF257546 Genomic DNA Translation: AAG23070.1
AF257547 Genomic DNA Translation: AAG23071.1
AF257549 Genomic DNA Translation: AAG23073.1
AF257551 Genomic DNA Translation: AAG23075.1
AF257554 Genomic DNA Translation: AAG23078.1
AF257555 Genomic DNA Translation: AAG23079.1
AF257558 Genomic DNA Translation: AAG23082.1
AF257561 Genomic DNA Translation: AAG23085.1
AF257564 Genomic DNA Translation: AAG23088.1
AF257565 Genomic DNA Translation: AAG23089.1
AF257567 Genomic DNA Translation: AAG23091.1
AF257568 Genomic DNA Translation: AAG23092.1
AF257570 Genomic DNA Translation: AAG23094.1
AF257571 Genomic DNA Translation: AAG23095.1
AF257573 Genomic DNA Translation: AAG23097.1
AF257574 Genomic DNA Translation: AAG23098.1
AF257575 Genomic DNA Translation: AAG23099.1
AF257576 Genomic DNA Translation: AAG23100.1
AF257577 Genomic DNA Translation: AAG23101.1
AF257578 Genomic DNA Translation: AAG23102.1
AF257581 Genomic DNA Translation: AAG23105.1
AF257582 Genomic DNA Translation: AAG23106.1
AF257583 Genomic DNA Translation: AAG23107.1
AF257585 Genomic DNA Translation: AAG23109.1
AF257587 Genomic DNA Translation: AAG23111.1
AF257588 Genomic DNA Translation: AAG23112.1
AF257589 Genomic DNA Translation: AAG23113.1
AY070657 mRNA Translation: AAL48128.1
AY071719 mRNA Translation: AAL49341.1
AJ309864 Genomic DNA Translation: CAC34564.1
RefSeqiNP_524674.1, NM_079935.4
UniGeneiDm.1873

Genome annotation databases

EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187
GeneIDi44008
KEGGidme:Dmel_CG8094
UCSCiCG8094-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58160.1
AF237469 mRNA Translation: AAG10690.1
AF257540 Genomic DNA Translation: AAG23064.1
AF257541 Genomic DNA Translation: AAG23065.1
AF257543 Genomic DNA Translation: AAG23067.1
AF257546 Genomic DNA Translation: AAG23070.1
AF257547 Genomic DNA Translation: AAG23071.1
AF257549 Genomic DNA Translation: AAG23073.1
AF257551 Genomic DNA Translation: AAG23075.1
AF257554 Genomic DNA Translation: AAG23078.1
AF257555 Genomic DNA Translation: AAG23079.1
AF257558 Genomic DNA Translation: AAG23082.1
AF257561 Genomic DNA Translation: AAG23085.1
AF257564 Genomic DNA Translation: AAG23088.1
AF257565 Genomic DNA Translation: AAG23089.1
AF257567 Genomic DNA Translation: AAG23091.1
AF257568 Genomic DNA Translation: AAG23092.1
AF257570 Genomic DNA Translation: AAG23094.1
AF257571 Genomic DNA Translation: AAG23095.1
AF257573 Genomic DNA Translation: AAG23097.1
AF257574 Genomic DNA Translation: AAG23098.1
AF257575 Genomic DNA Translation: AAG23099.1
AF257576 Genomic DNA Translation: AAG23100.1
AF257577 Genomic DNA Translation: AAG23101.1
AF257578 Genomic DNA Translation: AAG23102.1
AF257581 Genomic DNA Translation: AAG23105.1
AF257582 Genomic DNA Translation: AAG23106.1
AF257583 Genomic DNA Translation: AAG23107.1
AF257585 Genomic DNA Translation: AAG23109.1
AF257587 Genomic DNA Translation: AAG23111.1
AF257588 Genomic DNA Translation: AAG23112.1
AF257589 Genomic DNA Translation: AAG23113.1
AY070657 mRNA Translation: AAL48128.1
AY071719 mRNA Translation: AAL49341.1
AJ309864 Genomic DNA Translation: CAC34564.1
RefSeqiNP_524674.1, NM_079935.4
UniGeneiDm.1873

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086530

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187
GeneIDi44008
KEGGidme:Dmel_CG8094
UCSCiCG8094-RA d. melanogaster

Organism-specific databases

CTDi44008
FlyBaseiFBgn0001187 Hex-C

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
KOiK00844
OMAiCRVGVIV
OrthoDBiEOG091G08MD

Enzyme and pathway databases

ReactomeiR-DME-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis

Miscellaneous databases

GenomeRNAii44008

Gene expression databases

BgeeiFBgn0001187 Expressed in 21 organ(s), highest expression level in capitellum (Drosophila)

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS51748 HEXOKINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7JYW9_DROME
AccessioniPrimary (citable) accession number: Q7JYW9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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