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Entry version 140 (02 Dec 2020)
Sequence version 1 (03 Oct 2006)
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Protein

Nucleolar GTP-binding protein 2

Gene

Ns2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • compound eye morphogenesis Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ns2Imported
Synonyms:Dmel\CG6501Imported, dmNS2Imported, NgpImported, Ngp1Imported, NS2Imported, ns2Imported
ORF Names:CG6501Imported, Dmel_CG6501Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034243, Ns2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034243, Expressed in female gonad and 57 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q7JXU4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086063

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 373CP-type GInterPro annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni475 – 500DisorderedSequence analysisAdd BLAST26
Regioni546 – 674DisorderedSequence analysisAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili165 – 185Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 26PolarSequence analysisAdd BLAST17
Compositional biasi546 – 563PolyampholyteSequence analysisAdd BLAST18
Compositional biasi564 – 578AcidicSequence analysisAdd BLAST15
Compositional biasi623 – 637PolarSequence analysisAdd BLAST15
Compositional biasi638 – 653PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2423, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00810000125524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011106_4_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEPTPKW

Database of Orthologous Groups

More...
OrthoDBi
1210675at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1580.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030378, G_CP_dom
IPR023179, GTP-bd_ortho_bundle_sf
IPR006073, GTP_binding_domain
IPR024929, NOG2
IPR012971, NOG2_N_dom
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR11089:SF9, PTHR11089:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01926, MMR_HSR1, 1 hit
PF08153, NGP1NT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326, GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51721, G_CP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7JXU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKVRSTPGK PRTQGFNHSN HSMNPERPKS GLKGVAHPRT KGTIKRLQMY
60 70 80 90 100
RNFKAKRDRT GKILTPAPFQ GRLPAGTMAR VEPTPKWFSN SRVISQTALQ
110 120 130 140 150
KFQDEIGKAV KDPYQVIMKP SQLPVTLLNE AAKYKRVHLL DTESFDSTFG
160 170 180 190 200
PKKQRKRVSL KVRDLEDLSK AADDQADKYD SAKDLDLIRE DTGEKKAVRD
210 220 230 240 250
WVFGAGQSKR IWNELHKVVD ASDVLLQVLD ARDPMGTRSK YIEEFLRKEK
260 270 280 290 300
PHKHLFFILN KVDLVPVWVT QRWVAILSAE YPTIAFHASL QHPFGKGALI
310 320 330 340 350
NLFRQLGKLH LDKKQISVGF IGYPNVGKSS VINALRSKKV CKVAPIAGET
360 370 380 390 400
KVWQYITLMK RIFLIDCPGV VYPTAETDTE KVLKGVVRVE LVTNPEDYVD
410 420 430 440 450
SLLKRVRPEY ISKNYKIEHW NTSTHFLEQL AQKTGKLLKG GEPDVTVTAR
460 470 480 490 500
MVLNDWQRGK LPFYVPPEGF AVPKSQEGKE EEVVAEDPNE DAKSEAPTFV
510 520 530 540 550
SESVKKAREF KQIQDFRKIR VGLEYEQEDV KDLDHIDLEL LEQQKAERAA
560 570 580 590 600
KKKARIHNLG EEDEESSDGA DEFYSEDEYN EDLQRVVHKK AKSKKPQQLA
610 620 630 640 650
ITSSGKFRVA KIQPGDSDGA GSSDDDGPST SKAPRLTAKQ KRSLERSQKR
660 670
KKIGSNFYET TNVKNRNRNK KKDA
Length:674
Mass (Da):76,607
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32F7AA827FFEB18E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57834.1
AF315579 mRNA Translation: AAL26879.1
AY089700 mRNA Translation: AAL90438.1

NCBI Reference Sequences

More...
RefSeqi
NP_611232.1, NM_137388.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086906; FBpp0086063; FBgn0034243

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6501

UCSC genome browser

More...
UCSCi
CG6501-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57834.1
AF315579 mRNA Translation: AAL26879.1
AY089700 mRNA Translation: AAL90438.1
RefSeqiNP_611232.1, NM_137388.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7JXU4, 4 interactors
STRINGi7227.FBpp0086063

Genome annotation databases

EnsemblMetazoaiFBtr0086906; FBpp0086063; FBgn0034243
GeneIDi36989
KEGGidme:Dmel_CG6501
UCSCiCG6501-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57762
FlyBaseiFBgn0034243, Ns2

Phylogenomic databases

eggNOGiKOG2423, Eukaryota
GeneTreeiENSGT00810000125524
HOGENOMiCLU_011106_4_1_1
OMAiVEPTPKW
OrthoDBi1210675at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36989, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36989

Gene expression databases

BgeeiFBgn0034243, Expressed in female gonad and 57 other tissues

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378, G_CP_dom
IPR023179, GTP-bd_ortho_bundle_sf
IPR006073, GTP_binding_domain
IPR024929, NOG2
IPR012971, NOG2_N_dom
IPR027417, P-loop_NTPase
PANTHERiPTHR11089:SF9, PTHR11089:SF9, 1 hit
PfamiView protein in Pfam
PF01926, MMR_HSR1, 1 hit
PF08153, NGP1NT, 1 hit
PRINTSiPR00326, GTP1OBG
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721, G_CP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7JXU4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JXU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: December 2, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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