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Entry version 135 (02 Jun 2021)
Sequence version 1 (03 Oct 2006)
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Protein

Nuclear pore glycoprotein p62

Gene

Nup62

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the nuclear pore complex (By similarity).

The N-terminal is probably involved in nucleocytoplasmic transport (By similarity).

The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity).

Binds to transcriptionally active genes (PubMed:20144760).

Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • phospholipid binding Source: GO_Central
  • structural constituent of nuclear pore Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore glycoprotein p62Curated
Alternative name(s):
62 kDa nucleoporinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup62Imported
ORF Names:CG6251Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034118, Nup62

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in oocytes results in increased nuclear size. RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery disrupting karyosome morphology. Simultaneous RNAi-mediated knockdown of nucleoporin Nup154 restores normal karyosome formation.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004397671 – 394Nuclear pore glycoprotein p62Add BLAST394

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7JXF5

PRoteomics IDEntifications database

More...
PRIDEi
Q7JXF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult male accessory glands (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034118, Expressed in imaginal disc and 49 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7JXF5, 7 interactors

Molecular INTeraction database

More...
MINTi
Q7JXF5

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0086294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7JXF5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati22 – 231Curated2
Repeati50 – 512Curated2
Repeati75 – 763Curated2
Repeati77 – 784Curated2
Repeati116 – 1175Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 1175 X 2 AA repeats of F-GCuratedAdd BLAST96
Regioni44 – 73DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili211 – 341Sequence analysisAdd BLAST131

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin NSP1/NUP62 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2196, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167119

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025936_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7JXF5

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMMSKQV

Database of Orthologous Groups

More...
OrthoDBi
1145183at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7JXF5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026010, NSP1/NUP62
IPR007758, Nucleoporin_NSP1_C

The PANTHER Classification System

More...
PANTHERi
PTHR12084, PTHR12084, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05064, Nsp1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7JXF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFQLPTTTA APTGGATSSF SFGLSTGTPA AAPASGAATT APATKTTFSF
60 70 80 90 100
GTPAPTAGIG GGDADNSKAQ APPAFGFGLG SGTASAPLTL GTQAAANPAS
110 120 130 140 150
TTSATATGTS AAPPAFGGFT AQPAASVVPT IATSAPNTAA TTTGLLGGSG
160 170 180 190 200
LGAPKTTAAA STTLTAAPSA IASTQGAAPA PTLSTGGAFA NLTTETKTTD
210 220 230 240 250
SSAVSTASQL SYHQLEEHIN KWTLEFEEQE KVFTEQATQI NAWDKLLISN
260 270 280 290 300
NGKIVELNDA VKKVKTDQQV LDQELEFIAT QQKELEDSLG PLEKEFVNLP
310 320 330 340 350
RVDMERSQTY LMVENLDTQL KQMSEDLKEI IDNLNEANKG QDTTDPIIQI
360 370 380 390
GKILNAHMNS LQWIESQSTN ISKKLEDIGK IQDSQKRDIF RAPF
Length:394
Mass (Da):40,684
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D3C1E3A149ECCE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58007.1
AE013599 Genomic DNA Translation: AHN56285.1
AY094707 mRNA Translation: AAM11060.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286489.1, NM_001299560.1
NP_611120.1, NM_137276.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087150; FBpp0086294; FBgn0034118
FBtr0340060; FBpp0309066; FBgn0034118

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6251

UCSC genome browser

More...
UCSCi
CG6251-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58007.1
AE013599 Genomic DNA Translation: AHN56285.1
AY094707 mRNA Translation: AAM11060.1
RefSeqiNP_001286489.1, NM_001299560.1
NP_611120.1, NM_137276.2

3D structure databases

SMRiQ7JXF5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ7JXF5, 7 interactors
MINTiQ7JXF5
STRINGi7227.FBpp0086294

Proteomic databases

PaxDbiQ7JXF5
PRIDEiQ7JXF5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
36830

Genome annotation databases

EnsemblMetazoaiFBtr0087150; FBpp0086294; FBgn0034118
FBtr0340060; FBpp0309066; FBgn0034118
GeneIDi36830
KEGGidme:Dmel_CG6251
UCSCiCG6251-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23636
FlyBaseiFBgn0034118, Nup62

Phylogenomic databases

eggNOGiKOG2196, Eukaryota
GeneTreeiENSGT00940000167119
HOGENOMiCLU_025936_0_0_1
InParanoidiQ7JXF5
OMAiEMMSKQV
OrthoDBi1145183at2759
PhylomeDBiQ7JXF5

Enzyme and pathway databases

ReactomeiR-DME-159227, Transport of the SLBP independent Mature mRNA
R-DME-159230, Transport of the SLBP Dependant Mature mRNA
R-DME-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453, Regulation of HSF1-mediated heat shock response
R-DME-4551638, SUMOylation of chromatin organization proteins
R-DME-4615885, SUMOylation of DNA replication proteins
R-DME-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36830, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36830

Protein Ontology

More...
PROi
PR:Q7JXF5

Gene expression databases

BgeeiFBgn0034118, Expressed in imaginal disc and 49 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026010, NSP1/NUP62
IPR007758, Nucleoporin_NSP1_C
PANTHERiPTHR12084, PTHR12084, 1 hit
PfamiView protein in Pfam
PF05064, Nsp1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP62_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JXF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: October 3, 2006
Last modified: June 2, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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