Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (26 Feb 2020)
Sequence version 1 (03 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Hormone-sensitive lipase, isoform A

Gene

Hsl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hormone-sensitive lipase, isoform AImported
Submitted name:
Hormone-sensitive lipase, isoform BImported (EC:3.1.1.-Imported)
Submitted name:
Hormone-sensitive lipase, isoform CImported
Submitted name:
RE52776pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HslImported
Synonyms:AImported, anon-56EaImported, dHSLImported, Dmel\CG11055Imported, HSLImported
ORF Names:CG11055Imported, Dmel_CG11055Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034491 Hsl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034491 Expressed in crop (Drosophila) and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7JR83, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085582

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7JR83

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 375HSL_NInterPro annotationAdd BLAST325
Domaini396 – 561Abhydrolase_3InterPro annotationAdd BLAST166
Domaini765 – 827Abhydrolase_3InterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni561 – 626DisorderedSequence analysisAdd BLAST66
Regioni857 – 881DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi561 – 610PolarSequence analysisAdd BLAST50

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4388 Eukaryota
COG0657 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010288_1_0_1

KEGG Orthology (KO)

More...
KOi
K07188

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLAYCPT

Database of Orthologous Groups

More...
OrthoDBi
1263520at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR010468 HSL_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PF06350 HSL_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7JR83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDAASAERA SPQFIALFND NLKLGHEDDG PQAVNGKDTH QHVPADLEAT
60 70 80 90 100
YGTLYAACQD HAAFFARDHT EFGQRLHAAH IAWQDFIVLA NRLVQQIDAF
110 120 130 140 150
AHEYDFDEQT PGNGYRSFIY VTNACIAHGI SICQQLTATR STIFFRKKFY
160 170 180 190 200
MKEVEACSQL LSSLCTCLQY LLILRQWSAS TGDLFACGNH TAEQLFELGD
210 220 230 240 250
TINQYCFYGR CLGFQYGDSI RGVLRFLGIS MASYSESYYS QEGDGPIVKT
260 270 280 290 300
TRSLWTSGKY LMNPELRARR IVNISQNAKI DFCKSFWFLA ESEMMHKLPS
310 320 330 340 350
IVGSSIKVNR LIELPAEPLK LPRRKNFKAS DNLSSDVNQN QGDGDFVEIP
360 370 380 390 400
VPTAHLGPGL PVSVRLLSAR RRSGMLGEGR YRGWHKPIPP SPSILFHCHG
410 420 430 440 450
GGFVAQSSKS HELYLRDWAV ALDCPILSVD YSLAPEAPFP RALQEVYYAY
460 470 480 490 500
CWLLNNTELL GTTAERVVCA GDSAGANLSI GVALKCIEQG VRVPDGLFLA
510 520 530 540 550
YCPTLVSFVP SPARLLCLMD PLLPFGFMMR CLRAYAAPAQ ETLQQNAKQV
560 570 580 590 600
EDAAQIRNVP KSNVGSLNSS RRTSMARSPL SPLEASMNPD DESSDTFASA
610 620 630 640 650
SASYHSQTVE RTDLPHTEGD NSSCVSFEDD SQPIVHYPIE ISADPPKDTA
660 670 680 690 700
SAAYIDNFLD KYLIDTATME VTEETAPEAV QAQANGHAKI SSDDDILVET
710 720 730 740 750
GRDLVAIDTL QGRLQEAVNN ITNTLTRCTQ SYEIHGSNVM AQQDVRNMDA
760 770 780 790 800
LIARSPSEEF AFDVPKDPFL SPYWASDEWL SQLPETKILT LNMDPCLDDC
810 820 830 840 850
VMFAKKLKRL GRQVDLEILE GLPHGFLNFT MLSNEAMEGS KKCIKSLQTL
860 870 880
LQTDSKTKNI DKANSMDEEE SSSPSASLAA S
Length:881
Mass (Da):97,467
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A9043F6765183B9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57494.1
AE013599 Genomic DNA Translation: AAF57495.1
AE013599 Genomic DNA Translation: AAM68400.1
BT003200 mRNA Translation: AAO24955.1

NCBI Reference Sequences

More...
RefSeqi
NP_611463.1, NM_137619.3
NP_725941.1, NM_166381.2
NP_725942.1, NM_166382.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086270; FBpp0085582; FBgn0034491
FBtr0086271; FBpp0085583; FBgn0034491
FBtr0086272; FBpp0085584; FBgn0034491

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11055

UCSC genome browser

More...
UCSCi
CG11055-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57494.1
AE013599 Genomic DNA Translation: AAF57495.1
AE013599 Genomic DNA Translation: AAM68400.1
BT003200 mRNA Translation: AAO24955.1
RefSeqiNP_611463.1, NM_137619.3
NP_725941.1, NM_166381.2
NP_725942.1, NM_166382.2

3D structure databases

SMRiQ7JR83
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ7JR83, 3 interactors
STRINGi7227.FBpp0085582

Genome annotation databases

EnsemblMetazoaiFBtr0086270; FBpp0085582; FBgn0034491
FBtr0086271; FBpp0085583; FBgn0034491
FBtr0086272; FBpp0085584; FBgn0034491
GeneIDi37289
KEGGidme:Dmel_CG11055
UCSCiCG11055-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37289
FlyBaseiFBgn0034491 Hsl

Phylogenomic databases

eggNOGiKOG4388 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00730000111056
HOGENOMiCLU_010288_1_0_1
KOiK07188
OMAiFLAYCPT
OrthoDBi1263520at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
a fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37289

Gene expression databases

BgeeiFBgn0034491 Expressed in crop (Drosophila) and 30 other tissues

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR010468 HSL_N
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PF06350 HSL_N, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7JR83_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JR83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: February 26, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again