Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

LD16921p

Gene

tna

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LD16921pImported
Submitted name:
Tonalli, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tnaImported
Synonyms:02Imported, 0583Imported, anon-WO0118547.590Imported, Dmel\CG7958Imported, l(3)L6731Imported, l(3)rI075Imported, l(3)S058302Imported
ORF Names:CG7958Imported, Dmel_CG7958Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026160, tna

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0026160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026160, Expressed in embryo and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7JR52, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7JR52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini703 – 780SP-RING-typeInterPro annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni116 – 199DisorderedSequence analysisAdd BLAST84
Regioni282 – 312DisorderedSequence analysisAdd BLAST31
Regioni802 – 836DisorderedSequence analysisAdd BLAST35
Regioni884 – 1024DisorderedSequence analysisAdd BLAST141
Regioni1081 – 1109DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 84Polar residuesSequence analysisAdd BLAST84
Compositional biasi116 – 173Polar residuesSequence analysisAdd BLAST58
Compositional biasi289 – 310Polar residuesSequence analysisAdd BLAST22
Compositional biasi819 – 836Polar residuesSequence analysisAdd BLAST18
Compositional biasi884 – 906Polar residuesSequence analysisAdd BLAST23
Compositional biasi926 – 942Polar residuesSequence analysisAdd BLAST17
Compositional biasi955 – 1003Polar residuesSequence analysisAdd BLAST49
Compositional biasi1084 – 1103Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009461_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
273193at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004181, Znf_MIZ
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02891, zf-MIZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51044, ZF_SP_RING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7JR52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQQAGSSRA PATGGQISPP GATTVGVEQQ QHLQQQHQQQ YYNQQQQQQQ
60 70 80 90 100
QQYQQQHQRD NFLAYQQQQQ QQQQQQQQLQ RSGGGGGNFM LGNDLVGGDS
110 120 130 140 150
LRSLNNTFGP NSEFTSLGGA NSSASSSLSG LSSSSSQGYT GMVAASQQHQ
160 170 180 190 200
QQQPHHHQQQ QQQQQQQHMG SMDAMGGYSQ MGGGMHPGPN SGMMGNMNGQ
210 220 230 240 250
YMNGGSGQGG YNGAQGMGMG YGGGGSMGPQ RHHQMTPMNQ MQNMSMGPGV
260 270 280 290 300
GGSGGMGGGM NPLQQQAAQQ QMGGMNPMAK MQGMANGGYP QQAPPSLTQQ
310 320 330 340 350
QQQQQQRRMA PYPHPQMHMA QKRAAAGVGG AGGMYPGNPM QQQQAQMYGN
360 370 380 390 400
QQMHPGSGGG VPLPMQAGGA GNGYGRSGPM GVGNGGYGRM SAGNGMGPTG
410 420 430 440 450
GPVMGPMGPG GMTAGGMGPG PGCMSQQRFM PQGSGGGMPG VGYGGVGGAA
460 470 480 490 500
SHQGQFYPGS GQSAGMQQAG GMCPAGPGAV ATTGNPYQNQ GFQQNYQHSP
510 520 530 540 550
VPGNPTPPLT PACSVPYVSP NPDIKPPMDN SEEMRLTFPV RDGIILAPFR
560 570 580 590 600
LLHNLSVSNH VFHLKQNVYN TLMCRNDLEL QLKCFHQDDR QMNTNWPHTV
610 620 630 640 650
TVSANATPLN IERSEKNSTA LRPLYLKAVC QPGRNTLQLT ASSCCCSHLF
660 670 680 690 700
VLQLVHRPSV RQVLQTLHKR NLLPLEHSVQ KIKRNLSQPE ANAGPDATPQ
710 720 730 740 750
QQQQQGGGQQ CAKISLKCPI TKSRIRLPAR GHECKHVQCF DLEAYLMINS
760 770 780 790 800
ERGSWRCPEC SKSAITDTLE IDQYIWAILN TLGNSDVDEV IIDSSANWRA
810 820 830 840 850
LQHNGGMPNA PPPSNVPSNP SGGSGSNSGN GSVNPTLPVI KQELCDDIAK
860 870 880 890 900
VMSPGSTQLP TWDSAQAMSP YNMHDMNSIA SGNMMGNGGN TNQHGNRSSY
910 920 930 940 950
DGFSGNHSDG SGGLPGGDGG VNSLDQLNAM EKSLSDQMPH TPHTPGAASH
960 970 980 990 1000
PMTPGGPPSV SSSHNEPISG GTPNANGSGS ATNGSGNNNS STGHNSPQTP
1010 1020 1030 1040 1050
GTPSRMGGGM GGSGSADSQQ QQQEQLLNSL MSSQTQLKFS ESDLSAELQS
1060 1070 1080 1090 1100
FDAAAAAIND TAHDLNLLQD VDPMEILSYL DPQPDLNTPP SSGSSNNNAS

DDLLATLFD
Length:1,109
Mass (Da):116,490
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FD726183EE642AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7KUE4Q7KUE4_DROME
Tonalli, isoform B
tna 02, 0583, anon-WO0118547.590, Dmel\CG7958, l(3)L6731
1,149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9VTB8Q9VTB8_DROME
Tonalli, isoform A
tna 02, 0583, anon-WO0118547.590, Dmel\CG7958, l(3)L6731
1,135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6J3SHB9A0A6J3SHB9_DROME
Tonalli, isoform E
tna 02, 0583, anon-WO0118547.590, Dmel\CG7958, l(3)L6731
1,186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT003272 mRNA Translation: AAO25029.1
AE014296 Genomic DNA Translation: ACZ94684.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163413.1, NM_001169942.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0301658; FBpp0290872; FBgn0026160

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7958

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT003272 mRNA Translation: AAO25029.1
AE014296 Genomic DNA Translation: ACZ94684.1
RefSeqiNP_001163413.1, NM_001169942.2

3D structure databases

SMRiQ7JR52
ModBaseiSearch...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
39217

Genome annotation databases

EnsemblMetazoaiFBtr0301658; FBpp0290872; FBgn0026160
GeneIDi39217
KEGGidme:Dmel_CG7958

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39217
FlyBaseiFBgn0026160, tna
VEuPathDBiVectorBase:FBgn0026160

Phylogenomic databases

GeneTreeiENSGT01030000234539
HOGENOMiCLU_009461_0_0_1
OrthoDBi273193at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
39217, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
tna, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39217

Gene expression databases

BgeeiFBgn0026160, Expressed in embryo and 43 other tissues
ExpressionAtlasiQ7JR52, baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181, Znf_MIZ
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891, zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044, ZF_SP_RING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7JR52_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JR52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again