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UniProtKB - Q7JR49 (VAS1_DROME)
Protein
V-type proton ATPase subunit S1
Gene
VhaAC45
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles.
2 PublicationsGO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- regulation of cellular pH Source: GO_Central
- vacuolar proton-transporting V-type ATPase complex assembly Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-DME-77387, Insulin receptor recycling R-DME-917977, Transferrin endocytosis and recycling R-DME-983712, Ion channel transport |
Protein family/group databases
TCDBi | 8.A.107.1.3, the v-type atpase assembly factor, atp6ap1 (atp6ap1) family |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit S1CuratedAlternative name(s): Vacuolar H(+) ATPase AC45 accessory subunitImported |
Gene namesi | ORF Names:CG8029Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0262515, VhaAC45 |
VEuPathDBi | VectorBase:FBgn0262515 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting V-type ATPase complex Source: GO_Central
- vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 333 | LumenalCuratedAdd BLAST | 316 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 379 | CytoplasmicCuratedAdd BLAST | 25 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5015098718 | 18 – 379 | V-type proton ATPase subunit S1Sequence analysisAdd BLAST | 362 | |
PropeptideiPRO_0000454044 | 18 – ? | By similarity |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 225 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 282 ↔ 326 | By similarity | ||
Glycosylationi | 284 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q7JR49 |
PRIDEi | Q7JR49 |
PTM databases
GlyGeni | Q7JR49, 2 sites |
SwissPalmi | Q7JR49 |
Expressioni
Gene expression databases
Bgeei | FBgn0262515, Expressed in second segment of antenna (Drosophila) and 43 other tissues |
Interactioni
Subunit structurei
Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump (By similarity). May interact with ATP6AP2 (PubMed:29995586).
By similarity1 PublicationProtein-protein interaction databases
IntActi | Q7JR49, 1 interactor |
STRINGi | 7227.FBpp0087668 |
Structurei
3D structure databases
AlphaFoldDBi | Q7JR49 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the vacuolar ATPase subunit S1 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3868, Eukaryota |
GeneTreei | ENSGT00940000170675 |
HOGENOMi | CLU_039408_1_0_1 |
InParanoidi | Q7JR49 |
OMAi | QSCYAQL |
OrthoDBi | 1111170at2759 |
PhylomeDBi | Q7JR49 |
Family and domain databases
InterProi | View protein in InterPro IPR008388, Ac45_acc_su |
PANTHERi | PTHR12471, PTHR12471, 1 hit |
Pfami | View protein in Pfam PF05827, ATP-synt_S1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7JR49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLWKSLIALC VIGAAVAEQT PVFLWGANSV AKPSLKTVSQ VEFAEQLAAL
60 70 80 90 100
LEDHMVVAFE ENGLSSKDFL CSNSQAQSCY AQLQGVSPKT YYTSVENPSE
110 120 130 140 150
ALRSVAAKRE HNSIDASGKL TTPAKCAVGT ALFVTFEDAA ESREASLESH
160 170 180 190 200
DAAIAAISKQ FECKVAYLYL AAPSTAPVVQ RRTRRDTAAT TGGIMWKSTN
210 220 230 240 250
QFQIFYTALL YNGNPITVTD LKLTNSSSTK LSVVMDTSVA DKPITFDVVY
260 270 280 290 300
NGGYFSLSNL VYDNNNFRSS GVNAPTTFSY SCGNLTLESA AVNNMYNTLS
310 320 330 340 350
FKSLQLQAPF DGTYKEDFPF GDSWDCVGFV TPGILMGLFV VALLLVIMFV
360 370
GVCWMMDINT MDRFDDPKGK TITINAAAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58965.1 AE013599 Genomic DNA Translation: AAF58966.2 BT003279 mRNA Translation: AAO25036.1 |
RefSeqi | NP_610470.1, NM_136626.5 NP_724770.1, NM_165665.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0088587; FBpp0087668; FBgn0262515 FBtr0088588; FBpp0087669; FBgn0262515 |
GeneIDi | 35944 |
KEGGi | dme:Dmel_CG8029 |
UCSCi | CG8029-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF58965.1 AE013599 Genomic DNA Translation: AAF58966.2 BT003279 mRNA Translation: AAO25036.1 |
RefSeqi | NP_610470.1, NM_136626.5 NP_724770.1, NM_165665.2 |
3D structure databases
AlphaFoldDBi | Q7JR49 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q7JR49, 1 interactor |
STRINGi | 7227.FBpp0087668 |
Protein family/group databases
TCDBi | 8.A.107.1.3, the v-type atpase assembly factor, atp6ap1 (atp6ap1) family |
PTM databases
GlyGeni | Q7JR49, 2 sites |
SwissPalmi | Q7JR49 |
Proteomic databases
PaxDbi | Q7JR49 |
PRIDEi | Q7JR49 |
Protocols and materials databases
DNASUi | 35944 |
Genome annotation databases
EnsemblMetazoai | FBtr0088587; FBpp0087668; FBgn0262515 FBtr0088588; FBpp0087669; FBgn0262515 |
GeneIDi | 35944 |
KEGGi | dme:Dmel_CG8029 |
UCSCi | CG8029-RA, d. melanogaster |
Organism-specific databases
CTDi | 35944 |
FlyBasei | FBgn0262515, VhaAC45 |
VEuPathDBi | VectorBase:FBgn0262515 |
Phylogenomic databases
eggNOGi | KOG3868, Eukaryota |
GeneTreei | ENSGT00940000170675 |
HOGENOMi | CLU_039408_1_0_1 |
InParanoidi | Q7JR49 |
OMAi | QSCYAQL |
OrthoDBi | 1111170at2759 |
PhylomeDBi | Q7JR49 |
Enzyme and pathway databases
Reactomei | R-DME-77387, Insulin receptor recycling R-DME-917977, Transferrin endocytosis and recycling R-DME-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 35944, 0 hits in 3 CRISPR screens |
ChiTaRSi | VhaAC45, fly |
GenomeRNAii | 35944 |
PROi | PR:Q7JR49 |
Gene expression databases
Bgeei | FBgn0262515, Expressed in second segment of antenna (Drosophila) and 43 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008388, Ac45_acc_su |
PANTHERi | PTHR12471, PTHR12471, 1 hit |
Pfami | View protein in Pfam PF05827, ATP-synt_S1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VAS1_DROME | |
Accessioni | Q7JR49Primary (citable) accession number: Q7JR49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 31, 2019 |
Last sequence update: | October 3, 2006 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families