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Entry version 143 (29 Sep 2021)
Sequence version 1 (03 Oct 2006)
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Protein

RBR-type E3 ubiquitin transferase

Gene

CG12339

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.ARBA annotation EC:2.3.2.31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processUbl conjugation pathwayARBA annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RBR-type E3 ubiquitin transferaseARBA annotation (EC:2.3.2.31ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG12339Imported
Synonyms:AAF58756.2Imported, CG7621Imported, Dmel\CG33144Imported, lincRNA.281Imported
ORF Names:CG33144Imported, Dmel_CG33144Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0053144, CG33144

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0053144

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1048 – 1070HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7JR34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0053144, Expressed in digestive system element and 44 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7JR34, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0291679

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini775 – 1034RING-typeInterPro annotationAdd BLAST260
Domaini779 – 825RING-typeInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 51DisorderedSequence analysisAdd BLAST22
Regioni68 – 97DisorderedSequence analysisAdd BLAST30
Regioni171 – 246DisorderedSequence analysisAdd BLAST76
Regioni302 – 346DisorderedSequence analysisAdd BLAST45
Regioni434 – 497DisorderedSequence analysisAdd BLAST64
Regioni660 – 716DisorderedSequence analysisAdd BLAST57
Regioni896 – 918DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 233Polar residuesSequence analysisAdd BLAST16
Compositional biasi309 – 333Polar residuesSequence analysisAdd BLAST25
Compositional biasi660 – 708Polar residuesSequence analysisAdd BLAST49
Compositional biasi896 – 917Polar residuesSequence analysisAdd BLAST22

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1815, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009338_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
MRPPMAM

Database of Orthologous Groups

More...
OrthoDBi
469819at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7JR34

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11685, PTHR11685, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01485, IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00647, IBR, 2 hits
SM00184, RING, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7JR34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPPMAMPSM QASTGLQPTE VHPVQQLHLH ATPSNPSDIH QDRSPHNHNA
60 70 80 90 100
KLPPLELLVE NKISYSSYQQ HAKDLKHQSH NQNRSKRSSL SSPSSSEDCV
110 120 130 140 150
SAARANIFDD AAENFVINFP SESATSQHLL PLSETVPLLT HIEATVVDKQ
160 170 180 190 200
RSIRLNKNSA SLIFTKKELN QGTREHHHQH NNQQHQQQQR RPHHSSLYGV
210 220 230 240 250
GRKPTKHLPP TRGHHQRRSL PLSYNNNLVT TAPSAGGAGG PGGAAKLVPL
260 270 280 290 300
KQQHQHHGAG HTAPPTANVV VAGGAGAAAP SARKQLSYSW YAPVYSALEE
310 320 330 340 350
ELEQDSRDSS PIHNLANTKQ HQRSASQKAS TALHATPRHD RAHDSADAET
360 370 380 390 400
VALLDTQTRS KIIISSANGD AGGAGAGVGF GGGGGGGSGN GGVLAANGGG
410 420 430 440 450
DLESSLGLSG GGQLPRRRRI ENFLKSLVGL KASSGRGGGG GGNVGGGGAV
460 470 480 490 500
PDRERPASPE IRITRTPSEQ DVVLRDPSGR QLANGHGRGS LSISGSSSSL
510 520 530 540 550
NVVQQKIWHI MRREGSASSL HQEKSQSIVQ YTGLRKCETV LALTRQSQSH
560 570 580 590 600
GHVHGLSQSR SQGHSLAVHG SGIFSSGGVE QIRPLNRLRN SVSSINGVGT
610 620 630 640 650
CSRCSSLLSL AASGSRYSLS NGFAPRPTSA LNHLEAGWED DQRRAQEPHI
660 670 680 690 700
NVNAQIRLSG GATANSTSPS PPSNVTTATL HSSSANNLNQ EPQQSTSTPA
710 720 730 740 750
TTPTETPGSG ELGPFGTNHA YPLTVSSLLS MASANQAAQA CCVRDGIALK
760 770 780 790 800
RREMLASADV TPSVGTPATP TTAFKPFTCK LCLIDVEDVG EAMALQQCGC
810 820 830 840 850
QFCIECMRAY VEFEISEGAY EISCPDATCP AQGAISLPEI ANLTTTNLLK
860 870 880 890 900
KHHRYRLNRE IELDKTRTWC PRAGCETICT VGAAAQPGQS SVICQMDESP
910 920 930 940 950
STSQSYSPQQ EVAGNGSTGA AAGNGAPVLS VSVHCPSCKD EFCGLCKKAY
960 970 980 990 1000
HPNISCDEFG RRLIADGQDD IGIPFDNELI KCCPMCAVPI EKDEGCAQMM
1010 1020 1030 1040 1050
CKRCKHVFCW YCLASLDDDF LLRHYDKGPC KNKLGHSRAS VVWHRAQVIG
1060 1070 1080 1090 1100
IFAGFGILLL VASPLLLLAA PCIICCKCRG CTGSKIDEVD AELEEEVTAL

QG
Length:1,102
Mass (Da):117,016
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC9B2E3861A43F56
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58756.2
BT003306 mRNA Translation: AAO25066.1
AE013599 Genomic DNA Translation: ADV37151.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188904.1, NM_001201975.2
NP_788324.1, NM_176144.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088254; FBpp0087349; FBgn0053144
FBtr0302517; FBpp0291679; FBgn0053144

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36131

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33144

UCSC genome browser

More...
UCSCi
CG33144-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58756.2
BT003306 mRNA Translation: AAO25066.1
AE013599 Genomic DNA Translation: ADV37151.1
RefSeqiNP_001188904.1, NM_001201975.2
NP_788324.1, NM_176144.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7JR34, 7 interactors
STRINGi7227.FBpp0291679

Proteomic databases

PRIDEiQ7JR34

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
36131

Genome annotation databases

EnsemblMetazoaiFBtr0088254; FBpp0087349; FBgn0053144
FBtr0302517; FBpp0291679; FBgn0053144
GeneIDi36131
KEGGidme:Dmel_CG33144
UCSCiCG33144-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0053144, CG33144
VEuPathDBiVectorBase:FBgn0053144

Phylogenomic databases

eggNOGiKOG1815, Eukaryota
HOGENOMiCLU_009338_0_0_1
OMAiMRPPMAM
OrthoDBi469819at2759
PhylomeDBiQ7JR34

Enzyme and pathway databases

ReactomeiR-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36131, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CG33144, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36131

Protein Ontology

More...
PROi
PR:Q7JR34

Gene expression databases

BgeeiFBgn0053144, Expressed in digestive system element and 44 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127, E3_UB_ligase_RBR
IPR002867, IBR_dom
IPR044066, TRIAD_supradom
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR11685, PTHR11685, 2 hits
PfamiView protein in Pfam
PF01485, IBR, 2 hits
SMARTiView protein in SMART
SM00647, IBR, 2 hits
SM00184, RING, 2 hits
PROSITEiView protein in PROSITE
PS51873, TRIAD, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7JR34_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JR34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 29, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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