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Protein

Receptor-type guanylate cyclase Gyc76C

Gene

Gyc76C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin (PubMed:21893139). Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity (PubMed:15282266, PubMed:24284209). Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscles and for localization of integrin beta-ps at developing dorsal muscle myotendinous junctions (PubMed:23213443). Required for invagination, migration and lumen shape of the embryonic salivary gland by regulating the localization of the integrin-binding protein rhea/Talin to the visceral mesoderm surrounding the gland and maintaining the laminin matrix (PubMed:23862019). Required in the developing wing to regulate extracellular matrix (ECM) organization by activating the cGMP-dependent protein kinase For which represses the activity of matrix metalloproteases such as Mmp2 and decreases ECM matrix reorganization (PubMed:26440503).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei581ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi901Magnesium 1PROSITE-ProRule annotation1
Metal bindingi901Magnesium 2PROSITE-ProRule annotation1
Metal bindingi902Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi945Magnesium 1PROSITE-ProRule annotation1
Metal bindingi945Magnesium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi553 – 561ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • peptide receptor activity Source: FlyBase
  • semaphorin receptor binding Source: FlyBase
  • signaling receptor activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis
LigandATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type guanylate cyclase Gyc76CCurated (EC:4.6.1.2UniRule annotation1 Publication)
Alternative name(s):
DrGC-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gyc76CImported
ORF Names:CG42636Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0266136 Gyc76C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 493ExtracellularCuratedAdd BLAST474
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 1525CytoplasmicCuratedAdd BLAST1011

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abnormal patterning of the somatic body wall muscles with numerous ventral and lateral muscles that fail to extend or are missing and reduced levels of integrin beta-ps at dorsal muscle myotendinous junctions (PubMed:23213443). Defects in salivary gland invagination, migration and lumen shape and mislocalization of the integrin-binding protein rhea/Talin (PubMed:23862019). Defects in motor axon guidance with failure of motor axons to defasciculate from one another and innervate their proper muscle targets (PubMed:15282266). Wings display disrupted posterior crossveins (PubMed:26440503). RNAi-mediated knockdown in malpighian tubule principal cells inhibits NPLP1-4-mediated increases in fluid transport rates and cGMP levels, inhibits NPLP1-4-mediated nuclear translocation of NF-kappa-B protein Rel and abolishes expression of the antimicrobial peptide diptericin (PubMed:21893139).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi635L → H in 3L043; complete loss of the posterior crossvein in adult wings. 1 Publication1
Mutagenesisi945D → A: Abolishes guanylate cyclase activity but does not affect cell surface location. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500721316120 – 1525Receptor-type guanylate cyclase Gyc76CAdd BLAST1506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi184N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi222N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi338N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi383N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi394N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi416N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi428N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi458N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7JQ32

PRoteomics IDEntifications database

More...
PRIDEi
Q7JQ32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the adult, widely distributed in the head and thorax with highest levels in the optic lobe and central brain and expression also detected in the retina (PubMed:7759483). Expressed at similar levels in adult head and body (PubMed:7759483). In females, highly expressed in oocytes with lower levels in the digestive tract (PubMed:7759483). In mid-embryogenesis, enriched in the circular visceral mesoderm that overlies the migrating salivary gland and in the fat body that underlies the gland but at background levels in the gland itself (PubMed:23213443). In late embryogenesis, detected in the mature salivary gland, in the somatic body wall muscles and the tendon cells to which the muscles attach, and in the constricting midgut (PubMed:23213443). Also expressed in migrating tracheal cells at mid-embryogenesis and in the developed trachea at the end of embryogenesis with enrichment in the apical domains (PubMed:23213443).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo, larva, pupa and adult (PubMed:7706258, PubMed:7759483). Expressed at very high levels in early cleavage stage embryos at 0-2 hours followed by lower expression at 2-6 and 6-10 hours of embryogenesis (PubMed:7706258). During later stages of embryogenesis at 10-14 and 14-18 hours, expressed again at high levels, particularly in muscle fibers (PubMed:7706258). Very low levels in larval and pupal stages (PubMed:7706258).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261360 Expressed in 3 organ(s), highest expression level in larva

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the semaphorin 1A receptor PlexA; PlexA enhances Gyc76C catalytic activity. Interacts with the PDZ domain-containing protein kermit; kermit increases cell surface expression of Gyc76C.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q7JQ32, 8 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0291487

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7JQ32

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7JQ32

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini547 – 824Protein kinasePROSITE-ProRule annotationAdd BLAST278
Domaini896 – 1026Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The guanylate cyclase domain is required for Sema-1a-mediated axon repulsion.1 Publication
The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1023 Eukaryota
COG2114 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000168507

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7JQ32

KEGG Orthology (KO)

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KOi
K01769

Identification of Orthologs from Complete Genome Data

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OMAi
SIGEHQY

Database of Orthologous Groups

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OrthoDBi
EOG091G02QS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7JQ32

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00044 CYCc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7JQ32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRWPFNLLL LLSVAVRDCS NHRTVLTVGY LTALTGDLKT RQGLAISGAL
60 70 80 90 100
TMALDEVNKD PNLLPNVYLD LRWNDTKGDT VLATKAITEM ICDGIATIFG
110 120 130 140 150
PEGPCYVEAI VSQSRNIPMI SYKCAEYRAS AIPTFARTEP PDTQVVKSLL
160 170 180 190 200
ALLRYYAWNK FSILYEDVWS PVADLLKDQA TKRNMTINHK QSFIDNRVKC
210 220 230 240 250
CEQMLDCCRS GYWYQLVQNT MNRTRIYVFL GAANSLVDFM SSMETAGLFA
260 270 280 290 300
RGEYMVIFVD MMVYSEREAE KYLRRVDQIT FMSNCHSTEN FNQMARSLLV
310 320 330 340 350
VASTPPTKDY IQFTKQVQKY SSKPPFNLEI PRLFVESNFS KFISIYAAYL
360 370 380 390 400
YDSVKLYAWA VDKMLREETR VLTDDVIFEV ASNGTRVIDT IIKNRTYMSI
410 420 430 440 450
TGSKIKIDQY GDSEGNFSVL AYKPHKWNNS NNMPCNYHMV PVAYFHQGEE
460 470 480 490 500
HPEYKLINGS IDWPSGGEKP ADEPMCGFAN ELCKKDDTHY TSTVAAVVLG
510 520 530 540 550
VLLFCSGVIT MSIYRKWKIE LEIEGLLWKI DPNEIKGYSG NEIVSSPSKV
560 570 580 590 600
SLMSAQSYGS RWTNQFVTST GRLRGAVVRI KELKFPRKRD ISREIMKEMR
610 620 630 640 650
LLRELRHDNI NSFIGASVEP TRILLVTDYC AKGSLYDIIE NEDIKLDDLF
660 670 680 690 700
IASLIHDLIK GMIYIHNSQL VYHGNLKSSN CVVTSRWMLQ VTDFGLHELR
710 720 730 740 750
QCAENESIGE HQHYRNQLWR APELLRNHIH GSQKGDVYAF AIIMYEIFSR
760 770 780 790 800
KGPFGQINFE PKEIVDYVKK LPLKGEDPFR PEVESIIEAE SCPDYVLACI
810 820 830 840 850
RDCWAEDPEE RPEFSVIRNR LKKMRGGKTK NIMDQMMEMM EKYANNLEDI
860 870 880 890 900
VTERTRLLCE EKMKTEDLLH RMLPQSVAEK LTMGQGVEPV SYDLVTIYFS
910 920 930 940 950
DIVGFTAMSA ESTPLQVVNF LNDLYTVFDR IIRGYDVYKV ETIGDAYMVV
960 970 980 990 1000
SGLPIKNGDR HAGEIASMAL ELLHAVKQHR IAHRPNETLK LRIGMHTGPV
1010 1020 1030 1040 1050
VAGVVGLTMP RYCLFGDTVN TASRMESNGE ALKIHISNKC KLALDKLGGG
1060 1070 1080 1090 1100
YITEKRGLVN MKGKGDVVTW WLTGANENAI QKKLVDMMDM PPPLFSRPRK
1110 1120 1130 1140 1150
SPKLNPDSRQ PSIQAMHFCG TGSRRQSTVP RAMDGESTYS LQGSVRESPR
1160 1170 1180 1190 1200
MVSKRDRDRE RPPINGLGAG HFVGGALLES AQASLSTLNH SETNETNCDM
1210 1220 1230 1240 1250
DGGSGGVSGS GSGLVRQPNA LHKPLAMVRP HRIISAAQLP QLGDNDDDSA
1260 1270 1280 1290 1300
DTLLRESRSL DPMPMQQLRK RHDRVKLPPS KLSKNNSRSL DTGVSLISGN
1310 1320 1330 1340 1350
PNGEVHSSQL DLDNEMTANP VDATDGYDDE LGLLMRHDNG QLPALRYSGS
1360 1370 1380 1390 1400
FPNAQISIVP TGRSAGGGGG GREGGGSNCA KHLNNNCNGG VNVEDDLESP
1410 1420 1430 1440 1450
LLQRQASLSV PPEEMLAHNK RWHSLEHMDG PGGHGGNSVS YAADIDNRHP
1460 1470 1480 1490 1500
GDLDFFSGSS NQHHRSKAAG GSKLTNWMTN IFKGNGVRSG EARRVGILPS
1510 1520
GVHGARTGFT DMAASAAARD RESIV
Length:1,525
Mass (Da):170,503
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5055D253FD398D30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V243A4V243_DROME
Guanylate cyclase
Dmel\CG42637 CG42637, Dmel_CG42637
1,525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti381A → S in AAA85858 (PubMed:7759483).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L35598 mRNA Translation: AAA74408.1
U23485 mRNA Translation: AAA85858.1
AE014296 Genomic DNA Translation: ACZ94744.1
AE014296 Genomic DNA Translation: ACZ94745.1
AE014296 Genomic DNA Translation: ACZ94746.1
AE014296 Genomic DNA Translation: AGB94756.1
BT011062 mRNA Translation: AAR31133.1

Protein sequence database of the Protein Information Resource

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PIRi
A56699

NCBI Reference Sequences

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RefSeqi
NP_001007096.1, NM_001007095.3
NP_001007097.1, NM_001007096.3
NP_001163473.1, NM_001170002.1
NP_001163474.1, NM_001170003.2
NP_001163475.1, NM_001170004.2
NP_001262063.1, NM_001275134.1
NP_524165.2, NM_079441.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.2520

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0302277; FBpp0291483; FBgn0261360
FBtr0302278; FBpp0291484; FBgn0261360
FBtr0302279; FBpp0291485; FBgn0261360
FBtr0302280; FBpp0291486; FBgn0266136
FBtr0302281; FBpp0291487; FBgn0266136
FBtr0302282; FBpp0291488; FBgn0266136
FBtr0333879; FBpp0306011; FBgn0266136

Database of genes from NCBI RefSeq genomes

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GeneIDi
40153
8674026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG42636
dme:Dmel_CG42637

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35598 mRNA Translation: AAA74408.1
U23485 mRNA Translation: AAA85858.1
AE014296 Genomic DNA Translation: ACZ94744.1
AE014296 Genomic DNA Translation: ACZ94745.1
AE014296 Genomic DNA Translation: ACZ94746.1
AE014296 Genomic DNA Translation: AGB94756.1
BT011062 mRNA Translation: AAR31133.1
PIRiA56699
RefSeqiNP_001007096.1, NM_001007095.3
NP_001007097.1, NM_001007096.3
NP_001163473.1, NM_001170002.1
NP_001163474.1, NM_001170003.2
NP_001163475.1, NM_001170004.2
NP_001262063.1, NM_001275134.1
NP_524165.2, NM_079441.4
UniGeneiDm.2520

3D structure databases

ProteinModelPortaliQ7JQ32
SMRiQ7JQ32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7JQ32, 8 interactors
STRINGi7227.FBpp0291487

Proteomic databases

PaxDbiQ7JQ32
PRIDEiQ7JQ32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0302277; FBpp0291483; FBgn0261360
FBtr0302278; FBpp0291484; FBgn0261360
FBtr0302279; FBpp0291485; FBgn0261360
FBtr0302280; FBpp0291486; FBgn0266136
FBtr0302281; FBpp0291487; FBgn0266136
FBtr0302282; FBpp0291488; FBgn0266136
FBtr0333879; FBpp0306011; FBgn0266136
GeneIDi40153
8674026
KEGGidme:Dmel_CG42636
dme:Dmel_CG42637

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8674026
FlyBaseiFBgn0266136 Gyc76C

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000168507
InParanoidiQ7JQ32
KOiK01769
OMAiSIGEHQY
OrthoDBiEOG091G02QS
PhylomeDBiQ7JQ32

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Gyc76C fly

Protein Ontology

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PROi
PR:Q7JQ32

Gene expression databases

BgeeiFBgn0261360 Expressed in 3 organ(s), highest expression level in larva

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGC76C_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JQ32
Secondary accession number(s): Q24051
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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