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Protein

Transporter

Gene

SLC6A3

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:SLC6A3Imported
ORF Names:EGK_06774Imported
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 87HelicalSequence analysisAdd BLAST19
Transmembranei99 – 120HelicalSequence analysisAdd BLAST22
Transmembranei141 – 168HelicalSequence analysisAdd BLAST28
Transmembranei238 – 255HelicalSequence analysisAdd BLAST18
Transmembranei267 – 291HelicalSequence analysisAdd BLAST25
Transmembranei311 – 332HelicalSequence analysisAdd BLAST22
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei392 – 418HelicalSequence analysisAdd BLAST27
Transmembranei447 – 472HelicalSequence analysisAdd BLAST26
Transmembranei478 – 501HelicalSequence analysisAdd BLAST24
Transmembranei522 – 544HelicalSequence analysisAdd BLAST23
Transmembranei556 – 578HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6197

Expressioni

Gene expression databases

BgeeiENSMMUG00000005198 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000006879

Structurei

3D structure databases

SMRiQ7JHP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
HOVERGENiHBG071421
OMAiGMATFIF
OrthoDBiEOG091G08PX
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002436 Na/ntran_symport_dopamine
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01202 DOPTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7JHP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSKCSVGL MSSVVAPAKE PNAMGPKEVE LILVKEQNGV QLTSSTLTNP
60 70 80 90 100
RQSPVEAQDR ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV
110 120 130 140 150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPVLKG VGFTVILISL
160 170 180 190 200
YVGFFYNVII AWALHYLFSS FTTELPWIHC NNSWNSPNCS DAHSGDSGGN
210 220 230 240 250
GPGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL TACLVLVIVL
260 270 280 290 300
LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV
310 320 330 340 350
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT
360 370 380 390 400
SINSLTSFSS GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT
410 420 430 440 450
LPLSSAWAVV FFIMLLTLGI DSAMGGMESV ITGLIDEFQL LHRHRELFTL
460 470 480 490 500
FIVLATFLLS LFCVTNGGIY VFTLLDHFAA GTSILFGVLI EAIGVAWFYG
510 520 530 540 550
VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI VTFRPPHYGA
560 570 580 590 600
YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD
610 620
RELVDRGEVR QFTLRHWLKV
Length:620
Mass (Da):68,452
Last modified:July 5, 2004 - v1
Checksum:i5A9B9379DFEDF0FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286445 mRNA Translation: AAG00536.1
EF174602 mRNA Translation: ABO77643.1
CM001266 Genomic DNA Translation: EHH23326.1
RefSeqiXP_014995184.1, XM_015139698.1
UniGeneiMmu.3403

Genome annotation databases

GeneIDi574143

Similar proteinsi

Entry informationi

Entry nameiQ7JHP9_MACMU
AccessioniPrimary (citable) accession number: Q7JHP9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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