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Entry version 128 (11 Dec 2019)
Sequence version 2 (07 Mar 2006)
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Protein

ABC transporter C family member 5

Gene

ABCC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pump for glutathione S-conjugates. Involved in regulation of K+ and Na+ cell content. Mediates resistance to NaCl and Li+, confers sensitivity to sulfonylurea drugs such as glibenclamide (inducer of stomatal opening), and required for stomatal opening regulation by auxin, abscisic acid (ABA) and external Ca2+. Transports oestradiol-17-(beta-D-glucuronide) (E217G). Involved in the root auxin content regulation that controls the transition from primary root elongation to lateral root formation. Plays a role in ABA-mediated germination inhibition (PubMed:11296221, PubMed:11855639, PubMed:12943546, PubMed:14684837). High-affinity inositol hexakisphosphate transporter that plays a role in guard cell signaling and phytic acid storage. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds (PubMed:19797057).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2). EC:7.6.2.2

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

(E217G) transport activity in negatively regulated by organic anions such as oestradiol-3-sulfate, luteolin-7-O-diglucuronide-4'-O-glucuronide, glycocholate, vanadate and the sulfonylurea glibenclamide, and, to a lower extent, by bafilomycin A1, NH4Cl, GSH, GSSG and DNB-GS.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi657 – 664ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1302 – 1309ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT1G04120-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.21 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter C family member 5 (EC:7.6.2.2)
Short name:
ABC transporter ABCC.5
Short name:
AtABCC5
Alternative name(s):
ATP-energized glutathione S-conjugate pump 5
Glutathione S-conjugate-transporting ATPase 5
Multidrug resistance-associated protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC5
Synonyms:MRP5
Ordered Locus Names:At1g04120
ORF Names:F20D22.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G04120

The Arabidopsis Information Resource

More...
TAIRi
locus:2020235 AT1G04120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei76 – 96HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei111 – 131HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei177 – 197HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei312 – 332HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei334 – 354HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei421 – 441HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei446 – 466HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei533 – 553HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei946 – 966HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei986 – 1006HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1078 – 1098HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1117 – 1137HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1155 – 1175HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1180 – 1200HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increase water use efficiency (PubMed:12943546). Low phytic acid levels in seed tissue (PubMed:19797057).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002260761 – 1514ABC transporter C family member 5Add BLAST1514

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7GB25

PRoteomics IDEntifications database

More...
PRIDEi
Q7GB25

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7GB25

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, mostly in vascular tissues and epidermis, including guard cells.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In flowers, present in anthers central vascular strand of the filament and in connecting tissues of the pollen sacs. Also present at the silique attachment site of the pedicel.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7GB25 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7GB25 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
24512, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q7GB25, 7 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G04120.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7GB25

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini307 – 588ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST282
Domaini622 – 845ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini949 – 1231ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
Domaini1268 – 1502ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili899 – 927Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7GB25

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7GB25

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7GB25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFIEISLIF REHLPLLELC SVIINLLLFL VFLFAVSARQ ILVCVRRGRD
60 70 80 90 100
RLSKDDTVSA SNLSLEREVN HVSVGFGFNL SLLCCLYVLG VQVLVLVYDG
110 120 130 140 150
VKVRREVSDW FVLCFPASQS LAWFVLSFLV LHLKYKSSEK LPFLVRIWWF
160 170 180 190 200
LAFSICLCTM YVDGRRLAIE GWSRCSSHVV ANLAVTPALG FLCFLAWRGV
210 220 230 240 250
SGIQVTRSSS DLQEPLLVEE EAACLKVTPY STAGLVSLIT LSWLDPLLSA
260 270 280 290 300
GSKRPLELKD IPLLAPRDRA KSSYKVLKSN WKRCKSENPS KPPSLARAIM
310 320 330 340 350
KSFWKEAACN AVFAGLNTLV SYVGPYLISY FVDYLGGKEI FPHEGYVLAG
360 370 380 390 400
IFFTSKLIET VTTRQWYMGV DILGMHVRSA LTAMVYRKGL KLSSIAKQNH
410 420 430 440 450
TSGEIVNYMA VDVQRIGDYS WYLHDIWMLP MQIVLALAIL YKSVGIAAVA
460 470 480 490 500
TLVATIISIL VTIPLAKVQE DYQDKLMTAK DERMRKTSEC LRNMRVLKLQ
510 520 530 540 550
AWEDRYRVRL EEMREEEYGW LRKALYSQAF VTFIFWSSPI FVAAVTFATS
560 570 580 590 600
IFLGTQLTAG GVLSALATFR ILQEPLRNFP DLVSMMAQTK VSLDRISGFL
610 620 630 640 650
QEEELQEDAT VVIPRGLSNI AIEIKDGVFC WDPFSSRPTL SGIQMKVEKG
660 670 680 690 700
MRVAVCGTVG SGKSSFISCI LGEIPKISGE VRICGTTGYV SQSAWIQSGN
710 720 730 740 750
IEENILFGSP MEKTKYKNVI QACSLKKDIE LFSHGDQTII GERGINLSGG
760 770 780 790 800
QKQRVQLARA LYQDADIYLL DDPFSALDAH TGSDLFRDYI LSALAEKTVV
810 820 830 840 850
FVTHQVEFLP AADLILVLKE GRIIQSGKYD DLLQAGTDFK ALVSAHHEAI
860 870 880 890 900
EAMDIPSPSS EDSDENPIRD SLVLHNPKSD VFENDIETLA KEVQEGGSAS
910 920 930 940 950
DLKAIKEKKK KAKRSRKKQL VQEEERVKGK VSMKVYLSYM GAAYKGALIP
960 970 980 990 1000
LIILAQAAFQ FLQIASNWWM AWANPQTEGD ESKVDPTLLL IVYTALAFGS
1010 1020 1030 1040 1050
SVFIFVRAAL VATFGLAAAQ KLFLNMLRSV FRAPMSFFDS TPAGRILNRV
1060 1070 1080 1090 1100
SIDQSVVDLD IPFRLGGFAS TTIQLCGIVA VMTNVTWQVF LLVVPVAVAC
1110 1120 1130 1140 1150
FWMQKYYMAS SRELVRIVSI QKSPIIHLFG ESIAGAATIR GFGQEKRFIK
1160 1170 1180 1190 1200
RNLYLLDCFV RPFFCSIAAI EWLCLRMELL STLVFAFCMV LLVSFPHGTI
1210 1220 1230 1240 1250
DPSMAGLAVT YGLNLNGRLS RWILSFCKLE NKIISIERIY QYSQIVGEAP
1260 1270 1280 1290 1300
AIIEDFRPPS SWPATGTIEL VDVKVRYAEN LPTVLHGVSC VFPGGKKIGI
1310 1320 1330 1340 1350
VGRTGSGKST LIQALFRLIE PTAGKITIDN IDISQIGLHD LRSRLGIIPQ
1360 1370 1380 1390 1400
DPTLFEGTIR ANLDPLEEHS DDKIWEALDK SQLGDVVRGK DLKLDSPVLE
1410 1420 1430 1440 1450
NGDNWSVGQR QLVSLGRALL KQAKILVLDE ATASVDTATD NLIQKIIRTE
1460 1470 1480 1490 1500
FEDCTVCTIA HRIPTVIDSD LVLVLSDGRV AEFDTPARLL EDKSSMFLKL
1510
VTEYSSRSTG IPEL
Length:1,514
Mass (Da):168,574
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35351F361D101783
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4I454F4I454_ARATH
Multidrug resistance-associated pro...
ABCC5 ATABCC5, ATMRP5, ATP-binding cassette C5, MULTIDRUG RESISTANCE PROTEIN 5, At1g04120
1,509Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8AT08A0A1P8AT08_ARATH
Multidrug resistance-associated pro...
ABCC5 ATABCC5, ATMRP5, ATP-binding cassette C5, MULTIDRUG RESISTANCE PROTEIN 5, At1g04120
1,479Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC16754 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y11250 mRNA Translation: CAA72120.1
AF225908 mRNA Translation: AAG14965.1
AC002411 Genomic DNA Translation: AAC16754.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27658.1
AK220840 mRNA Translation: BAD94167.1

Protein sequence database of the Protein Information Resource

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PIRi
T00961
T52080

NCBI Reference Sequences

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RefSeqi
NP_171908.1, NM_100293.3 [Q7GB25-1]

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G04120.1; AT1G04120.1; AT1G04120 [Q7GB25-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
839277

Gramene; a comparative resource for plants

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Gramenei
AT1G04120.1; AT1G04120.1; AT1G04120 [Q7GB25-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G04120

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11250 mRNA Translation: CAA72120.1
AF225908 mRNA Translation: AAG14965.1
AC002411 Genomic DNA Translation: AAC16754.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27658.1
AK220840 mRNA Translation: BAD94167.1
PIRiT00961
T52080
RefSeqiNP_171908.1, NM_100293.3 [Q7GB25-1]

3D structure databases

SMRiQ7GB25
ModBaseiSearch...

Protein-protein interaction databases

BioGridi24512, 7 interactors
IntActiQ7GB25, 7 interactors
STRINGi3702.AT1G04120.1

Protein family/group databases

TCDBi3.A.1.208.21 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ7GB25

Proteomic databases

PaxDbiQ7GB25
PRIDEiQ7GB25

Genome annotation databases

EnsemblPlantsiAT1G04120.1; AT1G04120.1; AT1G04120 [Q7GB25-1]
GeneIDi839277
GrameneiAT1G04120.1; AT1G04120.1; AT1G04120 [Q7GB25-1]
KEGGiath:AT1G04120

Organism-specific databases

AraportiAT1G04120
TAIRilocus:2020235 AT1G04120

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ7GB25
OrthoDBi138195at2759
PhylomeDBiQ7GB25

Enzyme and pathway databases

BioCyciARA:AT1G04120-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7GB25

Gene expression databases

ExpressionAtlasiQ7GB25 baseline and differential
GenevisibleiQ7GB25 AT

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB5C_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7GB25
Secondary accession number(s): O65619, Q56ZX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: December 11, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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