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Entry version 123 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Peroxiredoxin-2A

Gene

PRXIIA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (By similarity). May be involved in intracellular redox signaling (Probable).By similarity1 Publication

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation and subsequent reduction by glutaredoxin (Grx), or by thioredoxin (Trx).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei51Cysteine sulfenic acid (-SOH) intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntioxidant, Oxidoreductase, Peroxidase
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT1G65990-MONOMER

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
4352, AtPrxII01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxiredoxin-2A (EC:1.11.1.25By similarity)
Alternative name(s):
Glutaredoxin-dependent peroxiredoxinCurated
Peroxiredoxin IIA
Thioredoxin peroxidase 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRXIIA
Ordered Locus Names:At1g65990
ORF Names:F12P19.16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G65990

The Arabidopsis Information Resource

More...
TAIRi
locus:2009734, AT1G65990

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002822781 – 553Peroxiredoxin-2AAdd BLAST553

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7G959

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
226338

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7G959, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7G959, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G65990.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7G959

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 160ThioredoxinPROSITE-ProRule annotationAdd BLAST157
Domaini156 – 201F-boxPROSITE-ProRule annotationAdd BLAST46

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxiredoxin family. Prx5 subfamily.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0541, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034692_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7G959

KEGG Orthology (KO)

More...
KOi
K24140

Identification of Orthologs from Complete Genome Data

More...
OMAi
VERNEYA

Database of Orthologous Groups

More...
OrthoDBi
1281610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7G959

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03013, PRX5_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006527, F-box-assoc_dom_typ1
IPR017451, F-box-assoc_interact_dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR011043, Gal_Oxase/kelch_b-propeller
IPR037944, PRX5-like
IPR013740, Redoxin
IPR036249, Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646, F-box, 1 hit
PF07734, FBA_1, 1 hit
PF08534, Redoxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00256, FBOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50965, SSF50965, 1 hit
SSF52833, SSF52833, 1 hit
SSF81383, SSF81383, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01640, F_box_assoc_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181, FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7G959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPIDVGDFV PDGSISFFDD DDQLQTVSVH SLAAGKKVIL FGVPGAFPPT
60 70 80 90 100
CSMNHVNGFI EKAEELKSNG VDEIICLSGD DPFMITACSE NKHVKFVEDG
110 120 130 140 150
SGEYIQLLGL ELEVKDKGLG VRSRGFALLL DNLKVIVVNV GSGGDCSLFQ
160 170 180 190 200
LMKMTTTTMS NLPTDLLEEI ISRVPRKYMR AVRLTCKRWN GMFKSQSFTK
210 220 230 240 250
MHIGKEEAAT RELRQTRMIV MMDYNVYLMG IAVNEIPSIE TLGKLTCLDD
260 270 280 290 300
SEQVKISQVF CCEGLLLCIL KDDDTKIVVW NPYLGQTRWI QTRLICCVSG
310 320 330 340 350
WKKYALGYGN NSENRSCRSP KILRVTDNFN IFSENIPLQY EIYDFDSDVW
360 370 380 390 400
TTLDVSPHWF IMSERGLSLK GNTYWGAKER HAYGSIDHII CFDFTRERFG
410 420 430 440 450
PLLPLPFSAW GAQFASLSSV REDKITALFQ NCRAYKLELW ITTKIDVNNA
460 470 480 490 500
TWSKFFTMDT PYLHEILSLK TFFIDEENKI VVVSNKERDT KGDLTHDSID
510 520 530 540 550
IINGEARCLW KLGLGKPADK NCWPLVCPYV PSVVQIKQHK GGKTKEQSDY

KRH
Length:553
Mass (Da):62,654
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F53BBC2D3184E16
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009513 Genomic DNA Translation: AAF06060.1
CP002684 Genomic DNA Translation: AEE34450.1
DQ056510 mRNA Translation: AAY78667.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D96684

NCBI Reference Sequences

More...
RefSeqi
NP_176774.1, NM_105271.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G65990.1; AT1G65990.1; AT1G65990

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
842912

Gramene; a comparative resource for plants

More...
Gramenei
AT1G65990.1; AT1G65990.1; AT1G65990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G65990

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009513 Genomic DNA Translation: AAF06060.1
CP002684 Genomic DNA Translation: AEE34450.1
DQ056510 mRNA Translation: AAY78667.1
PIRiD96684
RefSeqiNP_176774.1, NM_105271.1

3D structure databases

SMRiQ7G959
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G65990.1

Protein family/group databases

PeroxiBasei4352, AtPrxII01

Proteomic databases

PaxDbiQ7G959
ProteomicsDBi226338

Genome annotation databases

EnsemblPlantsiAT1G65990.1; AT1G65990.1; AT1G65990
GeneIDi842912
GrameneiAT1G65990.1; AT1G65990.1; AT1G65990
KEGGiath:AT1G65990

Organism-specific databases

AraportiAT1G65990
TAIRilocus:2009734, AT1G65990

Phylogenomic databases

eggNOGiKOG0541, Eukaryota
HOGENOMiCLU_034692_0_0_1
InParanoidiQ7G959
KOiK24140
OMAiVERNEYA
OrthoDBi1281610at2759
PhylomeDBiQ7G959

Enzyme and pathway databases

BioCyciARA:AT1G65990-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7G959

Gene expression databases

ExpressionAtlasiQ7G959, baseline and differential
GenevisibleiQ7G959, AT

Family and domain databases

CDDicd03013, PRX5_like, 1 hit
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR006527, F-box-assoc_dom_typ1
IPR017451, F-box-assoc_interact_dom
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR011043, Gal_Oxase/kelch_b-propeller
IPR037944, PRX5-like
IPR013740, Redoxin
IPR036249, Thioredoxin-like_sf
PfamiView protein in Pfam
PF00646, F-box, 1 hit
PF07734, FBA_1, 1 hit
PF08534, Redoxin, 1 hit
SMARTiView protein in SMART
SM00256, FBOX, 1 hit
SUPFAMiSSF50965, SSF50965, 1 hit
SSF52833, SSF52833, 1 hit
SSF81383, SSF81383, 1 hit
TIGRFAMsiTIGR01640, F_box_assoc_1, 1 hit
PROSITEiView protein in PROSITE
PS50181, FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRX2A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7G959
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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