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Protein

Dihydropteroate synthase

Gene

sulII

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP), Dihydropteroate synthase (sulII), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (sul1), Dihydropteroate synthase (B7947_10805), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processFolate biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthaseUniRule annotation (EC:2.5.1.15UniRule annotation)
Short name:
DHPSUniRule annotation
Alternative name(s):
Dihydropteroate pyrophosphorylaseUniRule annotation
Gene namesi
Name:sulIIImported
Synonyms:folPImported, sul2Imported
ORF Names:EN12_02905Imported, VC1786ICE_13Imported, Vcrx029Imported
Encoded oniPlasmid pVC1447Imported
Plasmid pVCR94deltaXImported
OrganismiVibrio choleraeImported
Taxonomic identifieri666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000036184 Componenti: Chromosome 1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 259Pterin-bindingInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the DHPS family.UniRule annotation

Phylogenomic databases

KOiK18824

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q7DFV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSLIIFGI VNITSDSFSD GGRYLAPDAA IAQARKLMAE GADVIDLGPA
60 70 80 90 100
SSNPDAAPVS SDTEIARIAP VLDALKADGI PVSLDSYQPA TQAYALSRGV
110 120 130 140 150
AYLNDIRGFP DAAFYPQLAK SSAKLVVMHS VQDGQADRRE APAGDIMDHI
160 170 180 190 200
AAFFDARIAA LTGAGIKRNR LVLDPGMGFF LGAAPETSLS VLARFDELRL
210 220 230 240 250
RFDLPVLLSV SRKSFLRALT GRGPGDVGAA TLAAELAAAA GGADFIRTHE
260 270
PRPLRDGLAV LAALKETARI R
Length:271
Mass (Da):28,470
Last modified:July 5, 2004 - v1
Checksum:i4B00E71A3F7970FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034138 Genomic DNA Translation: AAK64592.1
AY055428 Genomic DNA Translation: AAL59753.1
JN648379 Genomic DNA Translation: AEU11386.1
KF551948 Genomic DNA Translation: AHC56386.1
KC886257 Genomic DNA Translation: AHM25058.1
KM083064 Genomic DNA Translation: AIW55726.1
CP007653 Genomic DNA Translation: AKO74201.1
KT151654 Genomic DNA Translation: ALP44376.1
KT151655 Genomic DNA Translation: ALP44463.1
KT151656 Genomic DNA Translation: ALP44557.1
KT151657 Genomic DNA Translation: ALP44643.1
KT151658 Genomic DNA Translation: ALP44735.1
KT151659 Genomic DNA Translation: ALP44828.1
KT151660 Genomic DNA Translation: ALP44928.1
KT151661 Genomic DNA Translation: ALP45012.1
KT151662 Genomic DNA Translation: ALP45099.1
KT151663 Genomic DNA Translation: ALP45209.1
KT151664 Genomic DNA Translation: ALP45309.1
AB114188 Genomic DNA Translation: BAC79069.1
CGII01000180 Genomic DNA Translation: CPR29426.1
CGIJ01000180 Genomic DNA Translation: CPR29428.1
RefSeqiWP_001043260.1, NZ_PYBQ01000046.1
YP_008997665.1, NC_023291.1

Genome annotation databases

EnsemblBacteriaiAKO74201; AKO74201; EN12_02905
GeneIDi18156529
34760448
KEGGivcq:EN18_05275
vcq:EN18_06335
vcq:EN18_06385
PATRICifig|666.1969.peg.3723

Similar proteinsi

Entry informationi

Entry nameiQ7DFV9_VIBCL
AccessioniPrimary (citable) accession number: Q7DFV9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

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