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Entry version 102 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Translocated intimin receptor Tir

Gene

tir

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion. In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner. Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocated intimin receptor Tir
Alternative name(s):
Secreted effector protein Tir
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tir
Synonyms:espE
Ordered Locus Names:Z5112, ECs4561
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 230CytoplasmicSequence analysisAdd BLAST230
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 362ExtracellularSequence analysisAdd BLAST111
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 558CytoplasmicSequence analysisAdd BLAST175

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants show reduced bacterial adherence to host cells, and a loss of actin condensation beneath bacteria.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi452G → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi453T → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi454V → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi455Q → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi456N → A: Strong decrease in pedestal formation. Does not affect translocation into the host cell and ability to bind intimin. 1 Publication1
Mutagenesisi457P → A: Strong decrease in pedestal formation. Does not affect translocation into the host cell and ability to bind intimin. 1 Publication1
Mutagenesisi458Y → A: Strong decrease in pedestal formation. Does not affect translocation into the host cell and ability to bind intimin. 1 Publication1
Mutagenesisi458Y → F: Slight decrease in pedestal formation. Does not affect translocation into the host cell and ability to bind intimin. 1 Publication1
Mutagenesisi459A → G: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi460D → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi461V → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi462K → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1
Mutagenesisi463T → A: Does not affect translocation into the host cell, ability to bind intimin and pedestal formation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004140511 – 558Translocated intimin receptor TirAdd BLAST558

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by host kinases.1 Publication

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with intimin.

Interacts with host BAIAP2 and BAIAP2L1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7DB77, 15 interactors

STRING: functional protein association networks

More...
STRINGi
155864.EDL933_4949

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1558
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7DB77

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7DB77

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni182 – 226DisorderedSequence analysisAdd BLAST45
Regioni257 – 280DisorderedSequence analysisAdd BLAST24
Regioni388 – 451DisorderedSequence analysisAdd BLAST64
Regioni533 – 558DisorderedSequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi456 – 458Essential for actin pedestal formation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 44Polar residuesSequence analysisAdd BLAST15
Compositional biasi206 – 226Polar residuesSequence analysisAdd BLAST21
Compositional biasi258 – 280Polar residuesSequence analysisAdd BLAST23
Compositional biasi537 – 552Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The intracellular N-terminal region contributes to the initiation of actin assembly and influences pedestal length. The central extracellular region is involved in bacterial intimin binding. The intracellular C-terminal region is required for initiation of actin pedestal formation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tir receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG5033PQE, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_497576_0_0_6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.820.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037003, Tir_central_sf
IPR022638, Transloc_intimin_rcpt
IPR022639, Transloc_intimin_rcpt_C
IPR003536, Transloc_intimin_rcpt_cen_dom
IPR022633, Transloc_intimin_rcpt_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07489, Tir_receptor_C, 1 hit
PF03549, Tir_receptor_M, 1 hit
PF07490, Tir_receptor_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01370, TRNSINTIMINR

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7DB77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIGNLGHNP NVNNSIPPAP PLPSQTDGAG GRGQLINSTG PLGSRALFTP
60 70 80 90 100
VRNSMADSGD NRASDVPGLP VNPMRLAASE ITLNDGFEVL HDHGPLDTLN
110 120 130 140 150
RQIGSSVFRV ETQEDGKHIA VGQRNGVETS VVLSDQEYAR LQSIDPEGKD
160 170 180 190 200
KFVFTGGRGG AGHAMVTVAS DITEARQRIL ELLEPKGTGE SKGAGESKGV
210 220 230 240 250
GELRESNSGA ENTTETQTST STSSLRSDPK LWLALGTVAT GLIGLAATGI
260 270 280 290 300
VQALALTPEP DSPTTTDPDA AASATETATR DQLTKEAFQN PDNQKVNIDE
310 320 330 340 350
LGNAIPSGVL KDDVVANIEE QAKAAGEEAK QQAIENNAQA QKKYDEQQAK
360 370 380 390 400
RQEELKVSSG AGYGLSGALI LGGGIGVAVT AALHRKNQPV EQTTTTTTTT
410 420 430 440 450
TTTSARTVEN KPANNTPAQG NVDTPGSEDT MESRRSSMAS TSSTFFDTSS
460 470 480 490 500
IGTVQNPYAD VKTSLHDSQV PTSNSNTSVQ NMGNTDSVVY STIQHPPRDT
510 520 530 540 550
TDNGARLLGN PSAGIQSTYA RLALSGGLRH DMGGLTGGSN SAVNTSNNPP

APGSHRFV
Length:558
Mass (Da):58,022
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99C417222D4B4AA1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF071034 Genomic DNA Translation: AAC31506.1
AF125993 Genomic DNA Translation: AAD29391.1
GQ338312 Genomic DNA Translation: ACU09451.1
AE005174 Genomic DNA Translation: AAG58825.1
BA000007 Genomic DNA Translation: BAB37984.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A98199
E86045

NCBI Reference Sequences

More...
RefSeqi
NP_312588.1, NC_002695.1
WP_001301454.1, NZ_SWKA01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG58825; AAG58825; Z5112
BAB37984; BAB37984; ECs_4561

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
915465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ece:Z5112
ecs:ECs4561

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|386585.9.peg.4778

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071034 Genomic DNA Translation: AAC31506.1
AF125993 Genomic DNA Translation: AAD29391.1
GQ338312 Genomic DNA Translation: ACU09451.1
AE005174 Genomic DNA Translation: AAG58825.1
BA000007 Genomic DNA Translation: BAB37984.1
PIRiA98199
E86045
RefSeqiNP_312588.1, NC_002695.1
WP_001301454.1, NZ_SWKA01000005.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZQKX-ray2.80C/D/M/N269-336[»]
2ZWKX-ray3.10B/D/F274-336[»]
SMRiQ7DB77
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ7DB77, 15 interactors
STRINGi155864.EDL933_4949

Genome annotation databases

EnsemblBacteriaiAAG58825; AAG58825; Z5112
BAB37984; BAB37984; ECs_4561
GeneIDi915465
KEGGiece:Z5112
ecs:ECs4561
PATRICifig|386585.9.peg.4778

Phylogenomic databases

eggNOGiENOG5033PQE, Bacteria
HOGENOMiCLU_497576_0_0_6

Miscellaneous databases

EvolutionaryTraceiQ7DB77

Family and domain databases

Gene3Di4.10.820.10, 1 hit
InterProiView protein in InterPro
IPR037003, Tir_central_sf
IPR022638, Transloc_intimin_rcpt
IPR022639, Transloc_intimin_rcpt_C
IPR003536, Transloc_intimin_rcpt_cen_dom
IPR022633, Transloc_intimin_rcpt_N
PfamiView protein in Pfam
PF07489, Tir_receptor_C, 1 hit
PF03549, Tir_receptor_M, 1 hit
PF07490, Tir_receptor_N, 1 hit
PRINTSiPR01370, TRNSINTIMINR

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIR_ECO57
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7DB77
Secondary accession number(s): Q7A9Q1, Q9R396
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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