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UniProtKB - Q7CZ84 (Q7CZ84_AGRFC)

Entry version 122 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

DNA-binding transcriptional regulator NtrC

Gene

ntrC

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation, RepressorUniRule annotation
Biological processNitrogen fixationUniRule annotation, Transcription, Transcription regulationUniRule annotationARBA annotation, Two-component regulatory systemUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		AGRO:ATU1446-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-binding transcriptional regulator NtrCUniRule annotationARBA annotation
Alternative name(s):
Nitrogen regulation protein NR(I)UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ntrCUniRule annotationImported
Ordered Locus Names:Atu1446Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri176299 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium › Agrobacterium tumefaciens complex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000813 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome circular

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

CytoplasmUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		176299.Atu1446

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 118Response regulatoryInterPro annotationAdd BLAST115
Domaini138 – 366Sigma-54 factor interactionInterPro annotationAdd BLAST229

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG2204, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000445_0_1_5

KEGG Orthology (KO)

More...KOi		K07712

Identification of Orthologs from Complete Genome Data

More...OMAi		DWTGNIR

Family and domain databases

Conserved Domains Database

More...CDDi		cd00156, REC, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR011006, CheY-like_superfamily
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR001789, Sig_transdc_resp-reg_receiver
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS
IPR010114, Trancript_reg_NtrC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02954, HTH_8, 1 hit
PF00072, Response_reg, 1 hit
PF00158, Sigma54_activat, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01590, HTHFIS

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF52172, SSF52172, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01818, ntrC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50110, RESPONSE_REGULATORY, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7CZ84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTATILVADD DAAIRTVLNQ ALSRAGYDVR ITSNAATLWR WVSAGEGDLV 
        60         70         80         90        100
VTDVVMPDEN AFDLLPRIKK ARPDLPVLVM SAQNTFMTAI KASEKGAYDY 
       110        120        130        140        150
LPKPFDLTEL IAIIGRALSE PKRKPAKLDD DMQDGMPLVG RSAAMQEIYR 
       160        170        180        190        200
VLARLMQTDL TLMITGESGT GKELVARALH DYGKRRNGPF VAINMAAIPR 
       210        220        230        240        250
DLIESELFGH EKGAFTGAQN RSTGRFEQAE GGTLFLDEIG DMPMDAQTRL 
       260        270        280        290        300
LRVLQQGEYT TVGGRTPIRT DVRIVAATNK DLKQSINQGL FREDLYYRLN 
       310        320        330        340        350
VVPLRLPPLR DRAEDIPDLV RHFIQTGEKE GLEGKRFETE ALEVMKAYAW 
       360        370        380        390        400
PGNVRELENL IRRLMALYPQ EVITREIIEQ ELQSDVPDSP LDKMAVRTGS 
       410        420        430        440        450
LTISQAVEEN MRDYFASFGD GLPPPGLYDR VLRELEYPLI LAALTATRGN 
       460        470        480 
QIKAADLLGL NRNTLRKKIR ELGVSVYRSS RPS
Length:483
Mass (Da):53,917
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i895810B4ECA0912A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK87237.1

NCBI Reference Sequences

More...RefSeqi		NP_354452.1, NC_003062.2
WP_004441656.1, NC_003062.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAK87237; AAK87237; Atu1446

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1133484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		atu:Atu1446

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|176299.10.peg.1467

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK87237.1
RefSeqiNP_354452.1, NC_003062.2
WP_004441656.1, NC_003062.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi176299.Atu1446

Genome annotation databases

EnsemblBacteriaiAAK87237; AAK87237; Atu1446
GeneIDi1133484
KEGGiatu:Atu1446
PATRICifig|176299.10.peg.1467

Phylogenomic databases

eggNOGiCOG2204, Bacteria
HOGENOMiCLU_000445_0_1_5
KOiK07712
OMAiDWTGNIR

Enzyme and pathway databases

BioCyciAGRO:ATU1446-MONOMER

Family and domain databases

CDDicd00156, REC, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011006, CheY-like_superfamily
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR001789, Sig_transdc_resp-reg_receiver
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS
IPR010114, Trancript_reg_NtrC
PfamiView protein in Pfam
PF02954, HTH_8, 1 hit
PF00072, Response_reg, 1 hit
PF00158, Sigma54_activat, 1 hit
PRINTSiPR01590, HTHFIS
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00448, REC, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF52172, SSF52172, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01818, ntrC, 1 hit
PROSITEiView protein in PROSITE
PS50110, RESPONSE_REGULATORY, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7CZ84_AGRFC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7CZ84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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