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Entry version 112 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Penicillin-binding protein 1b

Gene

pbp1b

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseImported, GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SPNE171101:SPR1909-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT51 Glycosyltransferase Family 51

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Penicillin-binding protein 1bImported (EC:2.3.2.-Imported, EC:2.4.1.129Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pbp1bImported
Ordered Locus Names:spr1909Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri171101 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000586 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 84HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB01140 Cefadroxil
DB00456 Cefalotin
DB00493 Cefotaxime
DB01331 Cefoxitin
DB00567 Cephalexin
DB03313 Cephalosporin C
DB00485 Dicloxacillin
DB00739 Hetacillin
DB01603 Meticillin
DB08508 N-BENZOYL-D-ALANINE
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
171101.spr1909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UWXX-ray2.39A321-791[»]
2XD1X-ray3.00A/B321-791[»]
2XD5X-ray2.50A/B323-791[»]
2Y2GX-ray2.05A/B321-791[»]
2Y2HX-ray1.96A/B321-791[»]
2Y2IX-ray1.78A321-791[»]
2Y2JX-ray2.06A321-791[»]
2Y2KX-ray2.09A321-791[»]
2Y2LX-ray2.07A/B321-791[»]
2Y2MX-ray1.62A321-791[»]
2Y2NX-ray2.07A321-791[»]
2Y2OX-ray1.88A321-791[»]
2Y2PX-ray1.62A321-791[»]
2Y2QX-ray2.15A/B321-791[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7CRA4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7CRA4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 302TransglyInterPro annotationAdd BLAST190
Domaini425 – 657TranspeptidaseInterPro annotationAdd BLAST233

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZ4 Bacteria
COG0744 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000235110

KEGG Orthology (KO)

More...
KOi
K03693

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADWAGKT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3810.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR001460 PCN-bd_Tpept

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7CRA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNQLNELKR KMLEFFQQKQ KNKKSARPGK KGSSTKKSKT LDKSAIFPAI
60 70 80 90 100
LLSIKALFNL LFVLGFLGGM LGAGIALGYG VALFDKVRVP QTEELVNQVK
110 120 130 140 150
DISSISEITY SDGTVIASIE SDLLRTSISS EQISENLKKA IIATEDEHFK
160 170 180 190 200
EHKGVVPKAV IRATLGKFVG LGSSSGGSTL TQQLIKQQVV GDAPTLARKA
210 220 230 240 250
AEIVDALALE RAMNKDEILT TYLNVAPFGR NNKGQNIAGA RQAAEGIFGV
260 270 280 290 300
DASQLTVPQA AFLAGLPQSP ITYSPYENTG ELKSDEDLEI GLRRAKAVLY
310 320 330 340 350
SMYRTGALSK DEYSQYKDYD LKQDFLPSGT VTGISRDYLY FTTLAEAQER
360 370 380 390 400
MYDYLAQRDN VSAKELKNEA TQKFYRDLAA KEIENGGYKI TTTIDQKIHS
410 420 430 440 450
AMQSAVADYG YLLDDGTGRV EVGNVLMDNQ TGAILGFVGG RNYQENQNNH
460 470 480 490 500
AFDTKRSPAS TTKPLLAYGI AIDQGLMGSE TILSNYPTNF ANGNPIMYAN
510 520 530 540 550
SKGTGMMTLG EALNYSWNIP AYWTYRMLRE NGVDVKGYME KMGYEIPEYG
560 570 580 590 600
IESLPMGGGI EVTVAQHTNG YQTLANNGVY HQKHVISKIE AADGRVVYEY
610 620 630 640 650
QDKPVQVYSK ATATIMQGLL REVLSSRVTT TFKSNLTSLN PTLANADWIG
660 670 680 690 700
KTGTTNQDEN MWLMLSTPRL TLGGWIGHDD NHSLSRRAGY SNNSNYMAHL
710 720 730 740 750
VNAIQQASPS IWGNERFALD PSVVKSEVLK STGQKPGKVS VEGKEVEVTG
760 770 780 790 800
STVTSYWANK SGAPATSYRF AIGGSDADYQ NAWSSIVGSL PTPSSSSSSS
810 820
SSSSDSSNSS TTRPSSSRAR R
Length:821
Mass (Da):89,481
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA94560B4B8BD3AB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00711.1

NCBI Reference Sequences

More...
RefSeqi
NP_359500.1, NC_003098.1
WP_001180963.1, NC_003098.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL00711; AAL00711; spr1909

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
934893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spr:spr1909

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|171101.6.peg.2058

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00711.1
RefSeqiNP_359500.1, NC_003098.1
WP_001180963.1, NC_003098.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UWXX-ray2.39A321-791[»]
2XD1X-ray3.00A/B321-791[»]
2XD5X-ray2.50A/B323-791[»]
2Y2GX-ray2.05A/B321-791[»]
2Y2HX-ray1.96A/B321-791[»]
2Y2IX-ray1.78A321-791[»]
2Y2JX-ray2.06A321-791[»]
2Y2KX-ray2.09A321-791[»]
2Y2LX-ray2.07A/B321-791[»]
2Y2MX-ray1.62A321-791[»]
2Y2NX-ray2.07A321-791[»]
2Y2OX-ray1.88A321-791[»]
2Y2PX-ray1.62A321-791[»]
2Y2QX-ray2.15A/B321-791[»]
SMRiQ7CRA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr1909

Chemistry databases

DrugBankiDB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB01140 Cefadroxil
DB00456 Cefalotin
DB00493 Cefotaxime
DB01331 Cefoxitin
DB00567 Cephalexin
DB03313 Cephalosporin C
DB00485 Dicloxacillin
DB00739 Hetacillin
DB01603 Meticillin
DB08508 N-BENZOYL-D-ALANINE
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL00711; AAL00711; spr1909
GeneIDi934893
KEGGispr:spr1909
PATRICifig|171101.6.peg.2058

Phylogenomic databases

eggNOGiENOG4105BZ4 Bacteria
COG0744 LUCA
HOGENOMiHOG000235110
KOiK03693
OMAiADWAGKT

Enzyme and pathway databases

BioCyciSPNE171101:SPR1909-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ7CRA4

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7CRA4_STRR6
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7CRA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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