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Protein
Submitted name:

Penicillin-binding protein 1b

Gene

pbp1b

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseImported, GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciSPNE171101:SPR1909-MONOMER

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Names & Taxonomyi

Protein namesi
Submitted name:
Penicillin-binding protein 1bImported (EC:2.3.2.-Imported, EC:2.4.1.129Imported)
Gene namesi
Name:pbp1bImported
Ordered Locus Names:spr1909Imported
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 84HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB01140 Cefadroxil
DB00456 Cefalotin
DB00493 Cefotaxime
DB01331 Cefoxitin
DB00567 Cephalexin
DB03313 Cephalosporin C
DB00485 Dicloxacillin
DB00739 Hetacillin
DB01603 Meticillin
DB08508 N-BENZOYL-D-ALANINE
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1909

Structurei

3D structure databases

ProteinModelPortaliQ7CRA4
SMRiQ7CRA4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CRA4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 302TransglyInterPro annotationAdd BLAST190
Domaini425 – 657TranspeptidaseInterPro annotationAdd BLAST233

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105BZ4 Bacteria
COG0744 LUCA
HOGENOMiHOG000235110
KOiK03693
OMAiADWAGKT

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit

Sequencei

Sequence statusi: Complete.

Q7CRA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNQLNELKR KMLEFFQQKQ KNKKSARPGK KGSSTKKSKT LDKSAIFPAI
60 70 80 90 100
LLSIKALFNL LFVLGFLGGM LGAGIALGYG VALFDKVRVP QTEELVNQVK
110 120 130 140 150
DISSISEITY SDGTVIASIE SDLLRTSISS EQISENLKKA IIATEDEHFK
160 170 180 190 200
EHKGVVPKAV IRATLGKFVG LGSSSGGSTL TQQLIKQQVV GDAPTLARKA
210 220 230 240 250
AEIVDALALE RAMNKDEILT TYLNVAPFGR NNKGQNIAGA RQAAEGIFGV
260 270 280 290 300
DASQLTVPQA AFLAGLPQSP ITYSPYENTG ELKSDEDLEI GLRRAKAVLY
310 320 330 340 350
SMYRTGALSK DEYSQYKDYD LKQDFLPSGT VTGISRDYLY FTTLAEAQER
360 370 380 390 400
MYDYLAQRDN VSAKELKNEA TQKFYRDLAA KEIENGGYKI TTTIDQKIHS
410 420 430 440 450
AMQSAVADYG YLLDDGTGRV EVGNVLMDNQ TGAILGFVGG RNYQENQNNH
460 470 480 490 500
AFDTKRSPAS TTKPLLAYGI AIDQGLMGSE TILSNYPTNF ANGNPIMYAN
510 520 530 540 550
SKGTGMMTLG EALNYSWNIP AYWTYRMLRE NGVDVKGYME KMGYEIPEYG
560 570 580 590 600
IESLPMGGGI EVTVAQHTNG YQTLANNGVY HQKHVISKIE AADGRVVYEY
610 620 630 640 650
QDKPVQVYSK ATATIMQGLL REVLSSRVTT TFKSNLTSLN PTLANADWIG
660 670 680 690 700
KTGTTNQDEN MWLMLSTPRL TLGGWIGHDD NHSLSRRAGY SNNSNYMAHL
710 720 730 740 750
VNAIQQASPS IWGNERFALD PSVVKSEVLK STGQKPGKVS VEGKEVEVTG
760 770 780 790 800
STVTSYWANK SGAPATSYRF AIGGSDADYQ NAWSSIVGSL PTPSSSSSSS
810 820
SSSSDSSNSS TTRPSSSRAR R
Length:821
Mass (Da):89,481
Last modified:July 5, 2004 - v1
Checksum:iDA94560B4B8BD3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00711.1
RefSeqiNP_359500.1, NC_003098.1
WP_001180963.1, NC_003098.1

Genome annotation databases

EnsemblBacteriaiAAL00711; AAL00711; spr1909
GeneIDi934893
KEGGispr:spr1909
PATRICifig|171101.6.peg.2058

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00711.1
RefSeqiNP_359500.1, NC_003098.1
WP_001180963.1, NC_003098.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2UWXX-ray2.39A321-791[»]
2XD1X-ray3.00A/B321-791[»]
2XD5X-ray2.50A/B323-791[»]
2Y2GX-ray2.05A/B321-791[»]
2Y2HX-ray1.96A/B321-791[»]
2Y2IX-ray1.78A321-791[»]
2Y2JX-ray2.06A321-791[»]
2Y2KX-ray2.09A321-791[»]
2Y2LX-ray2.07A/B321-791[»]
2Y2MX-ray1.62A321-791[»]
2Y2NX-ray2.07A321-791[»]
2Y2OX-ray1.88A321-791[»]
2Y2PX-ray1.62A321-791[»]
2Y2QX-ray2.15A/B321-791[»]
ProteinModelPortaliQ7CRA4
SMRiQ7CRA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr1909

Chemistry databases

DrugBankiDB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB01140 Cefadroxil
DB00456 Cefalotin
DB00493 Cefotaxime
DB01331 Cefoxitin
DB00567 Cephalexin
DB03313 Cephalosporin C
DB00485 Dicloxacillin
DB00739 Hetacillin
DB01603 Meticillin
DB08508 N-BENZOYL-D-ALANINE
DB00607 Nafcillin
DB00713 Oxacillin
DB00319 Piperacillin

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL00711; AAL00711; spr1909
GeneIDi934893
KEGGispr:spr1909
PATRICifig|171101.6.peg.2058

Phylogenomic databases

eggNOGiENOG4105BZ4 Bacteria
COG0744 LUCA
HOGENOMiHOG000235110
KOiK03693
OMAiADWAGKT

Enzyme and pathway databases

BioCyciSPNE171101:SPR1909-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ7CRA4

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7CRA4_STRR6
AccessioniPrimary (citable) accession number: Q7CRA4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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