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Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
  2. Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)
This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00036; UER00496

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesi
Name:arnDUniRule annotation
Ordered Locus Names:YPO2419, y1920, YP_2206
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003835511 – 301Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDAdd BLAST301

Proteomic databases

PaxDbiQ7CIT9

Interactioni

Protein-protein interaction databases

IntActiQ7CIT9, 1 interactor
STRINGi187410.y1920

Structurei

3D structure databases

ProteinModelPortaliQ7CIT9
SMRiQ7CIT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 261NodB homologyUniRule annotationAdd BLAST260

Sequence similaritiesi

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F73 Bacteria
COG0726 LUCA
HOGENOMiHOG000261199
KOiK13014
OMAiKFLWKML

Family and domain databases

HAMAPiMF_01870 ArnD, 1 hit
InterProiView protein in InterPro
IPR023557 ArnD
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR002509 NODB_dom
PfamiView protein in Pfam
PF01522 Polysacc_deac_1, 1 hit
SUPFAMiSSF88713 SSF88713, 2 hits
PROSITEiView protein in PROSITE
PS51677 NODB, 1 hit

Sequencei

Sequence statusi: Complete.

Q7CIT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVGLRIDV DTYRGTQYGV PSLLTVLEKH DIRASFFFSV GPDNMGRHLW
60 70 80 90 100
RLFRPRFLWK MLRSNAASLY GWDILLAGTA WPGKKIAKDF GPLMKAAAMA
110 120 130 140 150
GHEVGLHAWD HQGWQANVAS WSQQQLTEQV QRGVDTLQQS IGQPISCSAA
160 170 180 190 200
AGWRADERVL AVKQQFDFSY NSDCRGTHPF RPLLPNGSLG SVQIPVTLPT
210 220 230 240 250
YDEVVGGEVQ AENFNDFIID AILRDSGVSV YTIHAEVEGM SQAAMFEQLL
260 270 280 290 300
MRAKQQDIEF CPLSKLLPSD LQLLPVGKVI RAAFPGREGW LGCQSDIKDA

E
Length:301
Mass (Da):33,504
Last modified:July 5, 2004 - v1
Checksum:iABA3A1132D09A864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA Translation: CAL21046.1
AE009952 Genomic DNA Translation: AAM85487.1
AE017042 Genomic DNA Translation: AAS62412.1
PIRiAC0295
RefSeqiWP_002211822.1, NZ_PVMU01000029.1
YP_002347382.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85487; AAM85487; y1920
AAS62412; AAS62412; YP_2206
GeneIDi1175252
KEGGiype:YPO2419
ypj:CH55_495
ypk:y1920
ypl:CH46_2686
ypm:YP_2206
ypv:BZ15_1106
ypw:CH59_4253
PATRICifig|1028802.3.peg.1779

Similar proteinsi

Entry informationi

Entry nameiARND_YERPE
AccessioniPrimary (citable) accession number: Q7CIT9
Secondary accession number(s): Q74TF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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