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Entry version 78 (10 Feb 2021)
Sequence version 2 (26 Apr 2005)
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Protein

Hyaluronan synthase

Gene

hyaD

Organism
Pasteurella multocida
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the polymerization of hyaluronan, a polysaccharide composed of a repeating disaccharide of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) units. Each unit has the composition in beta-(1->4)-GlcUA-beta-(1->3)-GlcNAc.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+, Co2+

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=160 µM for UDP-N-acetyl-D-glucosamine
  2. KM=140 µM for UDP-D-glucuronate

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Multifunctional enzyme, Transferase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.212, 4558

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q7BLV3

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT2, Glycosyltransferase Family 2

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hyaluronan synthase (EC:2.4.1.212)
    Including the following 2 domains:
    Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-beta-N-acetylglucosaminyltransferase
    Alternative name(s):
    UDP-GlcNAc transferase
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC:2.4.1.226)
    Alternative name(s):
    UDP-GlcUA transferase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:hyaD
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPasteurella multocida
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri747 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi196D → E, K or N: Complete loss of GlcNAc transferase activity. 1 Publication1
    Mutagenesisi247D → E, K or N: Complete loss of GlcNAc transferase activity. 1 Publication1
    Mutagenesisi249D → E, K or N: Complete loss of GlcNAc transferase activity. 1 Publication1
    Mutagenesisi369E → D: Complete loss of GlcNAc transferase activity. Regains 30% of wild-type activity at high UDP-GlcNAc concentrations. 1 Publication1
    Mutagenesisi369E → H or Q: Complete loss of GlcNAc transferase activity. 1 Publication1
    Mutagenesisi370D → E, K or N: Complete loss of GlcNAc transferase activity. 1 Publication1
    Mutagenesisi477D → E, K or N: Complete loss of GlcUA transferase activity. 1 Publication1
    Mutagenesisi527D → E, K or N: Complete loss of GlcUA transferase activity. 1 Publication1
    Mutagenesisi529D → E: 90% loss of GlcUA transferase activity. 1 Publication1
    Mutagenesisi529D → K or N: Complete loss of GlcUA transferase activity. 1 Publication1
    Mutagenesisi563D → E, K or N: No effect. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000592591 – 972Hyaluronan synthaseAdd BLAST972

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q7BLV3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 325A1Add BLAST174
    Regioni432 – 604A2Add BLAST173

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.550.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001173, Glyco_trans_2-like
    IPR029044, Nucleotide-diphossugar_trans

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00535, Glycos_transf_2, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53448, SSF53448, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q7BLV3-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MNTLSQAIKA YNSNDYQLAL KLFEKSAEIY GRKIVEFQIT KCKEKLSAHP
    60 70 80 90 100
    SVNSAHLSVN KEEKVNVCDS PLDIATQLLL SNVKKLVLSD SEKNTLKNKW
    110 120 130 140 150
    KLLTEKKSEN AEVRAVALVP KDFPKDLVLA PLPDHVNDFT WYKKRKKRLG
    160 170 180 190 200
    IKPEHQHVGL SIIVTTFNRP AILSITLACL VNQKTHYPFE VIVTDDGSQE
    210 220 230 240 250
    DLSPIIRQYE NKLDIRYVRQ KDNGFQASAA RNMGLRLAKY DFIGLLDCDM
    260 270 280 290 300
    APNPLWVHSY VAELLEDDDL TIIGPRKYID TQHIDPKDFL NNASLLESLP
    310 320 330 340 350
    EVKTNNSVAA KGEGTVSLDW RLEQFEKTEN LRLSDSPFRF FAAGNVAFAK
    360 370 380 390 400
    KWLNKSGFFD EEFNHWGGED VEFGYRLFRY GSFFKTIDGI MAYHQEPPGK
    410 420 430 440 450
    ENETDREAGK NITLDIMREK VPYIYRKLLP IEDSHINRVP LVSIYIPAYN
    460 470 480 490 500
    CANYIQRCVD SALNQTVVDL EVCICNDGST DNTLEVINKL YGNNPRVRIM
    510 520 530 540 550
    SKPNGGIASA SNAAVSFAKG YYIGQLDSDD YLEPDAVELC LKEFLKDKTL
    560 570 580 590 600
    ACVYTTNRNV NPDGSLIANG YNWPEFSREK LTTAMIAHHF RMFTIRAWHL
    610 620 630 640 650
    TDGFNEKIEN AVDYDMFLKL SEVGKFKHLN KICYNRVLHG DNTSIKKLGI
    660 670 680 690 700
    QKKNHFVVVN QSLNRQGITY YNYDEFDDLD ESRKYIFNKT AEYQEEIDIL
    710 720 730 740 750
    KDIKIIQNKD AKIAVSIFYP NTLNGLVKKL NNIIEYNKNI FVIVLHVDKN
    760 770 780 790 800
    HLTPDIKKEI LAFYHKHQVN ILLNNDISYY TSNRLIKTEA HLSNINKLSQ
    810 820 830 840 850
    LNLNCEYIIF DNHDSLFVKN DSYAYMKKYD VGMNFSALTH DWIEKINAHP
    860 870 880 890 900
    PFKKLIKTYF NDNDLKSMNV KGASQGMFMT YALAHELLTI IKEVITSCQS
    910 920 930 940 950
    IDSVPEYNTE DIWFQFALLI LEKKTGHVFN KTSTLTYMPW ERKLQWTNEQ
    960 970
    IESAKRGENI PVNKFIINSI TL
    Length:972
    Mass (Da):111,839
    Last modified:April 26, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD933BD8C1E923685
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17Q → E in AAC67250 (PubMed:9770287).Curated1
    Sequence conflicti43K → Q in AAF68412 (PubMed:10873488).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF067175 Genomic DNA Translation: AAC67250.2
    AF036004 Genomic DNA Translation: AAC38318.2
    AF237926 Genomic DNA Translation: AAF68412.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T09595

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_005754202.1, NZ_MAPR01000001.1
    WP_016504510.1, NZ_UGSU01000002.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF067175 Genomic DNA Translation: AAC67250.2
    AF036004 Genomic DNA Translation: AAC38318.2
    AF237926 Genomic DNA Translation: AAF68412.1
    PIRiT09595
    RefSeqiWP_005754202.1, NZ_MAPR01000001.1
    WP_016504510.1, NZ_UGSU01000002.1

    3D structure databases

    SMRiQ7BLV3
    ModBaseiSearch...

    Protein family/group databases

    CAZyiGT2, Glycosyltransferase Family 2

    Enzyme and pathway databases

    BRENDAi2.4.1.212, 4558
    SABIO-RKiQ7BLV3

    Family and domain databases

    Gene3Di3.90.550.10, 2 hits
    InterProiView protein in InterPro
    IPR001173, Glyco_trans_2-like
    IPR029044, Nucleotide-diphossugar_trans
    PfamiView protein in Pfam
    PF00535, Glycos_transf_2, 2 hits
    SUPFAMiSSF53448, SSF53448, 2 hits

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAS_PASMD
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7BLV3
    Secondary accession number(s): O68389, O85457
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: February 10, 2021
    This is version 78 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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