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Entry version 114 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

NAD(P)H nitroreductase

Gene

frxA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei42FMNCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi13 – 17FMNCombined sources5
Nucleotide bindingi162 – 165FMNCombined sources4
Nucleotide bindingi204 – 206FMNCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandFlavoprotein, FMNCombined sources, Nucleotide-bindingCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NAD(P)H nitroreductaseImported
Submitted name:
NAD(P)H-dependent oxidoreductaseImported
Submitted name:
NADPH-flavin oxidoreductaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:frxAImported
ORF Names:BB397_06830Imported, C2840_03330Imported, C2844_03325Imported, C2R45_03525Imported, C2R53_07115Imported, C2R80_05000Imported, C2R82_03790Imported, C2R91_01680Imported, C2S01_06315Imported, C2S02_00170Imported, C2S07_02150Imported, C2S30_05055Imported, C2S42_01405Imported, C2S44_05455Imported, C2S45_01905Imported, CEP78_002895Imported, DD744_03375Imported, DD748_03855Imported, DD749_03405Imported, DD767_02880Imported, DD778_03010Imported, DDP35_03535Imported, DDP51_03415Imported, EC527_03545Imported, EC550_05940Imported, ECC20_07225Imported, HPY499_05790Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (Campylobacter pylori)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000244706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000244843 Componenti: Unassembled WGS sequence
  • UP000239200 Componenti: Chromosome
  • UP000282660 Componenti: Unassembled WGS sequence
  • UP000279902 Componenti: Unassembled WGS sequence
  • UP000278812 Componenti: Unassembled WGS sequence
  • UP000244736 Componenti: Unassembled WGS sequence
  • UP000244317 Componenti: Unassembled WGS sequence
  • UP000275758 Componenti: Unassembled WGS sequence
  • UP000288746 Componenti: Unassembled WGS sequence
  • UP000244566 Componenti: Unassembled WGS sequence
  • UP000244280 Componenti: Unassembled WGS sequence
  • UP000220119 Componenti: Unassembled WGS sequence
  • UP000244781 Componenti: Unassembled WGS sequence
  • UP000244532 Componenti: Unassembled WGS sequence
  • UP000244440 Componenti: Unassembled WGS sequence
  • UP000271397 Componenti: Unassembled WGS sequence
  • UP000236564 Componenti: Chromosome
  • UP000031018 Componenti: Unassembled WGS sequence
  • UP000244348 Componenti: Unassembled WGS sequence
  • UP000244565 Componenti: Unassembled WGS sequence
  • UP000271571 Componenti: Unassembled WGS sequence
  • UP000288833 Componenti: Unassembled WGS sequence
  • UP000288822 Componenti: Unassembled WGS sequence
  • UP000256776 Componenti: Unassembled WGS sequence
  • UP000244414 Componenti: Unassembled WGS sequence
  • UP000198044 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7505370,EBI-7505370

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 176NitroreductaseInterPro annotationAdd BLAST165

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108RCM Bacteria
COG0778 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02149 NfsB_like_nitroreductase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.109.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033878 NfsB-like
IPR029479 Nitroreductase
IPR000415 Nitroreductase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00881 Nitroreductase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55469 SSF55469, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7BGI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDREQVVALQ HQRFAAKKYD PNRRISQKDW EALVEVGRLA PSSIGLEPWK
60 70 80 90 100
MLLLKNERMK EDLKPMAWGA LFGLEGASHF VIYLARKGVT YDSDYVKKVM
110 120 130 140 150
HEVKKRDYDT NSRFAQIIKN FQENDMKLNS ERSLFDWASK QTYIQMANMM
160 170 180 190 200
MAAAMLGIDS CPIEGYDQEK VEAYLEEKGY LNTAEFGVSV MACFGYRNQE
210
ITPKTRWKTE VIYEVIE
Length:217
Mass (Da):25,293
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07330EC11ACB7AA6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF322959 Genomic DNA Translation: AAL37257.1
AF322960 Genomic DNA Translation: AAL37258.1
CP026326 Genomic DNA Translation: AUV77824.1
CP026515 Genomic DNA Translation: AUZ23854.1
JTDG01000029 Genomic DNA Translation: KHL90027.1
MBIF01000010 Genomic DNA Translation: PDW98792.1
NJFC02000001 Genomic DNA Translation: PNL41355.1
QBPK01000005 Genomic DNA Translation: PUB94546.1
QBPU01000024 Genomic DNA Translation: PUB99353.1
QBPW01000008 Genomic DNA Translation: PUD02021.1
QBPX01000031 Genomic DNA Translation: PUD03201.1
QBQC01000013 Genomic DNA Translation: PUD03862.1
QBQJ01000021 Genomic DNA Translation: PUD15471.1
QBQL01000024 Genomic DNA Translation: PUD19551.1
QBPH01000018 Genomic DNA Translation: PUD19737.1
QBPI01000094 Genomic DNA Translation: PUD22950.1
QBPP01000039 Genomic DNA Translation: PUD23186.1
QBRL01000041 Genomic DNA Translation: PUD80922.1
QBRT01000077 Genomic DNA Translation: PUD86764.1
QDJM01000007 Genomic DNA Translation: RDY81239.1
QDJS01000009 Genomic DNA Translation: RKV10106.1
QEGG01000012 Genomic DNA Translation: RKV18608.1
QEGI01000011 Genomic DNA Translation: RKV21786.1
QEGJ01000009 Genomic DNA Translation: RKV22819.1
QEGX01000015 Genomic DNA Translation: RKV44272.1
QEGY01000016 Genomic DNA Translation: RKV46828.1
RJEV01000016 Genomic DNA Translation: RVY37340.1
RJGU01000004 Genomic DNA Translation: RVZ12634.1
RJHN01000014 Genomic DNA Translation: RVZ44883.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B64600

NCBI Reference Sequences

More...
RefSeqi
WP_000373527.1, NZ_RJHN01000014.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
KHL90027; KHL90027; HPY499_05790

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1111674.3.peg.1309

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322959 Genomic DNA Translation: AAL37257.1
AF322960 Genomic DNA Translation: AAL37258.1
CP026326 Genomic DNA Translation: AUV77824.1
CP026515 Genomic DNA Translation: AUZ23854.1
JTDG01000029 Genomic DNA Translation: KHL90027.1
MBIF01000010 Genomic DNA Translation: PDW98792.1
NJFC02000001 Genomic DNA Translation: PNL41355.1
QBPK01000005 Genomic DNA Translation: PUB94546.1
QBPU01000024 Genomic DNA Translation: PUB99353.1
QBPW01000008 Genomic DNA Translation: PUD02021.1
QBPX01000031 Genomic DNA Translation: PUD03201.1
QBQC01000013 Genomic DNA Translation: PUD03862.1
QBQJ01000021 Genomic DNA Translation: PUD15471.1
QBQL01000024 Genomic DNA Translation: PUD19551.1
QBPH01000018 Genomic DNA Translation: PUD19737.1
QBPI01000094 Genomic DNA Translation: PUD22950.1
QBPP01000039 Genomic DNA Translation: PUD23186.1
QBRL01000041 Genomic DNA Translation: PUD80922.1
QBRT01000077 Genomic DNA Translation: PUD86764.1
QDJM01000007 Genomic DNA Translation: RDY81239.1
QDJS01000009 Genomic DNA Translation: RKV10106.1
QEGG01000012 Genomic DNA Translation: RKV18608.1
QEGI01000011 Genomic DNA Translation: RKV21786.1
QEGJ01000009 Genomic DNA Translation: RKV22819.1
QEGX01000015 Genomic DNA Translation: RKV44272.1
QEGY01000016 Genomic DNA Translation: RKV46828.1
RJEV01000016 Genomic DNA Translation: RVY37340.1
RJGU01000004 Genomic DNA Translation: RVZ12634.1
RJHN01000014 Genomic DNA Translation: RVZ44883.1
PIRiB64600
RefSeqiWP_000373527.1, NZ_RJHN01000014.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H0UX-ray1.90A1-217[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiKHL90027; KHL90027; HPY499_05790
PATRICifig|1111674.3.peg.1309

Phylogenomic databases

eggNOGiENOG4108RCM Bacteria
COG0778 LUCA

Family and domain databases

CDDicd02149 NfsB_like_nitroreductase, 1 hit
Gene3Di3.40.109.10, 1 hit
InterProiView protein in InterPro
IPR033878 NfsB-like
IPR029479 Nitroreductase
IPR000415 Nitroreductase-like
PfamiView protein in Pfam
PF00881 Nitroreductase, 1 hit
SUPFAMiSSF55469 SSF55469, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7BGI8_HELPX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7BGI8
Secondary accession number(s): O25359
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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