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Entry version 147 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Site-specific DNA-methyltransferase (adenine-specific)

Gene

hsdM

Organism
Campylobacter jejuni
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseImportedARBA annotation, Transferase
Biological processRestriction systemARBA annotation
LigandS-adenosyl-L-methionineARBA annotation

Protein family/group databases

Restriction enzymes and methylases database

More...
REBASEi
6013, M.Cje43430ORFAP
6091, M.Cje1849ORFAP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Site-specific DNA-methyltransferase (adenine-specific)ARBA annotation (EC:2.1.1.72ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hsdMImported
ORF Names:A4277_02530Imported, B5660_05030Imported, B6999_08535Imported, B7A03_08255Imported, BBJ87_04150Imported, BFD99_06600Imported, BM409_05285Imported, BZN49_06455Imported, C1418_05055Imported, C3W58_08900Imported, C5M81_05580Imported, CBW88_07695Imported, CII86_08045Imported, CUT57_01850Imported, CXE90_08330Imported, D1F07_08180Imported, D6H09_08260Imported, DCB46_06180Imported, DDV78_05225Imported, DW573_08795Imported, DZC48_07825Imported, E7M04_06785Imported, E7O26_06670Imported, E7P31_04490Imported, E7P36_06280Imported, E7S95_04365Imported, E8P01_07080Imported, F0N28_07175Imported, F0O82_08465Imported, F1F23_06115Imported, F1P05_00680Imported, F6069_06760Imported, F6306_04100Imported, F7843_04950Imported, F7N67_04405Imported, FCQ00_07540Imported, FM724_05595Imported, FNW64_07120Imported, FPN50_06490Imported, FW006_00040Imported, FW073_03325Imported, FW865_02060Imported, FZ832_01045Imported, GAU91_04010Imported, GC726_03875Imported, GC764_08440Imported, GIE70_08350Imported, GJO28_03195Imported, GQV25_06835Imported, GS409_03770Imported, GWF31_06655Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCampylobacter jejuniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri197 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 138HsdM_NInterPro annotationAdd BLAST130
Domaini148 – 462N6_MtaseInterPro annotationAdd BLAST315

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.ARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1260.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022749, D12N6_MeTrfase_N
IPR038333, D12N6_MeTrfase_N_sf
IPR003356, DNA_methylase_A-5
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12161, HsdM_N, 1 hit
PF02384, N6_Mtase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00092, N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7B7V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKKEIKLE DALWKSADKL RKNIDAAEYK HIVLGLIFLR YISDSFMQKY
60 70 80 90 100
EELLKEQDDG ADPEDADEYL ADNIFFVPEK SRYNYIRDNA KNPKIGKMLD
110 120 130 140 150
EAMDEIEKHN DTLKGVLPKV YAKDNLDSKC LGELIDLIGN IAFDTGKSTD
160 170 180 190 200
VLGHVFEYFL GEFALAEGKQ GGQFYTPKCV VELLVTMLEP YKGRVFDPCC
210 220 230 240 250
GSGGMFVQSE EFVKSHQGRL DDISIYGQES NQTTYKLAKM NLAIRKIESS
260 270 280 290 300
QVIWNNEGSF LNDAHKDLKA DFIIANPPFN DSDWSGELLE NDGRWKYGVP
310 320 330 340 350
PASNANYAWI QHFLYHLSPN GGVAGFVLAK GALTSNTTNE AAIRKALIED
360 370 380 390 400
DLIDCIVNLP AKLFLNTGIP ASLWFIRRQK LPKTVKKTLF IDARDLGTRI
410 420 430 440 450
NRRNKTLNKD DINQIANIYK AWKNGTDYED IKGFCKSVSI DEIRELSYVL
460 470 480 490 500
TPGRYVGLAD SDDEFDFDTR FNELLAKLKS QIKTEQELSE IILKNLEKIK
Length:500
Mass (Da):56,790
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB893823DD72CC8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF486544 Genomic DNA Translation: AAM00822.1
AF486551 Genomic DNA Translation: AAM00854.1
AF486558 Genomic DNA Translation: AAM00889.1
AAAEXG010000023 Genomic DNA Translation: EAB5309620.1
AACBFH010000006 Genomic DNA Translation: EAJ8462090.1
AACFGQ010000019 Genomic DNA Translation: EAK3187109.1
AACFRH010000005 Genomic DNA Translation: EAK3705092.1
AACFRW010000010 Genomic DNA Translation: EAK3794915.1
AACFWJ010000004 Genomic DNA Translation: EAK3959197.1
AACFYK010000021 Genomic DNA Translation: EAK4052982.1
AACGHU010000003 Genomic DNA Translation: EAK4480133.1
AACGLD010000009 Genomic DNA Translation: EAK4636011.1
AACHDN010000006 Genomic DNA Translation: EAK5469164.1
AACHJB010000030 Genomic DNA Translation: EAK5720744.1
AACHRJ010000013 Genomic DNA Translation: EAK6096135.1
AACHVH010000024 Genomic DNA Translation: EAK6320999.1
AACHYE010000019 Genomic DNA Translation: EAK6413994.1
AACIPE010000006 Genomic DNA Translation: EAK7211494.1
AACJGP010000008 Genomic DNA Translation: EAK7994062.1
AACJHV010000006 Genomic DNA Translation: EAK8051354.1
AACJKU010000009 Genomic DNA Translation: EAK8190015.1
AACJMW010000007 Genomic DNA Translation: EAK8287710.1
AACLBB010000006 Genomic DNA Translation: EAL0602923.1
AACLVL010000026 Genomic DNA Translation: EAL1543760.1
AACNBI010000004 Genomic DNA Translation: EAL2988456.1
AACNNZ010000004 Genomic DNA Translation: EAL3555580.1
AACNRY010000014 Genomic DNA Translation: EAL3735632.1
AACRMJ010000020 Genomic DNA Translation: EAL8205092.1
AACRYE010000005 Genomic DNA Translation: EAL8746591.1
AACTBT010000020 Genomic DNA Translation: EAM0092426.1
AAHZZJ010000011 Genomic DNA Translation: ECC0801544.1
AAIALW010000006 Genomic DNA Translation: ECC1791147.1
AAIRNL010000006 Genomic DNA Translation: ECH3780522.1
AAKCHK010000002 Genomic DNA Translation: ECQ6180154.1
AAKETF010000028 Genomic DNA Translation: ECR1881583.1
AAKFAY010000029 Genomic DNA Translation: ECR2253670.1
AAKFEY010000034 Genomic DNA Translation: ECR2477572.1
AAKFNO010000002 Genomic DNA Translation: ECR3094804.1
AALBOD010000008 Genomic DNA Translation: ECX9710518.1
AALBQC010000005 Genomic DNA Translation: ECX9863142.1
AALFZE010000006 Genomic DNA Translation: ECZ0348327.1
AALEXQ010000007 Genomic DNA Translation: ECZ3289055.1
AAMHDU010000006 Genomic DNA Translation: EDH3141378.1
AAMHEJ010000032 Genomic DNA Translation: EDH3174060.1
AANCBJ010000005 Genomic DNA Translation: EDN6100379.1
AANHQX010000007 Genomic DNA Translation: EDO8327339.1
AANKYW010000006 Genomic DNA Translation: EDP3564293.1
AANMHR010000003 Genomic DNA Translation: EDP5150056.1
AANMNT010000027 Genomic DNA Translation: EDP5433018.1
AANNEJ010000001 Genomic DNA Translation: EDP6189175.1
AANNGO010000005 Genomic DNA Translation: EDP6286368.1
AANOHG010000005 Genomic DNA Translation: EDP7521668.1
AANOUA010000005 Genomic DNA Translation: EDP8179043.1
QELP01000005 Genomic DNA Translation: PVX09384.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B81250

NCBI Reference Sequences

More...
RefSeqi
WP_002851467.1, NZ_WSNU01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
PVX09384; PVX09384; DDV78_05225
SQA69095; SQA69095; NCTC13362_00195

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|197.5165.peg.1519

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486544 Genomic DNA Translation: AAM00822.1
AF486551 Genomic DNA Translation: AAM00854.1
AF486558 Genomic DNA Translation: AAM00889.1
AAAEXG010000023 Genomic DNA Translation: EAB5309620.1
AACBFH010000006 Genomic DNA Translation: EAJ8462090.1
AACFGQ010000019 Genomic DNA Translation: EAK3187109.1
AACFRH010000005 Genomic DNA Translation: EAK3705092.1
AACFRW010000010 Genomic DNA Translation: EAK3794915.1
AACFWJ010000004 Genomic DNA Translation: EAK3959197.1
AACFYK010000021 Genomic DNA Translation: EAK4052982.1
AACGHU010000003 Genomic DNA Translation: EAK4480133.1
AACGLD010000009 Genomic DNA Translation: EAK4636011.1
AACHDN010000006 Genomic DNA Translation: EAK5469164.1
AACHJB010000030 Genomic DNA Translation: EAK5720744.1
AACHRJ010000013 Genomic DNA Translation: EAK6096135.1
AACHVH010000024 Genomic DNA Translation: EAK6320999.1
AACHYE010000019 Genomic DNA Translation: EAK6413994.1
AACIPE010000006 Genomic DNA Translation: EAK7211494.1
AACJGP010000008 Genomic DNA Translation: EAK7994062.1
AACJHV010000006 Genomic DNA Translation: EAK8051354.1
AACJKU010000009 Genomic DNA Translation: EAK8190015.1
AACJMW010000007 Genomic DNA Translation: EAK8287710.1
AACLBB010000006 Genomic DNA Translation: EAL0602923.1
AACLVL010000026 Genomic DNA Translation: EAL1543760.1
AACNBI010000004 Genomic DNA Translation: EAL2988456.1
AACNNZ010000004 Genomic DNA Translation: EAL3555580.1
AACNRY010000014 Genomic DNA Translation: EAL3735632.1
AACRMJ010000020 Genomic DNA Translation: EAL8205092.1
AACRYE010000005 Genomic DNA Translation: EAL8746591.1
AACTBT010000020 Genomic DNA Translation: EAM0092426.1
AAHZZJ010000011 Genomic DNA Translation: ECC0801544.1
AAIALW010000006 Genomic DNA Translation: ECC1791147.1
AAIRNL010000006 Genomic DNA Translation: ECH3780522.1
AAKCHK010000002 Genomic DNA Translation: ECQ6180154.1
AAKETF010000028 Genomic DNA Translation: ECR1881583.1
AAKFAY010000029 Genomic DNA Translation: ECR2253670.1
AAKFEY010000034 Genomic DNA Translation: ECR2477572.1
AAKFNO010000002 Genomic DNA Translation: ECR3094804.1
AALBOD010000008 Genomic DNA Translation: ECX9710518.1
AALBQC010000005 Genomic DNA Translation: ECX9863142.1
AALFZE010000006 Genomic DNA Translation: ECZ0348327.1
AALEXQ010000007 Genomic DNA Translation: ECZ3289055.1
AAMHDU010000006 Genomic DNA Translation: EDH3141378.1
AAMHEJ010000032 Genomic DNA Translation: EDH3174060.1
AANCBJ010000005 Genomic DNA Translation: EDN6100379.1
AANHQX010000007 Genomic DNA Translation: EDO8327339.1
AANKYW010000006 Genomic DNA Translation: EDP3564293.1
AANMHR010000003 Genomic DNA Translation: EDP5150056.1
AANMNT010000027 Genomic DNA Translation: EDP5433018.1
AANNEJ010000001 Genomic DNA Translation: EDP6189175.1
AANNGO010000005 Genomic DNA Translation: EDP6286368.1
AANOHG010000005 Genomic DNA Translation: EDP7521668.1
AANOUA010000005 Genomic DNA Translation: EDP8179043.1
QELP01000005 Genomic DNA Translation: PVX09384.1
PIRiB81250
RefSeqiWP_002851467.1, NZ_WSNU01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

REBASEi6013, M.Cje43430ORFAP
6091, M.Cje1849ORFAP

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
905832

Genome annotation databases

EnsemblBacteriaiPVX09384; PVX09384; DDV78_05225
SQA69095; SQA69095; NCTC13362_00195
PATRICifig|197.5165.peg.1519

Family and domain databases

Gene3Di1.20.1260.30, 1 hit
InterProiView protein in InterPro
IPR022749, D12N6_MeTrfase_N
IPR038333, D12N6_MeTrfase_N_sf
IPR003356, DNA_methylase_A-5
IPR002052, DNA_methylase_N6_adenine_CS
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF12161, HsdM_N, 1 hit
PF02384, N6_Mtase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092, N6_MTASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7B7V5_CAMJU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7B7V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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