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Protein

Serine-rich adhesin for platelets

Gene

sraP

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich adhesin for platelets
Alternative name(s):
Staphylococcus aureus surface protein A
Gene namesi
Name:sraP
Synonyms:sasA
Ordered Locus Names:SA2447
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

  • cell wall ; Peptidoglycan-anchor
  • Note: Possibly exported by the accessory SecA2/SecY2 system. Anchored to the cell wall by sortase A (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002739301 – 2232Serine-rich adhesin for plateletsAdd BLAST2232
PropeptideiPRO_00002739312233 – 2271Removed by sortasePROSITE-ProRule annotationAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2232Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Post-translational modificationi

Proteolytically cleaved by a metalloprotease.By similarity
Glycosylated.By similarity

Keywords - PTMi

Peptidoglycan-anchor

Structurei

3D structure databases

ProteinModelPortaliQ7A362
SMRiQ7A362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2229 – 2233LPXTG sorting signalPROSITE-ProRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi97 – 743Thr-richAdd BLAST647
Compositional biasi752 – 2213Ser-richAdd BLAST1462

Sequence similaritiesi

Belongs to the SraP family.Curated

Phylogenomic databases

HOGENOMiHOG000280317
OMAiTKYPEDP

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015919 Cadherin-like
IPR013320 ConA-like_dom_sf
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR022263 KxYKxGKxW
PfamiView protein in Pfam
PF00746 Gram_pos_anchor, 1 hit
SUPFAMiSSF49313 SSF49313, 2 hits
SSF49899 SSF49899, 1 hit
TIGRFAMsiTIGR03715 KxYKxGKxW, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7A362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRQKAFHD SLANEKTRVR LYKSGKNWVK SGIKEIEMFK IMGLPFISHS
60 70 80 90 100
LVSQDNQSIS KKMTGYGLKT TAVIGGAFTV NMLHDQQAFA ASDAPLTSEL
110 120 130 140 150
NTQSETVGNQ NSTTIEASTS TADSTSVTKN SSSVQTSNSD TVSSEKSEKV
160 170 180 190 200
TSTTNSTSNQ QEKLTSTSES TSSKNTTSSS DTKSVASTSS TEQPINTSTN
210 220 230 240 250
QSTASNNTSQ STTPSSVNLN KTSTTSTSTA PVKLRTFSRL AMSTFASAAT
260 270 280 290 300
TTAVTANTIT VNKDNLKQYM TTSGNATYDQ STGIVTLTQD AYSQKGAITL
310 320 330 340 350
GTRIDSNKSF HFSGKVNLGN KYEGHGNGGD GIGFAFSPGV LGETGLNGAA
360 370 380 390 400
VGIGGLSNAF GFKLDTYHNT SKPNSAAKAN ADPSNVAGGG AFGAFVTTDS
410 420 430 440 450
YGVATTYTSS STADNAAKLN VQPTNNTFQD FDINYNGDTK VMTVKYAGQT
460 470 480 490 500
WTRNISDWIA KSGTTNFSLS MTASTGGATN LQQVQFGTFE YTESAVTQVR
510 520 530 540 550
YVDVTTGKDI IPPKTYSGNV DQVVTIDNQQ SALTAKGYNY TSVDSSYAST
560 570 580 590 600
YNDTNKTVKM TNAGQSVTYY FTDVKAPTVT VGNQTIEVGK TMNPVVLTTT
610 620 630 640 650
DNGTGTVTNT VTGLPSGLSY DSATNSIIGT PTKIGQSTVT VVSTDQANNK
660 670 680 690 700
STTTFTINVV DTTAPTVTPI GDQSSEVYSP ISPIKIATQD NSGNAVTNTV
710 720 730 740 750
TGLPSGLTFD STNNTISGTP TNIGTSTISI VSTDASGNKT TTTFKYEVTR
760 770 780 790 800
NSMSDSVSTS GSTQQSQSVS TSKADSQSAS TSTSGSIVVS TSASTSKSTS
810 820 830 840 850
VSLSDSVSAS KSLSTSESNS VSSSTSTSLV NSQSVSSSMS GSVSKSTSLS
860 870 880 890 900
DSISNSNSTE KSESLSTSTS DSLRTSTSLS DSLSMSTSGS LSKSQSLSTS
910 920 930 940 950
ISGSSSTSAS LSDSTSNAIS TSTSLSESAS TSDSISISNS IANSQSASTS
960 970 980 990 1000
KSDSQSTSIS LSTSDSKSMS TSESLSDSTS TSGSVSGSLS IAASQSVSTS
1010 1020 1030 1040 1050
TSDSMSTSEI VSDSISTSGS LSASDSKSMS VSSSMSTSQS GSTSESLSDS
1060 1070 1080 1090 1100
QSTSDSDSKS LSLSTSQSGS TSTSTSTSAS VRTSESQSTS GSMSASQSDS
1110 1120 1130 1140 1150
MSISTSFSDS TSDSKSASTA SSESISQSAS TSTSGSVSTS TSLSTSNSER
1160 1170 1180 1190 1200
TSTSVSDSTS LSTSESDSIS ESTSTSDSIS EAISASESTS ISLSESNSTS
1210 1220 1230 1240 1250
DSESQSASAF LSESLSESTS ESTSESVSSS TSESTSLSDS TSESGSTSTS
1260 1270 1280 1290 1300
LSNSTSGSAS ISTSTSISES TSTFKSESVS TSLSMSTSTS LSNSTSLSTS
1310 1320 1330 1340 1350
LSDSTSDSKS DSLSTSMSTS DSISTSKSDS ISTSTSLSGS TSESESDSTS
1360 1370 1380 1390 1400
SSESKSDSTS MSISMSQSTS GSTSTSTSTS LSDSTSTSLS LSASMNQSGV
1410 1420 1430 1440 1450
DSNSASQSAS NSTSTSTSES DSQSTSTYTS QSTSQSESTS TSTSLSDSTS
1460 1470 1480 1490 1500
ISKSTSQSGS TSTSASLSGS ESESDSQSIS TSASESTSES ASTSLSDSTS
1510 1520 1530 1540 1550
TSNSGSASTS TSLSNSASAS ESDSSSTSLS DSTSASMQSS ESDSQSTSAS
1560 1570 1580 1590 1600
LSDSLSTSTS NRMSTIASLS TSVSTSESGS TSESTSESDS TSTSLSDSQS
1610 1620 1630 1640 1650
TSRSTSASGS ASTSTSTSDS RSTSASTSTS MRTSTSDSQS MSLSTSTSTS
1660 1670 1680 1690 1700
MSDSTSLSDS VSDSTSDSTS ASTSGSMSVS ISLSDSTSTS TSASEVMSAS
1710 1720 1730 1740 1750
ISDSQSMSES VNDSESVSES NSESDSKSMS GSTSVSDSGS LSVSTSLRKS
1760 1770 1780 1790 1800
ESVSESSSLS GSQSMSDSVS TSDSSSLSVS TSLRSSESVS ESDSLSDSKS
1810 1820 1830 1840 1850
TSGSTSTSTS GSLSTSTSLS GSESVSESTS LSDSISMSDS TSTSDSDSLS
1860 1870 1880 1890 1900
GSISLSGSTS LSTSDSLSDS KSLSSSQSMS GSESTSTSVS DSQSSSTSNS
1910 1920 1930 1940 1950
QFDSMSISAS ESDSMSTSDS SNISGSNSTS TSLSTSDSMS GSVSVSTSTS
1960 1970 1980 1990 2000
LSDSISGSTS VSDSSSTSTS TSLSDSMSQS QSTSTSASGS LSTSISTSMS
2010 2020 2030 2040 2050
MSASTSSSQS TSVSTSLSTS DSISDSTSIS ISGSQSTVES ESTSDSTSIS
2060 2070 2080 2090 2100
DSESLSTSDS DSTSTSTSDS TSGSTSTSIS ESLSTSGSGS TSVSDSTSMS
2110 2120 2130 2140 2150
ESDSTSVSMS QDKSDSTSIS DSESVSTSTS TSLSTSDSTS TSESLSTSMS
2160 2170 2180 2190 2200
GSQSISDSTS TSMSGSTSTS ESNSMHPSDS MSMHHTHSTS TSRLSSEATT
2210 2220 2230 2240 2250
STSESQSTLS ATSEVTKHNG TPAQSEKRLP DTGDSIKQNG LLGGVMTLLV
2260 2270
GLGLMKRKKK KDENDQDDSQ A
Length:2,271
Mass (Da):227,848
Last modified:July 5, 2004 - v1
Checksum:i7C2A7040D6C8289D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB43752.1
PIRiF90073
RefSeqiWP_000044547.1, NC_002745.2

Genome annotation databases

EnsemblBacteriaiBAB43752; BAB43752; BAB43752
KEGGisau:SA2447

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB43752.1
PIRiF90073
RefSeqiWP_000044547.1, NC_002745.2

3D structure databases

ProteinModelPortaliQ7A362
SMRiQ7A362
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB43752; BAB43752; BAB43752
KEGGisau:SA2447

Phylogenomic databases

HOGENOMiHOG000280317
OMAiTKYPEDP

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015919 Cadherin-like
IPR013320 ConA-like_dom_sf
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR022263 KxYKxGKxW
PfamiView protein in Pfam
PF00746 Gram_pos_anchor, 1 hit
SUPFAMiSSF49313 SSF49313, 2 hits
SSF49899 SSF49899, 1 hit
TIGRFAMsiTIGR03715 KxYKxGKxW, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRAP_STAAN
AccessioniPrimary (citable) accession number: Q7A362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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