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Protein

Circadian clock protein KaiA

Gene

kaiA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.4 Publications

Miscellaneous

'Kai' means 'cycle' in Japanese.

Caution

PubMed:15007067 structure is derived from this sequence and not from the one of S.elongatus.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • circadian rhythm Source: InterPro
  • entrainment of circadian clock Source: UniProtKB
  • negative regulation of protein dephosphorylation Source: CACAO
  • positive regulation of circadian rhythm Source: UniProtKB
  • protein phosphorylation Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SYNEL:SYNPCC7942_1218-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Circadian clock protein KaiA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kaiA
Ordered Locus Names:Synpcc7942_1218
ORF Names:see0009
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1140 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002717 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9I → T: Extends the period of the circadian rhythm to 29 hours. 1 Publication1
Mutagenesisi16I → F: Extends the period of the circadian rhythm to 27 hours. 1 Publication1
Mutagenesisi31L → P: Extends the period of the circadian rhythm to 27 hours. 1 Publication1
Mutagenesisi36S → P: Extends the period of the circadian rhythm to 29 hours. 1 Publication1
Mutagenesisi53C → S: Induces an arrhythmic phenotype. 1 Publication1
Mutagenesisi76V → G: Extends the period of the circadian rhythm to 28 hours. 1 Publication1
Mutagenesisi103E → K in kaiA1; extends the period of the circadian rhythm to 33 hours and increases the interaction with KaiB. 1
Mutagenesisi113Q → R: Extends the period of the circadian rhythm to 33 hours. 1 Publication1
Mutagenesisi117Q → L: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi119D → E: Extends the period of the circadian rhythm to 30 hours. 1 Publication1
Mutagenesisi119D → G: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi131V → A: Extends the period of the circadian rhythm to 28 hours. 1 Publication1
Mutagenesisi136D → V: Extends the period of the circadian rhythm to 30 hours. 1 Publication1
Mutagenesisi136D → Y: Extends the period of the circadian rhythm to 29 hours. 1 Publication1
Mutagenesisi166Y → C in kaiA3; induces an arrhythmic phenotype and reduces the interaction with KaiC. 1
Mutagenesisi178F → S or I: Induces an arrhythmic phenotype. 1 Publication1
Mutagenesisi180R → H: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi194M → T: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi224F → S: Induces an arrhythmic phenotype. 1 Publication1
Mutagenesisi225F → S: Induces an arrhythmic phenotype. 1 Publication1
Mutagenesisi239E → G: Extends the period of the circadian rhythm to 28 hours. 1 Publication1
Mutagenesisi241M → T: Extends the period of the circadian rhythm to 38 hours. 1 Publication1
Mutagenesisi242D → V or G: Extends the period of the circadian rhythm to 27 hours. 1 Publication1
Mutagenesisi243E → A: Extends the period of the circadian rhythm to 34 hours. 1 Publication1
Mutagenesisi244F → V: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi245A → D: Extends the period of the circadian rhythm to 26 hours. 1 Publication1
Mutagenesisi249R → H in kaiA1; extends the period of the circadian rhythm to 30 hours. 1
Mutagenesisi266I → V: Extends the period of the circadian rhythm to 27 hours. 1 Publication1
Mutagenesisi273C → Y: Extends the period of the circadian rhythm to 30 hours. 1 Publication1
Mutagenesisi274E → K in kaiA3; induces an arrhythmic phenotype. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002178711 – 284Circadian clock protein KaiAAdd BLAST284

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q79PF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed constantly throughout the circadian cycle.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. The KaiABC complex also interacts with SasA.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-33329N

Protein interaction database and analysis system

More...
IntActi
Q79PF6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
1140.Synpcc7942_1218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q79PF6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q79PF6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q79PF6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 164KaiA N-terminalPROSITE-ProRule annotationAdd BLAST164
Domaini174 – 282KaiA C-terminalPROSITE-ProRule annotationAdd BLAST109

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal part (1-102), which is also called pseudo-receiver domain, does not enhance KaiC autophosphorylation. It may have an amplitude-amplifier function and may be involved in transducing input signals to the KaiABC complex. This domain is not conserved in other species.1 Publication
The KaiA domain mediates the interaction with KaiC, the homodimerization, and is responsible for the clock oscillation function.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108WXF Bacteria
ENOG410YS5X LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276784

KEGG Orthology (KO)

More...
KOi
K08480

Database of Orthologous Groups

More...
OrthoDBi
POG091H10AH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1240.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011006 CheY-like_superfamily
IPR011648 Circadian_clock_KaiA
IPR020844 Circadian_clock_KaiA_N
IPR020856 Circadian_clock_protein_KaiA_C
IPR017944 KaiA/RbsU_helical_domain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07688 KaiA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01247 KaiA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101215 SSF101215, 1 hit
SSF52172 SSF52172, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51431 KAIA_C, 1 hit
PS51430 KAIA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q79PF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSQIAICIW VESTAILQDC QRALSADRYQ LQVCESGEML LEYAQTHRDQ
60 70 80 90 100
IDCLILVAAN PSFRAVVQQL CFEGVVVPAI VVGDRDSEDP DEPAKEQLYH
110 120 130 140 150
SAELHLGIHQ LEQLPYQVDA ALAEFLRLAP VETMADHIML MGANHDPELS
160 170 180 190 200
SQQRDLAQRL QERLGYLGVY YKRDPDRFLR NLPAYESQKL HQAMQTSYRE
210 220 230 240 250
IVLSYFSPNS NLNQSIDNFV NMAFFADVPV TKVVEIHMEL MDEFAKKLRV
260 270 280
EGRSEDILLD YRLTLIDVIA HLCEMYRRSI PRET
Length:284
Mass (Da):32,632
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C4F3B79FFDF59A2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB010691 Genomic DNA Translation: BAA37101.1
AY120853 Genomic DNA Translation: AAM82684.1
CP000100 Genomic DNA Translation: ABB57248.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T44267

NCBI Reference Sequences

More...
RefSeqi
WP_011377921.1, NC_007604.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABB57248; ABB57248; Synpcc7942_1218

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
syf:Synpcc7942_1218

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010691 Genomic DNA Translation: BAA37101.1
AY120853 Genomic DNA Translation: AAM82684.1
CP000100 Genomic DNA Translation: ABB57248.1
PIRiT44267
RefSeqiWP_011377921.1, NC_007604.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M2ENMR-A1-135[»]
1M2FNMR-A1-135[»]
1R8JX-ray2.03A/B2-284[»]
4G86X-ray2.39A/B2-284[»]
5C5EX-ray2.82A/B1-284[»]
5N8Yelectron microscopy4.70M/N/O/P/Q/R/S/T/U/V/W/X1-284[»]
ProteinModelPortaliQ79PF6
SMRiQ79PF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-33329N
IntActiQ79PF6, 4 interactors
STRINGi1140.Synpcc7942_1218

Proteomic databases

PRIDEiQ79PF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB57248; ABB57248; Synpcc7942_1218
KEGGisyf:Synpcc7942_1218

Phylogenomic databases

eggNOGiENOG4108WXF Bacteria
ENOG410YS5X LUCA
HOGENOMiHOG000276784
KOiK08480
OrthoDBiPOG091H10AH

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1218-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ79PF6

Family and domain databases

Gene3Di1.10.1240.30, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR011648 Circadian_clock_KaiA
IPR020844 Circadian_clock_KaiA_N
IPR020856 Circadian_clock_protein_KaiA_C
IPR017944 KaiA/RbsU_helical_domain_sf
PfamiView protein in Pfam
PF07688 KaiA, 1 hit
SMARTiView protein in SMART
SM01247 KaiA, 1 hit
SUPFAMiSSF101215 SSF101215, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51431 KAIA_C, 1 hit
PS51430 KAIA_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAIA_SYNE7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q79PF6
Secondary accession number(s): Q31NX1, Q9Z3H4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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