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Entry version 85 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

PPE family protein PPE34

Gene

PPE34

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL-4, IL-5 and IL-10 from CD4+ T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-kappa-B signaling pathways.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-6114-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PPE family protein PPE34Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPE34Imported
Ordered Locus Names:Rv1917cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1917c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004379391 – 1459PPE family protein PPE34Add BLAST1459

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q79FI9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with human TLR2.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1917c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q79FI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 193Ala-richPROSITE-ProRule annotationAdd BLAST168

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PPE family.Curated

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
ANRMIST

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q79FI9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1260.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002989 Mycobac_pentapep
IPR000030 PPE_family
IPR038332 PPE_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01469 Pentapeptide_2, 10 hits
PF00823 PPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q79FI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSTLPPEI NSALIFGGAG SEPMSAAAVA WDQLAMELAS AAASFNSVTS
60 70 80 90 100
GLVGESWLGP SSAAMAAAVA PYLGWLAAAA AQAQRSATQA AALVAEFEAV
110 120 130 140 150
RAAMVQPALV AANRSDLVSL VFSNFFGQNA PAIAAIEAAY EQMWAIDVSV
160 170 180 190 200
MSAYHAGASA VASALTPFTA PPQNLTDLPA QLAAAPAAVV TAAITSSKGV
210 220 230 240 250
LANLSLGLAN SGFGQMGAAN LGILNLGSLN PGGNNFGLGN VGSNNVGLGN
260 270 280 290 300
TGNGNIGFGN TGNGNIGFGL TGDNQQGFGG WNSGTGNIGL FNSGTGNIGI
310 320 330 340 350
GNTGTGNFGI GNSGTSYNTG IGNTGQANTG FFNAGIANTG IGNTGNYNTG
360 370 380 390 400
SFNLGSFNTG DFNTGSSNTG FFNPGNLNTG VGNTGNVNTG GFNSGNYSNG
410 420 430 440 450
FFWRGDYQGL IGFSGTLTIP AAGLDLNGLG SVGPITIPSI TIPEIGLGIN
460 470 480 490 500
SSGALVGPIN VPPITVPAIG LGINSTGALV GPINIPPITL NSIGLELSAF
510 520 530 540 550
QVINVGSISI PASPLAIGLF GVNPTVGSIG PGSISIQLGT PEIPAIPPFF
560 570 580 590 600
PGFPPDYVTV SGQIGPITFL SGGYSLPAIP LGIDVGGGLG PFTVFPDGYS
610 620 630 640 650
LPAIPLGIDV GGGLGPFTVF PDGYSLPAIP LGIDVGGGLG PFTVFPDGYS
660 670 680 690 700
LPAIPLGIDV GGAIGPLTTP PITIPSIPLG IDVSGSLGPI NIPIEIAGTP
710 720 730 740 750
GFGNSTTTPS SGFFNSGTGG TSGFGNVGSG GSGFWNIAGN LGNSGFLNVG
760 770 780 790 800
PLTSGILNFG NTVSGLYNTS TLGLATSAFH SGVGNTDSQL AGFMRNAAGG
810 820 830 840 850
TLFNFGFAND GTLNLGNANL GDYNVGSGNV GSYNFGSGNI GNGSFGFGNI
860 870 880 890 900
GSNNFGFGNV GSNNLGFANT GPGLTEALHN IGFGNIGGNN YGFANIGNGN
910 920 930 940 950
IGFGNTGTGN IGIGLTGDNQ VGFGALNSGS GNIGFFNSGN GNIGFFNSGN
960 970 980 990 1000
GNVGIGNSGN YNTGLGNVGN ANTGLFNTGN VNTGIGNAGS YNTGSYNAGD
1010 1020 1030 1040 1050
TNTGDLNPGN ANTGYLNLGD LNTGWGNIGD LNTGALISGS YSNGILWRGD
1060 1070 1080 1090 1100
YQGLIGYSDT LSIPAIPLSV EVNGGIGPIV VPDITIPGIP LSLNALGGVG
1110 1120 1130 1140 1150
PIVVPDITIP GIPLSLNALG GVGPIVVPDI TIPGIPLSLN ALGGVGPIVV
1160 1170 1180 1190 1200
PDITIPGIPL SLNALGGVGP IVVPDITIPG IPLSLNALGG VGPITVPGVP
1210 1220 1230 1240 1250
ISRIPLTINI RIPVNITLNE LPFNVAGIFT GYIGPIPLST FVLGVTLAGG
1260 1270 1280 1290 1300
TLESGIQGFS VNPFGLNIPL SGATNAVTIP GFAINPFGLN VPLSGGTSPV
1310 1320 1330 1340 1350
TIPGFAINPF GLNVPLSGGT SPVTIPGFTI PGSPLNLTAN GGLGPINIPI
1360 1370 1380 1390 1400
NITSAPGFGN STTTPSSGFF NSGDGSASGF GNVGPGISGL WNQVPNALQG
1410 1420 1430 1440 1450
GVSGIYNVGQ LASGVANLGN TVSGFNNTST VGHLTAAFNS GVNNIGQMLL

GFFSPGAGP
Length:1,459
Mass (Da):142,944
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i174F54ED439B579E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44684.1

NCBI Reference Sequences

More...
RefSeqi
WP_010886134.1, NC_018143.2
YP_177655.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44684; CCP44684; Rv1917c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
885362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1917c
mtv:RVBD_1917c

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.111.peg.2132

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44684.1
RefSeqiWP_010886134.1, NC_018143.2
YP_177655.1, NC_000962.3

3D structure databases

SMRiQ79FI9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1917c

Proteomic databases

PaxDbiQ79FI9

Genome annotation databases

EnsemblBacteriaiCCP44684; CCP44684; Rv1917c
GeneIDi885362
KEGGimtu:Rv1917c
mtv:RVBD_1917c
PATRICifig|83332.111.peg.2132

Organism-specific databases

TubercuListiRv1917c

Phylogenomic databases

OMAiANRMIST
PhylomeDBiQ79FI9

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-6114-MONOMER

Family and domain databases

Gene3Di1.20.1260.20, 1 hit
InterProiView protein in InterPro
IPR002989 Mycobac_pentapep
IPR000030 PPE_family
IPR038332 PPE_sf
PfamiView protein in Pfam
PF01469 Pentapeptide_2, 10 hits
PF00823 PPE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPE34_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q79FI9
Secondary accession number(s): I6XCU7, L0TAZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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