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Protein

Beta-lactamase

Gene

blaTEM-116

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS11.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaTEM-116Imported
Synonyms:blaImported, blaTEMImported
ORF Names:AKG99_27490Imported
Encoded oniPlasmid TEMImported
Plasmid pAm05WL3325Imported
Plasmid pAm05WL6211Imported
Plasmid pAm08CQ3205Imported
Plasmid pAm08WL3069Imported
Plasmid pCAPsImported
Plasmid pEPEC105Imported
Plasmid pEPEC121Imported
Plasmid pEPEC239Imported
Plasmid pRP4Imported
Plasmid unnamedImported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000036728 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501529891824 – 286Beta-lactamaseSequence analysisAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 121Combined sources

Structurei

3D structure databases

SMRiQ79DR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK18698

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Q79DR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN
60 70 80 90 100
SGKILESFRP EERFPMMSTF KVLLCGAVLS RIDAGQEQLG RRIHYSQNDL
110 120 130 140 150
VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL
160 170 180 190 200
HNMGDHVTRL DRWEPELNEA IPNDERDTTM PVAMATTLRK LLTGELLTLA
210 220 230 240 250
SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD
260 270 280
GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW
Length:286
Mass (Da):31,557
Last modified:July 5, 2004 - v1
Checksum:i5EB2F22753375FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74750 Genomic DNA Translation: AAA24057.1
AY425988 Genomic DNA Translation: AAQ95605.1
EF144117 Genomic DNA Translation: ABL76153.1
EF198754 Genomic DNA Translation: ABM81536.1
EF198755 Genomic DNA Translation: ABM81537.1
GQ149342 Genomic DNA Translation: ADA79624.1
GQ149343 Genomic DNA Translation: ADA79628.1
GQ149346 Genomic DNA Translation: ADA79629.1
GQ149348 Genomic DNA Translation: ADA79634.1
JN188365 Genomic DNA Translation: AEP25421.1
KJ923003 Genomic DNA Translation: AIL92158.1
KJ923005 Genomic DNA Translation: AIL92160.1
KJ923006 Genomic DNA Translation: AIL92161.1
KJ923008 Genomic DNA Translation: AIL92163.1
KJ923009 Genomic DNA Translation: AIL92164.1
KJ939551 Genomic DNA Translation: AIO04203.1
KJ939553 Genomic DNA Translation: AIO04205.1
KJ939554 Genomic DNA Translation: AIO04206.1
KJ939555 Genomic DNA Translation: AIO04207.1
KJ939556 Genomic DNA Translation: AIO04208.1
KJ939557 Genomic DNA Translation: AIO04209.1
KJ939558 Genomic DNA Translation: AIO04210.1
KJ939559 Genomic DNA Translation: AIO04211.1
KM873145 Genomic DNA Translation: AJA90839.1
KM873147 Genomic DNA Translation: AJA90841.1
KM873148 Genomic DNA Translation: AJA90842.1
KM593700 Genomic DNA Translation: AJA90870.1
KM593704 Genomic DNA Translation: AJA90874.1
KM593706 Genomic DNA Translation: AJA90876.1
KY466954 Genomic DNA Translation: ASF87079.1
KY466955 Genomic DNA Translation: ASF87080.1
KY466958 Genomic DNA Translation: ASF87083.1
KY466959 Genomic DNA Translation: ASF87084.1
KY466960 Genomic DNA Translation: ASF87085.1
KY466961 Genomic DNA Translation: ASF87086.1
KY466964 Genomic DNA Translation: ASF87089.1
KY466965 Genomic DNA Translation: ASF87090.1
KY466966 Genomic DNA Translation: ASF87091.1
KY466967 Genomic DNA Translation: ASF87092.1
KY466969 Genomic DNA Translation: ASF87094.1
AJ001614 Genomic DNA Translation: CAA04868.1
Y12694 Genomic DNA Translation: CAA73226.1
AJ847362 Genomic DNA Translation: CAH60311.1
AJ847363 Genomic DNA Translation: CAH60312.1
AJ847364 Genomic DNA Translation: CAH60313.1
LHAT01000193 Genomic DNA Translation: KNZ95924.1
RefSeqiWP_000027050.1, NZ_PJRM01000091.1
YP_006952154.1, NC_019050.1
YP_006952158.1, NC_019051.1
YP_006952163.1, NC_019053.1
YP_006952279.1, NC_019058.1
YP_009062843.1, NC_025010.1
YP_009071409.1, NC_025181.1

Genome annotation databases

EnsemblBacteriaiKNZ95924; KNZ95924; AKG99_27490
GeneIDi13909503
13909507
13909515
13909536
20468887
KEGGiag:AAQ95605
PATRICifig|562.7439.peg.2148

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74750 Genomic DNA Translation: AAA24057.1
AY425988 Genomic DNA Translation: AAQ95605.1
EF144117 Genomic DNA Translation: ABL76153.1
EF198754 Genomic DNA Translation: ABM81536.1
EF198755 Genomic DNA Translation: ABM81537.1
GQ149342 Genomic DNA Translation: ADA79624.1
GQ149343 Genomic DNA Translation: ADA79628.1
GQ149346 Genomic DNA Translation: ADA79629.1
GQ149348 Genomic DNA Translation: ADA79634.1
JN188365 Genomic DNA Translation: AEP25421.1
KJ923003 Genomic DNA Translation: AIL92158.1
KJ923005 Genomic DNA Translation: AIL92160.1
KJ923006 Genomic DNA Translation: AIL92161.1
KJ923008 Genomic DNA Translation: AIL92163.1
KJ923009 Genomic DNA Translation: AIL92164.1
KJ939551 Genomic DNA Translation: AIO04203.1
KJ939553 Genomic DNA Translation: AIO04205.1
KJ939554 Genomic DNA Translation: AIO04206.1
KJ939555 Genomic DNA Translation: AIO04207.1
KJ939556 Genomic DNA Translation: AIO04208.1
KJ939557 Genomic DNA Translation: AIO04209.1
KJ939558 Genomic DNA Translation: AIO04210.1
KJ939559 Genomic DNA Translation: AIO04211.1
KM873145 Genomic DNA Translation: AJA90839.1
KM873147 Genomic DNA Translation: AJA90841.1
KM873148 Genomic DNA Translation: AJA90842.1
KM593700 Genomic DNA Translation: AJA90870.1
KM593704 Genomic DNA Translation: AJA90874.1
KM593706 Genomic DNA Translation: AJA90876.1
KY466954 Genomic DNA Translation: ASF87079.1
KY466955 Genomic DNA Translation: ASF87080.1
KY466958 Genomic DNA Translation: ASF87083.1
KY466959 Genomic DNA Translation: ASF87084.1
KY466960 Genomic DNA Translation: ASF87085.1
KY466961 Genomic DNA Translation: ASF87086.1
KY466964 Genomic DNA Translation: ASF87089.1
KY466965 Genomic DNA Translation: ASF87090.1
KY466966 Genomic DNA Translation: ASF87091.1
KY466967 Genomic DNA Translation: ASF87092.1
KY466969 Genomic DNA Translation: ASF87094.1
AJ001614 Genomic DNA Translation: CAA04868.1
Y12694 Genomic DNA Translation: CAA73226.1
AJ847362 Genomic DNA Translation: CAH60311.1
AJ847363 Genomic DNA Translation: CAH60312.1
AJ847364 Genomic DNA Translation: CAH60313.1
LHAT01000193 Genomic DNA Translation: KNZ95924.1
RefSeqiWP_000027050.1, NZ_PJRM01000091.1
YP_006952154.1, NC_019050.1
YP_006952158.1, NC_019051.1
YP_006952163.1, NC_019053.1
YP_006952279.1, NC_019058.1
YP_009062843.1, NC_025010.1
YP_009071409.1, NC_025181.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OQGX-ray2.40A/B/C/D/E/F24-286[»]
SMRiQ79DR3
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS11.A01

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKNZ95924; KNZ95924; AKG99_27490
GeneIDi13909503
13909507
13909515
13909536
20468887
KEGGiag:AAQ95605
PATRICifig|562.7439.peg.2148

Phylogenomic databases

KOiK18698

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ79DR3_ECOLX
AccessioniPrimary (citable) accession number: Q79DR3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported, PlasmidImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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