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Entry version 107 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Putative formate dehydrogenase YrhE

Gene

yrhE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi39Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi50Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi53Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi65Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi97Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi101Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi104Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi111Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi153Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi156Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi159Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi163Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi196Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi199Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi202Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi206Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi270Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi273Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi277Iron-sulfur 5 (4Fe-4S)By similarity1
Metal bindingi305Iron-sulfur 5 (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU27220-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative formate dehydrogenase YrhE (EC:1.17.1.9)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yrhE
Ordered Locus Names:BSU27220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003606891 – 980Putative formate dehydrogenase YrhEAdd BLAST980

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q795Y4

PRoteomics IDEntifications database

More...
PRIDEi
Q795Y4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU27220

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q795Y4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 812Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77
Domaini81 – 1214Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST41
Domaini144 – 1714Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini187 – 2164Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini263 – 3194Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni258 – 980Formate dehydrogenaseBy similarityAdd BLAST723

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108JB9 Bacteria
COG3383 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031440

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q795Y4

KEGG Orthology (KO)

More...
KOi
K00123

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGTPTMH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q795Y4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00207 fer2, 1 hit
cd02753 MopB_Formate-Dh-H, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009010 Asp_de-COase-like_dom_sf
IPR041924 Formate_Dh-H_N
IPR006478 Formate_DH_asu
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12838 Fer4_7, 1 hit
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01591 Fdh-alpha, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q795Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDVKSISVR VDGTEIQARA GATILDILNE NGIEYPQICH VPEVDPIQTC
60 70 80 90 100
DTCIVEANGK LVRSCATVAE NGMSIDLSGN RVKEAQTEAM DRLLENHLLY
110 120 130 140 150
CTVCDNNNGN CTLHNTAEMM GIEHQKYPYT PKEDPSCAVD MSHPFYRYDP
160 170 180 190 200
NQCIACGQCV EVCQNLQVNE TLSIDWERER PRVIWDEGVP INESSCVSCG
210 220 230 240 250
QCVTVCPCNA LMEKSMLGQA GFMTGIKEDV MEPMIDLVKN VEPGYGSIFA
260 270 280 290 300
ISEVEAAMRE TRTKKTKTVC TFCGVGCSFE VWTKGRDILK IQPVSDAPVN
310 320 330 340 350
AISTCVKGKF GWDFVNSKER ITKPLIRKNG AFVESSWEEA LDLVASRLGS
360 370 380 390 400
IKEQYGKGSV GFISSSKITN EENYVIQKLA RQVFETNNVD NCSRYCQSPA
410 420 430 440 450
TDGLFRTVGM GGDAGTIKDI AKAGLVIIVG ANPAEGHPVL ATRVKRAHKL
460 470 480 490 500
HGQKLIVADL RKNEMAERSD LFISPKQGTD QVWLMAVTKY MIDQGWHDQA
510 520 530 540 550
FIDENVNYFE DYKETLKTYT LDYAERITGL SKENIIQIAE MIRDADGTCV
560 570 580 590 600
LWGMGVTQNT GGSDTSAAIS NLLLATGNYR RPGAGAYPLR GHNNVQGACD
610 620 630 640 650
MGTLPGWLPG YQHITDDKAR AKFEEAYGVE IDGKPGLDNI QMLHAIEEGK
660 670 680 690 700
MKAMYLVGED MALVDSNANH VHDILSSLDF FVVQDIFLSR TAQYADVVLP
710 720 730 740 750
ATPSLEKDGT FTNTERRVQR LYQALPTLGD AKPDWWIIQE VANRLGANWN
760 770 780 790 800
YSHPSDIFSE MASLSPLFAK ASYEVLEGWN SFLWGSFTGE STPLLYEDGF
810 820 830 840 850
NFPDKKARFA LSDWTEPAAF PEEYDLHINN GRMLEHFHEG NMTNKSKGIQ
860 870 880 890 900
AKVPNVFVEI SPELAQERGV CDGSLVRLVS PFGAVKLNAL ITDRVRKNEL
910 920 930 940 950
YLPMNSTDKE SAINFLTGPA ADKRTNTPAY KQTKVRMEVL GGCETAPLPK
960 970 980
TNPRNKKRHP QNGVEAERKW NRPGYVHLTD
Length:980
Mass (Da):108,775
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DA2B17A506806ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB14664.1

NCBI Reference Sequences

More...
RefSeqi
NP_390600.1, NC_000964.3
WP_010886582.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14664; CAB14664; BSU27220

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU27220

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.43.peg.2839

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB14664.1
RefSeqiNP_390600.1, NC_000964.3
WP_010886582.1, NZ_JNCM01000036.1

3D structure databases

SMRiQ795Y4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU27220

Proteomic databases

PaxDbiQ795Y4
PRIDEiQ795Y4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14664; CAB14664; BSU27220
GeneIDi937569
KEGGibsu:BSU27220
PATRICifig|224308.43.peg.2839

Phylogenomic databases

eggNOGiENOG4108JB9 Bacteria
COG3383 LUCA
HOGENOMiHOG000031440
InParanoidiQ795Y4
KOiK00123
OMAiDGTPTMH
PhylomeDBiQ795Y4

Enzyme and pathway databases

BioCyciBSUB:BSU27220-MONOMER

Family and domain databases

CDDicd00207 fer2, 1 hit
cd02753 MopB_Formate-Dh-H, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR009010 Asp_de-COase-like_dom_sf
IPR041924 Formate_Dh-H_N
IPR006478 Formate_DH_asu
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
PF10588 NADH-G_4Fe-4S_3, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SM00929 NADH-G_4Fe-4S_3, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR01591 Fdh-alpha, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS51839 4FE4S_HC3, 1 hit
PS51669 4FE4S_MOW_BIS_MGD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFDHL_BACSU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q795Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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