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Protein

Heterogeneous nuclear ribonucleoprotein F

Gene

Hnrnpf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).By similarity

GO - Molecular functioni

  • single-stranded RNA binding Source: UniProtKB
  • TBP-class protein binding Source: RGD
  • transcription factor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-6803529 FGFR2 alternative splicing
R-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein F
Short name:
hnRNP F
Cleaved into the following chain:
Gene namesi
Name:Hnrnpf
Synonyms:Hnrpf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620366 Hnrnpf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530541 – 415Heterogeneous nuclear ribonucleoprotein FAdd BLAST415
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003671172 – 415Heterogeneous nuclear ribonucleoprotein F, N-terminally processedAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F, N-terminally processedBy similarity1
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei104PhosphoserineCombined sources1
Modified residuei107PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei187PhosphoserineBy similarity1
Modified residuei193PhosphoserineBy similarity1
Modified residuei195PhosphoserineCombined sources1
Modified residuei200N6-acetyllysine; alternateBy similarity1
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei215PhosphothreonineBy similarity1
Modified residuei224N6-acetyllysine; alternateBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei265PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ794E4
PRIDEiQ794E4

PTM databases

iPTMnetiQ794E4
PhosphoSitePlusiQ794E4

Expressioni

Tissue specificityi

Detected in liver, thymus, spleen and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000014562 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiQ794E4 RN

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei16Interaction with RNABy similarity1
Sitei20Interaction with RNABy similarity1
Sitei52Interaction with RNABy similarity1
Sitei75Interaction with RNABy similarity1
Sitei116Interaction with RNABy similarity1
Sitei120Interaction with RNABy similarity1
Sitei150Interaction with RNABy similarity1
Sitei173Interaction with RNABy similarity1
Sitei294Interaction with RNABy similarity1
Sitei298Interaction with RNABy similarity1
Sitei326Interaction with RNABy similarity1
Sitei349Interaction with RNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249006, 2 interactors
IntActiQ794E4, 1 interactor
STRINGi10116.ENSRNOP00000019529

Structurei

3D structure databases

ProteinModelPortaliQ794E4
SMRiQ794E4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini289 – 366RRM 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 86Interaction with RNABy similarity6
Regioni179 – 184Interaction with RNABy similarity6
Regioni355 – 360Interaction with RNABy similarity6

Domaini

The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiQ794E4
KOiK12898
OMAiFLSECKI
PhylomeDBiQ794E4
TreeFamiTF316157

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q794E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLGPEGGEG YVVKLRGLPW SCSIEDVQNF LSDCTIHDGV AGVHFIYTRE
60 70 80 90 100
GRQSGEAFVE LESEDDVKLA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS
110 120 130 140 150
GPNSADSAND GFVRLRGLPF GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK
160 170 180 190 200
ITGEAFVQFA SQELAEKALG KHKERIGHRY IEVFKSSQEE VRSYSDPPLK
210 220 230 240 250
FMSVQRPGPY DRPGTARRYI GIVKQAGLDR MRSGAYSAGY GGYEEYSGLS
260 270 280 290 300
DGYGFTTDLF GRDLSYCLSG MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHEE AVAAMSKDRA
360 370 380 390 400
NMQHRYIELF LNSTTGASNG AYSSQVMQGM GVSAAQATYS GLESQSVSGC
410
YGAGYSGQNS MGGYD
Length:415
Mass (Da):45,730
Last modified:January 23, 2007 - v3
Checksum:i31E1C9C90A8E051F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022209 mRNA Translation: BAA37095.1
BC097275 mRNA Translation: AAH97275.1
BC103634 mRNA Translation: AAI03635.1
RefSeqiNP_001032362.1, NM_001037285.1
NP_001032363.1, NM_001037286.1
NP_001032364.1, NM_001037287.1
NP_071792.1, NM_022397.3
XP_008761484.1, XM_008763262.2
XP_017448358.1, XM_017592869.1
XP_017448359.1, XM_017592870.1
XP_017448360.1, XM_017592871.1
XP_017448361.1, XM_017592872.1
XP_017448362.1, XM_017592873.1
XP_017448363.1, XM_017592874.1
XP_017448364.1, XM_017592875.1
UniGeneiRn.144596

Genome annotation databases

EnsembliENSRNOT00000019529; ENSRNOP00000019529; ENSRNOG00000014562
ENSRNOT00000083843; ENSRNOP00000068652; ENSRNOG00000014562
ENSRNOT00000091765; ENSRNOP00000069655; ENSRNOG00000014562
GeneIDi64200
KEGGirno:64200
UCSCiRGD:620366 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022209 mRNA Translation: BAA37095.1
BC097275 mRNA Translation: AAH97275.1
BC103634 mRNA Translation: AAI03635.1
RefSeqiNP_001032362.1, NM_001037285.1
NP_001032363.1, NM_001037286.1
NP_001032364.1, NM_001037287.1
NP_071792.1, NM_022397.3
XP_008761484.1, XM_008763262.2
XP_017448358.1, XM_017592869.1
XP_017448359.1, XM_017592870.1
XP_017448360.1, XM_017592871.1
XP_017448361.1, XM_017592872.1
XP_017448362.1, XM_017592873.1
XP_017448363.1, XM_017592874.1
XP_017448364.1, XM_017592875.1
UniGeneiRn.144596

3D structure databases

ProteinModelPortaliQ794E4
SMRiQ794E4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249006, 2 interactors
IntActiQ794E4, 1 interactor
STRINGi10116.ENSRNOP00000019529

PTM databases

iPTMnetiQ794E4
PhosphoSitePlusiQ794E4

Proteomic databases

PaxDbiQ794E4
PRIDEiQ794E4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019529; ENSRNOP00000019529; ENSRNOG00000014562
ENSRNOT00000083843; ENSRNOP00000068652; ENSRNOG00000014562
ENSRNOT00000091765; ENSRNOP00000069655; ENSRNOG00000014562
GeneIDi64200
KEGGirno:64200
UCSCiRGD:620366 rat

Organism-specific databases

CTDi3185
RGDi620366 Hnrnpf

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiQ794E4
KOiK12898
OMAiFLSECKI
PhylomeDBiQ794E4
TreeFamiTF316157

Enzyme and pathway databases

ReactomeiR-RNO-6803529 FGFR2 alternative splicing
R-RNO-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q794E4

Gene expression databases

BgeeiENSRNOG00000014562 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiQ794E4 RN

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPF_RAT
AccessioniPrimary (citable) accession number: Q794E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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