Neuroendocrine secretory protein 55

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-tubulin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells."
    Montoya V., Gutierrez C., Najera O., Leony D., Varela-Ramirez A., Popova J., Rasenick M.M., Das S., Roychowdhury S.
    Cell Motil Cytoskeleton 64:936-950(2007) [PubMed] [Europe PMC] [Abstract]
• beta-2 adrenergic receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• corticotropin-releasing hormone receptor 1 binding Source: RGDInferred from physical interactionⁱ
  • "Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology."
    Bangasser D.A., Curtis A., Reyes B.A., Bethea T.T., Parastatidis I., Ischiropoulos H., Van Bockstaele E.J., Valentino R.J.
    Mol Psychiatry 15:877, 2010:896-904(2010) [PubMed] [Europe PMC] [Abstract]
• D1 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am J Physiol Renal Physiol 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Two overlapping reading frames in a single exon encode interacting proteins -- a novel way of gene usage."
    Klemke M., Kehlenbach R.H., Huttner W.B.
    EMBO J. 20:3849-3860(2001) [PubMed] [Europe PMC] [Abstract]
• G-protein beta/gamma-subunit complex binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G-protein beta-subunit binding Source: RGDInferred from direct assayⁱ
  • "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells."
    Hippe H.J., Lutz S., Cuello F., Knorr K., Vogt A., Jakobs K.H., Wieland T., Niroomand F.
    J Biol Chem 278:7227-7233(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• GTPase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• GTP binding Source: RGDInferred from direct assayⁱ
  • "Functional characterization of heterotrimeric G-proteins in rat diaphragm muscle."
    Andrade-Lopes A.L., Pires-Oliveira M., Menezes-Rodrigues F.S., Godinho R.O.
    Respir Physiol Neurobiol 175:212-219(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor receptor binding Source: RGDInferred from physical interactionⁱ
  • "Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II."
    Chu C.H., Huang C.Y., Lu M.C., Lin J.A., Tsai F.J., Tsai C.H., Chu C.Y., Kuo W.H., Chen L.M., Chen L.Y.
    Chin J Physiol 52:31-37(2009) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• mu-type opioid receptor binding Source: RGDInferred from direct assayⁱ
  • "Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein."
    Wang H.Y., Burns L.H.
    J Neurobiol 66:1302-1310(2006) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "Two overlapping reading frames in a single exon encode interacting proteins -- a novel way of gene usage."
    Klemke M., Kehlenbach R.H., Huttner W.B.
    EMBO J. 20:3849-3860(2001) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-activating adrenergic receptor signaling pathway Source: RGD
• adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney."
    Kim S.W., Kim J.W., Choi K.C., Ma S.K., Oh Y., Jung J.Y., Kim J., Lee J.
    J Am Soc Nephrol 15:2998-3005(2004) [PubMed] [Europe PMC] [Abstract]
  • "Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein."
    Wang H.Y., Burns L.H.
    J Neurobiol 66:1302-1310(2006) [PubMed] [Europe PMC] [Abstract]
  • "Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver."
    Merlen C., Fabrega S., Desbuquois B., Unson C.G., Authier F.
    FEBS Lett 580:5697-5704(2006) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• bone development Source: RGD
• calcium ion homeostasis Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transgenic overexpression of the extra-large Gsalpha variant XLalphas enhances Gsalpha-mediated responses in the mouse renal proximal tubule in vivo."
    Liu Z., Segawa H., Aydin C., Reyes M., Erben R.G., Weinstein L.S., Chen M., Marshansky V., Frohlich L.F., Bastepe M.
    Endocrinology 152:1222-1233(2011) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: RGD
• cognition Source: RGD
• developmental growth Source: RGD
• DNA methylation Source: RGD
• embryonic cranial skeleton morphogenesis Source: RGD
• embryonic hindlimb morphogenesis Source: RGD
• endochondral ossification Source: RGD
• energy reserve metabolic process Source: RGD
• genetic imprinting Source: RGD
• G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise."
    Charbonneau A., Melancon A., Lavoie C., Lavoie J.M.
    Am J Physiol Endocrinol Metab 289:E8-14(2005) [PubMed] [Europe PMC] [Abstract]
• hair follicle placode formation Source: RGD
• multicellular organism growth Source: RGD
• negative regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "Functional selectivity of central Galpha-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central alpha(2) -adrenoceptor activation in vivo."
    Wainford R.D., Kapusta D.R.
    Br J Pharmacol 166:210-220(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of multicellular organism growth Source: RGD
• negative regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • "Functional selectivity of central Galpha-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central alpha(2) -adrenoceptor activation in vivo."
    Wainford R.D., Kapusta D.R.
    Br J Pharmacol 166:210-220(2012) [PubMed] [Europe PMC] [Abstract]
• platelet aggregation Source: RGD
• positive regulation of cAMP-mediated signaling Source: RGD
• positive regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Conditional overexpression of the wild-type Gs alpha as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines."
    Romano D., Magalon K., Pertuit M., Rasolonjanahary R., Barlier A., Enjalbert A., Gerard C.
    Endocrinology 148:2973-2983(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis."
    Chen M., Chen H., Nguyen A., Gupta D., Wang J., Lai E.W., Pacak K., Gavrilova O., Quon M.J., Weinstein L.S.
    Cell Metab 11:320-330(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: RGD
• positive regulation of osteoblast differentiation Source: RGD
• positive regulation of osteoclast differentiation Source: RGD
• positive regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "Transgenic overexpression of the extra-large Gsalpha variant XLalphas enhances Gsalpha-mediated responses in the mouse renal proximal tubule in vivo."
    Liu Z., Segawa H., Aydin C., Reyes M., Erben R.G., Weinstein L.S., Chen M., Marshansky V., Frohlich L.F., Bastepe M.
    Endocrinology 152:1222-1233(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of sodium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "Modulation of rat cardiac sodium channel by the stimulatory G protein alpha subunit."
    Lu T., Lee H.C., Kabat J.A., Shibata E.F.
    J Physiol 518:371-384(1999) [PubMed] [Europe PMC] [Abstract]
• post-embryonic body morphogenesis Source: RGD
• post-embryonic development Source: RGD
• regulation of parathyroid hormone secretion Source: RGD
• regulation of signal transduction Source: RGD
• regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells."
    Wang J., Gilchrist A., Stern P.H.
    Cell Signal 23:380-388(2011) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGD
• response to parathyroid hormone Source: RGD
• sensory perception of chemical stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: RGD
• skin development Source: RGD
• tissue homeostasis Source: RGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• alpha-tubulin binding Source: RGDInferred from direct assayⁱ
  • "G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells."
    Montoya V., Gutierrez C., Najera O., Leony D., Varela-Ramirez A., Popova J., Rasenick M.M., Das S., Roychowdhury S.
    Cell Motil Cytoskeleton 64:936-950(2007) [PubMed] [Europe PMC] [Abstract]
• beta-2 adrenergic receptor binding Source: RGDInferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• corticotropin-releasing hormone receptor 1 binding Source: RGDInferred from physical interactionⁱ
  • "Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology."
    Bangasser D.A., Curtis A., Reyes B.A., Bethea T.T., Parastatidis I., Ischiropoulos H., Van Bockstaele E.J., Valentino R.J.
    Mol Psychiatry 15:877, 2010:896-904(2010) [PubMed] [Europe PMC] [Abstract]
• D1 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am J Physiol Renal Physiol 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Two overlapping reading frames in a single exon encode interacting proteins -- a novel way of gene usage."
    Klemke M., Kehlenbach R.H., Huttner W.B.
    EMBO J. 20:3849-3860(2001) [PubMed] [Europe PMC] [Abstract]
• G-protein beta-subunit binding Source: RGDInferred from direct assayⁱ
  • "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells."
    Hippe H.J., Lutz S., Cuello F., Knorr K., Vogt A., Jakobs K.H., Wieland T., Niroomand F.
    J Biol Chem 278:7227-7233(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor receptor binding Source: RGDInferred from physical interactionⁱ
  • "Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II."
    Chu C.H., Huang C.Y., Lu M.C., Lin J.A., Tsai F.J., Tsai C.H., Chu C.Y., Kuo W.H., Chen L.M., Chen L.Y.
    Chin J Physiol 52:31-37(2009) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor binding Source: RGDInferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• mu-type opioid receptor binding Source: RGDInferred from direct assayⁱ
  • "Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein."
    Wang H.Y., Burns L.H.
    J Neurobiol 66:1302-1310(2006) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "Two overlapping reading frames in a single exon encode interacting proteins -- a novel way of gene usage."
    Klemke M., Kehlenbach R.H., Huttner W.B.
    EMBO J. 20:3849-3860(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDRRSRAHQW RRARHNYNDL CPPIGRRAAT ALLWLSCSIA LLRALASSNA 
        60         70         80         90        100
RAQQRAAQRR SFLNAHHRSA AAAAAAQVLP ESSESESDHE HEEAEPELAR 
       110        120        130        140        150
PECLEYDQDD YETETDSETE PESDIQSETE FETEPETEPE TAPTTEPETE 
       160        170        180        190        200
PEDERGPRGA TFNQSLTQRL HALKLQSADA SPRRAQPTTQ EPESASEGEE 
       210        220        230        240        250
PQREPLDEDP RDPEESEERR EANRQPRRCK TRRPARRRDQ SPESPPRKGP 

IPIRRH                                                 

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families