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Protein
Submitted name:

Alpha-4 integrin

Gene

Itga4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-4 integrinImported
Submitted name:
Integrin alpha-4Imported
Submitted name:
Integrin alpha-4 subunitImported
Gene namesi
Name:Itga4Imported
ORF Names:mCG_20065Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96603 Itga4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei976 – 1000HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33UniRule annotationAdd BLAST33
ChainiPRO_501502009634 – 1032UniRule annotationAdd BLAST999

Expressioni

Gene expression databases

BgeeiENSMUSG00000027009 Expressed in 268 organ(s), highest expression level in blood

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 100FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati110 – 177FG-GAPPROSITE-ProRule annotationAdd BLAST68
Repeati186 – 237FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati239 – 291FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati292 – 351FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati355 – 412FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati416 – 478FG-GAPPROSITE-ProRule annotationAdd BLAST63
Domaini463 – 856Integrin_alpha2InterPro annotationAdd BLAST394

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPB2 Eukaryota
ENOG410XTAR LUCA
GeneTreeiENSGT00760000118782
HOVERGENiHBG004538
KOiK06483
OMAiNRRDSWS
OrthoDBiEOG091G011V
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 6 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q792F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEARCRPR SRGIALREAV MLLLYFGVPT GHSYNLDPEN ALLYQGPSGT
60 70 80 90 100
LFGYSVVLHS HGSKRWLIVG APTASWLSNA SVVNPGAIYR CGIRKNPNQT
110 120 130 140 150
CEQLQLGSPS GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN
160 170 180 190 200
IFYMKSDNKL PTGICYVMPS DLRTELSKRM APCYKDYTRK FGENFASCQA
210 220 230 240 250
GISSFYTQDL IVMGAPGSSY WTGTVFVYNI TTNQYKAFVD RQNQVKFGSY
260 270 280 290 300
LGYSVGAGHF RSPHTTEVVG GAPQHEQIGK AYIFSIDENE LNIVYEMKGK
310 320 330 340 350
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGMGAV
360 370 380 390 400
MVEMERVLVG SDKYAARFGE SIANLGDIDN DGFEDIAIGA PQEDDLRGAV
410 420 430 440 450
YIYNGRVDGI SSTYSQRIEG QQISKSLRMF GQSISGQIDA DNNGYVDVAV
460 470 480 490 500
GAFQSDSAVL LRTRPVVIVE ASLSHPESVN RTKFDCTENG LPSVCMHLTL
510 520 530 540 550
CFSYKGKEVP GYIVLFYNVS LDVHRKAESP SRFYFFSNGT SDVITGSIRV
560 570 580 590 600
SSSGEKCRTH QAFMRKDVRD ILTPIHVEAT YHLGHHVITK RNTEEFPPLQ
610 620 630 640 650
PILQQKKEKD VIRKMINFAR FCAYENCSAD LQVSAKVGFL KPYENKTYLA
660 670 680 690 700
VGSMKTIMLN VSLFNAGDDA YETTLNVQLP TGLYFIKILD LEEKQINCEV
710 720 730 740 750
TESSGIVKLA CSLGYIYVDR LSRIDISFLL DVSSLSRAHE DLSISVHASC
760 770 780 790 800
ENEGELDQVR DNRVTLTIPL RYEVMLTVHG LVNPTSFVYG SSEENEPETC
810 820 830 840 850
MAEKLNLTFH VINTGISMAP NVSVKIMVPN SFLPQDDKLF NVLDVQTTTG
860 870 880 890 900
QCHFKHYGRE CTFAQQKGIA GTLTDIVKFL SKTDKRLLYC MKADQHCLDF
910 920 930 940 950
LCNFGKMESG KEASVHIQLE GRPSILEMDE TSSLKFEIKA TAFPEPHPKV
960 970 980 990 1000
IELNKDENVA HVFLEGLHHQ RPKRHFTIII ITISLLLGLI VLLLISCVMW
1010 1020 1030
KAGFFKRQYK SILQEENRRD SWSYVNSKSN DD
Length:1,032
Mass (Da):115,086
Last modified:July 5, 2004 - v1
Checksum:i6E99ED8B589EF060
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q00651ITA4_MOUSE
Integrin alpha-4
Itga4
1,039Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844590 Genomic DNA No translation available.
AH003666
, U34627, U34628, U34629, U34631, U34632, U34633, U34634, U34635, U34763, U34764, U34765, U34766, U34767, U34768, U34769, U34770, U34797, U34798, U34799 Genomic DNA Translation: AAB09630.1
AF109136 mRNA Translation: AAC95388.1
CH466519 Genomic DNA Translation: EDL27240.1
RefSeqiNP_034706.3, NM_010576.3
UniGeneiMm.31903

Genome annotation databases

EnsembliENSMUST00000099972; ENSMUSP00000099718; ENSMUSG00000027009
GeneIDi16401
KEGGimmu:16401
UCSCiuc008kgr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ792F9_MOUSE
AccessioniPrimary (citable) accession number: Q792F9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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