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Protein

Mitochondrial carrier homolog 2

Gene

Mtch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity).By similarity

GO - Biological processi

  • cellular response to radiation Source: MGI
  • establishment of protein localization to mitochondrial membrane involved in mitochondrial fission Source: MGI
  • hematopoietic stem cell homeostasis Source: MGI
  • hematopoietic stem cell migration Source: MGI
  • hepatocyte apoptotic process Source: MGI
  • lactate metabolic process Source: MGI
  • mitochondrial ATP synthesis coupled electron transport Source: MGI
  • negative regulation of glycolytic process Source: MGI
  • negative regulation of mitochondrial membrane potential Source: MGI
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • protein localization to mitochondrion Source: MGI
  • regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 2
Gene namesi
Name:Mtch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1929260 Mtch2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906382 – 303Mitochondrial carrier homolog 2Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ791V5
MaxQBiQ791V5
PaxDbiQ791V5
PRIDEiQ791V5

PTM databases

iPTMnetiQ791V5
PhosphoSitePlusiQ791V5
SwissPalmiQ791V5

Expressioni

Gene expression databases

BgeeiENSMUSG00000027282
CleanExiMM_MTCH2
ExpressionAtlasiQ791V5 baseline and differential
GenevisibleiQ791V5 MM

Interactioni

Protein-protein interaction databases

BioGridi207972, 3 interactors
IntActiQ791V5, 5 interactors
MINTiQ791V5
STRINGi10090.ENSMUSP00000121851

Structurei

3D structure databases

ProteinModelPortaliQ791V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 98Solcar 1Add BLAST97
Repeati118 – 206Solcar 2Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2745 Eukaryota
ENOG410XSXF LUCA
GeneTreeiENSGT00390000000020
HOGENOMiHOG000231394
HOVERGENiHBG058632
InParanoidiQ791V5
KOiK17885
PhylomeDBiQ791V5
TreeFamiTF313721

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q791V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ
60 70 80 90 100
LPGLFCYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQYYQESEK
110 120 130 140 150
PEELGSVTVQ KEYSSSFDRV IKETTREMIA RSAATLITHP FHVITLRSMV
160 170 180 190 200
QFIGRESKYC GLCDSIVTIY REEGIVGFFA GLIPRLLGDI ISLWLCNSLA
210 220 230 240 250
YLINTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG
260 270 280 290 300
LAGGSPPYSP IYTSWIDCWC MLQKAGNMSR GNSLFFRKVP CGKTYCYDLR

MLI
Length:303
Mass (Da):33,499
Last modified:July 5, 2004 - v1
Checksum:i248F8A1E4CF29975
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206Y → C in BAB27839 (PubMed:16141072).Curated1
Sequence conflicti207A → T in BAB25848 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176009 mRNA Translation: AAD52647.1
AK003100 mRNA Translation: BAB22565.1
AK008487 mRNA Translation: BAB25694.1
AK008712 mRNA Translation: BAB25848.1
AK011785 mRNA Translation: BAB27839.1
AK011874 mRNA Translation: BAB27892.1
AK075890 mRNA Translation: BAC36033.1
AK161441 mRNA Translation: BAE36399.1
AK164169 mRNA Translation: BAE37660.1
BC002152 mRNA Translation: AAH02152.1
BC038899 mRNA Translation: AAH38899.1
BC038916 mRNA Translation: AAH38916.1
CCDSiCCDS16416.1
RefSeqiNP_001304170.1, NM_001317241.1
NP_001304171.1, NM_001317242.1
NP_001304172.1, NM_001317243.1
NP_001304173.1, NM_001317244.1
NP_062732.1, NM_019758.3
UniGeneiMm.28023

Genome annotation databases

EnsembliENSMUST00000136872; ENSMUSP00000121851; ENSMUSG00000027282
ENSMUST00000214148; ENSMUSP00000149233; ENSMUSG00000111714
GeneIDi56428
KEGGimmu:56428
UCSCiuc008ktn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTCH2_MOUSE
AccessioniPrimary (citable) accession number: Q791V5
Secondary accession number(s): Q3TPS5
, Q99LZ6, Q9D060, Q9D7Y2, Q9QZP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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