UniProtKB - Q791T5 (MTCH1_MOUSE)
Protein
Mitochondrial carrier homolog 1
Gene
Mtch1
Organism
Mus musculus (Mouse)
Status
Functioni
Potential mitochondrial transporter. May play a role in apoptosis (By similarity).By similarity
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- apoptotic process Source: UniProtKB-KW
- positive regulation of apoptotic process Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial carrier homolog 1Alternative name(s): Mitochondrial carrier-like protein 1 |
Gene namesi | Name:Mtch1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929261, Mtch1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 315 – 335 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232386 | 1 – 389 | Mitochondrial carrier homolog 1Add BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
jPOSTi | Q791T5 |
PaxDbi | Q791T5 |
PeptideAtlasi | Q791T5 |
PRIDEi | Q791T5 |
PTM databases
iPTMneti | Q791T5 |
PhosphoSitePlusi | Q791T5 |
SwissPalmi | Q791T5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024012, Expressed in ear vesicle and 301 other tissues |
ExpressionAtlasi | Q791T5, baseline and differential |
Genevisiblei | Q791T5, MM |
Interactioni
Subunit structurei
Interacts with PSEN1.
By similarityProtein-protein interaction databases
IntActi | Q791T5, 1 interactor |
STRINGi | 10090.ENSMUSP00000093077 |
Miscellaneous databases
RNActi | Q791T5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 81 – 176 | Solcar 1Add BLAST | 96 | |
Repeati | 192 – 280 | Solcar 2Add BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2745, Eukaryota |
GeneTreei | ENSGT00390000000020 |
HOGENOMi | CLU_058300_1_0_1 |
InParanoidi | Q791T5 |
OMAi | PNIFQYA |
OrthoDBi | 1439019at2759 |
PhylomeDBi | Q791T5 |
TreeFami | TF313721 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 1 hit |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q791T5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH
60 70 80 90 100
PRHPRPAAQP SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL
110 120 130 140 150
YVKLLIQVGH EPMPPTLGTN VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR
160 170 180 190 200
GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ VSNKDDMKTS LKKVVKETSY
210 220 230 240 250
EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI GKIFKEEGLL
260 270 280 290 300
GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG
310 320 330 340 350
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS
360 370 380
PVFKSWIHCW KYLSVQGQLF RGSSLLFRRV SSGSCFALE
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YXC2 | D3YXC2_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 294 | Annotation score: | ||
A0A3Q4EG99 | A0A3Q4EG99_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 260 | Annotation score: | ||
A0A3Q4EGL4 | A0A3Q4EGL4_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 311 | Annotation score: | ||
A0A3Q4EIA3 | A0A3Q4EIA3_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 199 | Annotation score: | ||
A0A3Q4EBT8 | A0A3Q4EBT8_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 277 | Annotation score: | ||
A0A3Q4EC24 | A0A3Q4EC24_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 299 | Annotation score: | ||
A0A3Q4EC97 | A0A3Q4EC97_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 112 | Annotation score: | ||
A0A3Q4EGX8 | A0A3Q4EGX8_MOUSE | Mitochondrial carrier homolog 1 | Mtch1 | 63 | Annotation score: |
Sequence cautioni
The sequence AAH23135 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH26436 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH27274 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32313 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | P → A in BAE32313 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 46 | A → G in BAE32313 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017883 | 286 – 302 | Missing in isoform 2. 3 PublicationsAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040292 Genomic DNA Translation: BAA92860.1 AB040292 Genomic DNA Translation: BAA92861.1 AF176007 mRNA Translation: AAD52645.2 AF192558 mRNA Translation: AAF12792.2 AY301264 Genomic DNA Translation: AAP45196.1 AY301264 Genomic DNA Translation: AAP45202.1 AK154010 mRNA Translation: BAE32313.1 Different initiation. BC023135 mRNA Translation: AAH23135.1 Different initiation. BC026436 mRNA Translation: AAH26436.1 Different initiation. BC027274 mRNA Translation: AAH27274.1 Different initiation. |
CCDSi | CCDS28596.1 [Q791T5-1] CCDS84288.1 [Q791T5-2] |
RefSeqi | NP_001334264.1, NM_001347335.1 [Q791T5-2] NP_063933.1, NM_019880.3 [Q791T5-1] XP_006524731.1, XM_006524668.1 [Q791T5-1] XP_006524733.1, XM_006524670.1 [Q791T5-2] |
Genome annotation databases
Ensembli | ENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012 [Q791T5-1] ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012 [Q791T5-2] |
GeneIDi | 56462 |
KEGGi | mmu:56462 |
UCSCi | uc008bst.1, mouse [Q791T5-1] uc008bsu.1, mouse [Q791T5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040292 Genomic DNA Translation: BAA92860.1 AB040292 Genomic DNA Translation: BAA92861.1 AF176007 mRNA Translation: AAD52645.2 AF192558 mRNA Translation: AAF12792.2 AY301264 Genomic DNA Translation: AAP45196.1 AY301264 Genomic DNA Translation: AAP45202.1 AK154010 mRNA Translation: BAE32313.1 Different initiation. BC023135 mRNA Translation: AAH23135.1 Different initiation. BC026436 mRNA Translation: AAH26436.1 Different initiation. BC027274 mRNA Translation: AAH27274.1 Different initiation. |
CCDSi | CCDS28596.1 [Q791T5-1] CCDS84288.1 [Q791T5-2] |
RefSeqi | NP_001334264.1, NM_001347335.1 [Q791T5-2] NP_063933.1, NM_019880.3 [Q791T5-1] XP_006524731.1, XM_006524668.1 [Q791T5-1] XP_006524733.1, XM_006524670.1 [Q791T5-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q791T5, 1 interactor |
STRINGi | 10090.ENSMUSP00000093077 |
PTM databases
iPTMneti | Q791T5 |
PhosphoSitePlusi | Q791T5 |
SwissPalmi | Q791T5 |
Proteomic databases
jPOSTi | Q791T5 |
PaxDbi | Q791T5 |
PeptideAtlasi | Q791T5 |
PRIDEi | Q791T5 |
Protocols and materials databases
Antibodypediai | 3010, 144 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012 [Q791T5-1] ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012 [Q791T5-2] |
GeneIDi | 56462 |
KEGGi | mmu:56462 |
UCSCi | uc008bst.1, mouse [Q791T5-1] uc008bsu.1, mouse [Q791T5-2] |
Organism-specific databases
CTDi | 23787 |
MGIi | MGI:1929261, Mtch1 |
Phylogenomic databases
eggNOGi | KOG2745, Eukaryota |
GeneTreei | ENSGT00390000000020 |
HOGENOMi | CLU_058300_1_0_1 |
InParanoidi | Q791T5 |
OMAi | PNIFQYA |
OrthoDBi | 1439019at2759 |
PhylomeDBi | Q791T5 |
TreeFami | TF313721 |
Miscellaneous databases
BioGRID-ORCSi | 56462, 3 hits in 19 CRISPR screens |
ChiTaRSi | Mtch1, mouse |
PROi | PR:Q791T5 |
RNActi | Q791T5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024012, Expressed in ear vesicle and 301 other tissues |
ExpressionAtlasi | Q791T5, baseline and differential |
Genevisiblei | Q791T5, MM |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 1 hit |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTCH1_MOUSE | |
Accessioni | Q791T5Primary (citable) accession number: Q791T5 Secondary accession number(s): Q3U4W7 Q9QZP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families