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Protein

Nucleosome assembly protein 1-like 4

Gene

Nap1l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as histone chaperone in nucleosome assembly (PubMed:28366643). In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AFB1 and HIST1H2BA/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells (PubMed:28366643).1 Publication

GO - Molecular functioni

GO - Biological processi

  • nucleosome assembly Source: UniProtKB

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 4
Gene namesi
Name:Nap1l4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1316687 Nap1l4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002362132 – 375Nucleosome assembly protein 1-like 4Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei58PhosphothreonineBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei125PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei304PhosphoserineCombined sources1

Post-translational modificationi

Polyglutamylated and polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Polyglutamylated by TTLL4.1 Publication
Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ78ZA7
MaxQBiQ78ZA7
PaxDbiQ78ZA7
PRIDEiQ78ZA7

PTM databases

iPTMnetiQ78ZA7
PhosphoSitePlusiQ78ZA7

Expressioni

Gene expression databases

BgeeiENSMUSG00000059119 Expressed in 268 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_NAP1L4
ExpressionAtlasiQ78ZA7 baseline and differential
GenevisibleiQ78ZA7 MM

Interactioni

Subunit structurei

Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.By similarity

Protein-protein interaction databases

BioGridi201692, 3 interactors
IntActiQ78ZA7, 4 interactors
MINTiQ78ZA7
STRINGi10090.ENSMUSP00000072510

Structurei

3D structure databases

ProteinModelPortaliQ78ZA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 271Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 131Poly-Glu6
Compositional biasi301 – 310Asp/Glu-rich (acidic)10
Compositional biasi347 – 370Asp/Glu-rich (acidic)Add BLAST24

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ78ZA7
KOiK11282
OMAiSQPSECK
OrthoDBiEOG091G0HVV
PhylomeDBiQ78ZA7
TreeFamiTF314349

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q78ZA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENSLSDGG PADSVEAAKN ASNTEKLTDQ VMQNPQVLAA LQERLDNVSH
60 70 80 90 100
TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ
110 120 130 140 150
PLFDKRREFI TGDVEPTDAE SAWHSENEEE DKLAGDMKNK VVIAEKEAAT
160 170 180 190 200
VEELNPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ
210 220 230 240 250
PMSFVLEFHF EPNDYFTNPV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC
260 270 280 290 300
TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFSPLKASG
310 320 330 340 350
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE
360 370
EGEEEELEGD EEGEDEDDAD VNPKV
Length:375
Mass (Da):42,679
Last modified:July 5, 2004 - v1
Checksum:iA249E440F09072A6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZNL2B7ZNL2_MOUSE
Nap1l4 protein
Nap1l4 mCG_129001
386Annotation score:
A0A140LI78A0A140LI78_MOUSE
Nucleosome assembly protein 1-like ...
Nap1l4
58Annotation score:
A0A140LJB5A0A140LJB5_MOUSE
Nucleosome assembly protein 1-like ...
Nap1l4
219Annotation score:
A0A140LJ37A0A140LJ37_MOUSE
Nucleosome assembly protein 1-like ...
Nap1l4
75Annotation score:
A0A140LI20A0A140LI20_MOUSE
Nucleosome assembly protein 1-like ...
Nap1l4
43Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002198 mRNA Translation: CAA05245.1
AJ276505 Genomic DNA Translation: CAC16399.1
CCDSiCCDS40197.1
RefSeqiNP_001272418.1, NM_001285489.1
NP_001272419.1, NM_001285490.1
NP_032698.1, NM_008672.3
UniGeneiMm.294625

Genome annotation databases

EnsembliENSMUST00000072727; ENSMUSP00000072510; ENSMUSG00000059119
GeneIDi17955
KEGGimmu:17955
UCSCiuc009kpl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002198 mRNA Translation: CAA05245.1
AJ276505 Genomic DNA Translation: CAC16399.1
CCDSiCCDS40197.1
RefSeqiNP_001272418.1, NM_001285489.1
NP_001272419.1, NM_001285490.1
NP_032698.1, NM_008672.3
UniGeneiMm.294625

3D structure databases

ProteinModelPortaliQ78ZA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201692, 3 interactors
IntActiQ78ZA7, 4 interactors
MINTiQ78ZA7
STRINGi10090.ENSMUSP00000072510

PTM databases

iPTMnetiQ78ZA7
PhosphoSitePlusiQ78ZA7

Proteomic databases

EPDiQ78ZA7
MaxQBiQ78ZA7
PaxDbiQ78ZA7
PRIDEiQ78ZA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072727; ENSMUSP00000072510; ENSMUSG00000059119
GeneIDi17955
KEGGimmu:17955
UCSCiuc009kpl.2 mouse

Organism-specific databases

CTDi4676
MGIiMGI:1316687 Nap1l4

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ78ZA7
KOiK11282
OMAiSQPSECK
OrthoDBiEOG091G0HVV
PhylomeDBiQ78ZA7
TreeFamiTF314349

Miscellaneous databases

PROiPR:Q78ZA7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059119 Expressed in 268 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_NAP1L4
ExpressionAtlasiQ78ZA7 baseline and differential
GenevisibleiQ78ZA7 MM

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNP1L4_MOUSE
AccessioniPrimary (citable) accession number: Q78ZA7
Secondary accession number(s): O88701
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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