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Protein

Phosducin-like protein 2

Gene

Pdcl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in germ cell maturation.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 2
Alternative name(s):
MgcPhLP
Phosducin-like protein similar 1
Gene namesi
Name:Pdcl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1890655 Pdcl2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461581 – 240Phosducin-like protein 2Add BLAST240

Proteomic databases

PaxDbiQ78Y63
PRIDEiQ78Y63

PTM databases

PhosphoSitePlusiQ78Y63

Expressioni

Tissue specificityi

Predominantly, if not exclusively, expressed in male and female germ cells. In the male germ cells, expressed from the meiotic to the late haploid stages of spermatogenesis and in the mature spermatozoa of epididymal sperm (at protein level). Also detected in fertilized eggs (at protein level).1 Publication

Inductioni

Up-regulated at the protein level as early as 3 hours after chorionic gonadotropin treatment in the ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000029235 Expressed in 33 organ(s), highest expression level in testis
CleanExiMM_PDCL2
GenevisibleiQ78Y63 MM

Interactioni

Subunit structurei

Forms a complex with 14-3-3 protein(s).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031145

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ78Y63
SMRiQ78Y63
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ78Y63

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 240Thioredoxin foldBy similarityAdd BLAST152

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170 Eukaryota
ENOG4111H24 LUCA
GeneTreeiENSGT00910000144176
HOGENOMiHOG000184445
HOVERGENiHBG108238
InParanoidiQ78Y63
OMAiEEDMQAI
OrthoDBiEOG091G0QP8
PhylomeDBiQ78Y63
TreeFamiTF315179

Family and domain databases

InterProiView protein in InterPro
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q78Y63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQDPNEDTEW NEILRNFGIL PPKEEPKDEI EEMVLRLQQE AMVKPYEKMT
60 70 80 90 100
LAQLKEAEDE FDEEDIKAIE IYREKRLQEW KALKKKQKFG ELREISGNQY
110 120 130 140 150
VNEVTNAEKD LWVVIHLYRS SVPMCLVVNQ HLSVLARKFP ETKFVKAIVN
160 170 180 190 200
SCIEHYHDNC LPTIFVYKNG QIEGKFIGII ECGGINLKLE ELEWKLSEVG
210 220 230 240
AIQSDLEENP KKGIADMMVS SIRNISIYDS DSSGSDTEAK
Length:240
Mass (Da):27,770
Last modified:July 5, 2004 - v1
Checksum:i580715EFE61E86F1
GO
Isoform 2 (identifier: Q78Y63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:192
Mass (Da):21,986
Checksum:i81821B6DA7C859B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209N → T in AAD30564 (PubMed:11116088).Curated1
Sequence conflicti210 – 212PKK → TKR in BAB24379 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0223601 – 48Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005602 mRNA Translation: BAB24145.1
AK005814 mRNA Translation: BAB24251.1
AK006040 mRNA Translation: BAB24379.1
AK132738 mRNA Translation: BAE21326.1
AK133140 mRNA Translation: BAE21527.1
BC048432 mRNA Translation: AAH48432.1
AF146793 Genomic DNA Translation: AAD30564.2
CCDSiCCDS39116.1 [Q78Y63-1]
CCDS80304.1 [Q78Y63-2]
RefSeqiNP_001297566.1, NM_001310637.1 [Q78Y63-2]
NP_075997.1, NM_023508.7 [Q78Y63-1]
UniGeneiMm.143764

Genome annotation databases

EnsembliENSMUST00000031145; ENSMUSP00000031145; ENSMUSG00000029235 [Q78Y63-1]
ENSMUST00000122213; ENSMUSP00000113699; ENSMUSG00000029235 [Q78Y63-2]
GeneIDi79455
KEGGimmu:79455
UCSCiuc008xuu.1 mouse [Q78Y63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDCL2_MOUSE
AccessioniPrimary (citable) accession number: Q78Y63
Secondary accession number(s): Q3V0H7, Q9DA99, Q9WUP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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