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Protein

Actin-associated protein FAM107A

Gene

Fam107a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics (PubMed:21969592). Mediates polymerization of globular actin to F-actin (PubMed:21969592). Also binds to, stabilizes and bundles F-actin (PubMed:21969592). Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Growth regulation, Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-associated protein FAM107ACurated
Gene namesi
Name:Fam107aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3041256 Fam107a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004449551 – 144Actin-associated protein FAM107AAdd BLAST144

Proteomic databases

PaxDbiQ78TU8
PRIDEiQ78TU8

Expressioni

Tissue specificityi

Expressed in septum, the neocortex, the CA3 region of the hippocampus and the cerebellum (at protein level).1 Publication

Inductioni

Up-regulated in the hypothalamic paraventricular nucleus (PVN) and the CA3 region of the hippocampus of the brain in response to postnatal maternal separation or food deprivation and glucocorticoids stimulation in adult animals (PubMed:21969592). Up-regulated in CA1, CA3 and dente gyrus regions of the hippocampus in response to acute social defeat stress or glucocorticoids stimulation (PubMed:25637808).2 Publications

Gene expression databases

BgeeiENSMUSG00000021750 Expressed in 199 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ78TU8 baseline and differential

Interactioni

Subunit structurei

Interacts with ACTB (PubMed:21969592). Interacts with F-actin (PubMed:21969592). Interacts with PRDX1 (PubMed:21969592). Interacts with COMMD1; this interaction stabilizes COMMD1 in the nucleus (By similarity). Interacts with MAP1A (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045513

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 90Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 84Nuclear localization signalBy similarityAdd BLAST11

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IX5W Eukaryota
ENOG4111Z4D LUCA
GeneTreeiENSGT00390000011228
HOGENOMiHOG000048230
HOVERGENiHBG002824
InParanoidiQ78TU8
OMAiMNHRRGI
OrthoDBiEOG091G0FHS
PhylomeDBiQ78TU8
TreeFamiTF325943

Family and domain databases

InterProiView protein in InterPro
IPR009533 FAM107
PANTHERiPTHR16768 PTHR16768, 1 hit
PfamiView protein in Pfam
PF06625 DUF1151, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q78TU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSEIQRERA DIEGLMARPE YREWNSELIK PKKLLNPVKA SRSHQELHRE
60 70 80 90 100
LLMNHKRGLG MDSKPELQRV LEHRRRNQLI KKKEEELEAK RMQCPFKQEL
110 120 130 140
LRRQQRLNQL ENPPQRDEDH APEFIKVREN LRRITTLTSE ERAL
Length:144
Mass (Da):17,510
Last modified:October 11, 2005 - v1
Checksum:iBFD0BB9754817054
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9C450A9C450_MOUSE
Actin-associated protein FAM107A
Fam107a
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044219 mRNA Translation: BAC31824.1
CT025547 Genomic DNA No translation available.
BC055107 mRNA Translation: AAH55107.1
CCDSiCCDS26813.1
RefSeqiNP_899010.1, NM_183187.3
XP_006518083.1, XM_006518020.2
XP_006518084.1, XM_006518021.2
XP_006518085.1, XM_006518022.2
XP_006518086.1, XM_006518023.2
UniGeneiMm.256058
Mm.472988

Genome annotation databases

EnsembliENSMUST00000036070; ENSMUSP00000045513; ENSMUSG00000021750
ENSMUST00000120411; ENSMUSP00000112769; ENSMUSG00000021750
ENSMUST00000121887; ENSMUSP00000114015; ENSMUSG00000021750
GeneIDi268709
UCSCiuc007sfa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044219 mRNA Translation: BAC31824.1
CT025547 Genomic DNA No translation available.
BC055107 mRNA Translation: AAH55107.1
CCDSiCCDS26813.1
RefSeqiNP_899010.1, NM_183187.3
XP_006518083.1, XM_006518020.2
XP_006518084.1, XM_006518021.2
XP_006518085.1, XM_006518022.2
XP_006518086.1, XM_006518023.2
UniGeneiMm.256058
Mm.472988

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045513

Proteomic databases

PaxDbiQ78TU8
PRIDEiQ78TU8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036070; ENSMUSP00000045513; ENSMUSG00000021750
ENSMUST00000120411; ENSMUSP00000112769; ENSMUSG00000021750
ENSMUST00000121887; ENSMUSP00000114015; ENSMUSG00000021750
GeneIDi268709
UCSCiuc007sfa.1 mouse

Organism-specific databases

CTDi11170
MGIiMGI:3041256 Fam107a

Phylogenomic databases

eggNOGiENOG410IX5W Eukaryota
ENOG4111Z4D LUCA
GeneTreeiENSGT00390000011228
HOGENOMiHOG000048230
HOVERGENiHBG002824
InParanoidiQ78TU8
OMAiMNHRRGI
OrthoDBiEOG091G0FHS
PhylomeDBiQ78TU8
TreeFamiTF325943

Miscellaneous databases

ChiTaRSiFam107a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021750 Expressed in 199 organ(s), highest expression level in utricle of membranous labyrinth
ExpressionAtlasiQ78TU8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009533 FAM107
PANTHERiPTHR16768 PTHR16768, 1 hit
PfamiView protein in Pfam
PF06625 DUF1151, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF107A_MOUSE
AccessioniPrimary (citable) accession number: Q78TU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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