Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar ATPase assembly integral membrane protein Vma21

Gene

Vma21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar ATPase assembly integral membrane protein Vma21UniRule annotation
Gene namesi
Name:Vma21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914298 Vma21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicUniRule annotationAdd BLAST25
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Topological domaini47 – 65LumenalUniRule annotationAdd BLAST19
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Topological domaini87 – 101CytoplasmicUniRule annotationAdd BLAST15

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315001 – 101Vacuolar ATPase assembly integral membrane protein Vma21Add BLAST101

Proteomic databases

PaxDbiQ78T54
PeptideAtlasiQ78T54
PRIDEiQ78T54
TopDownProteomicsiQ78T54-1 [Q78T54-1]
Q78T54-2 [Q78T54-2]

PTM databases

iPTMnetiQ78T54
PhosphoSitePlusiQ78T54

Expressioni

Gene expression databases

BgeeiENSMUSG00000073131 Expressed in 270 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ78T54 baseline and differential
GenevisibleiQ78T54 MM

Interactioni

Subunit structurei

Associates with the V0 complex of the vacuolar ATPase (V-ATPase).UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110223

Structurei

3D structure databases

SMRiQ78T54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMA21 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4783 Eukaryota
ENOG411241C LUCA
GeneTreeiENSGT00390000017980
HOGENOMiHOG000154822
InParanoidiQ78T54
TreeFamiTF314021

Family and domain databases

HAMAPiMF_03058 VMA21, 1 hit
InterProiView protein in InterPro
IPR019013 Vma21
PANTHERiPTHR31792 PTHR31792, 1 hit
PfamiView protein in Pfam
PF09446 VMA21, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q78T54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLDKAALN ALQPPEFRNE NSLAATLKTL LFFTALMITV PIGLYFTTKA
60 70 80 90 100
YIFEGALGMS NRDSYFYAAI VAVVAVHVVL ALFVYVAWNE GSRQWREGKQ

D
Length:101
Mass (Da):11,365
Last modified:July 5, 2004 - v1
Checksum:i5BDB68CC836190E1
GO
Isoform 2 (identifier: Q78T54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-101: GALGMSNRDS...SRQWREGKQD → ALRTKASLIDTLQLSSGRKKISPFRALQL

Note: No experimental confirmation available.
Show »
Length:83
Mass (Da):9,333
Checksum:i75E14FA57F836133
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z446F2Z446_MOUSE
Vacuolar ATPase assembly integral m...
Vma21 VMA21
120Annotation score:
F2Z447F2Z447_MOUSE
Vacuolar ATPase assembly integral m...
Vma21 VMA21
134Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03746455 – 101GALGM…EGKQD → ALRTKASLIDTLQLSSGRKK ISPFRALQL in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ748652 mRNA Translation: CAG38686.1
AK049296 mRNA Translation: BAC33664.1
AK049488 mRNA Translation: BAC33774.1
AK164163 mRNA Translation: BAE37657.1
AK138582 mRNA Translation: BAE23704.1
BC028317 mRNA Translation: AAH28317.1
BC094639 mRNA Translation: AAH94639.1
CCDSiCCDS41000.1 [Q78T54-1]
RefSeqiNP_001074825.1, NM_001081356.3 [Q78T54-1]
NP_001277710.1, NM_001290781.1
UniGeneiMm.371816
Mm.41102
Mm.487774

Genome annotation databases

EnsembliENSMUST00000114576; ENSMUSP00000110223; ENSMUSG00000073131 [Q78T54-1]
GeneIDi67048
KEGGimmu:67048
UCSCiuc009tkf.3 mouse [Q78T54-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVMA21_MOUSE
AccessioniPrimary (citable) accession number: Q78T54
Secondary accession number(s): Q3UUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again