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Protein

F-box only protein 22

Gene

Fbxo22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: MGI
  • nucleocytoplasmic transport Source: MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of ubiquitin-dependent protein catabolic process Source: MGI
  • protein polyubiquitination Source: MGI
  • regulation of myotube differentiation Source: MGI
  • regulation of skeletal muscle fiber development Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 22
Gene namesi
Name:Fbxo22
Synonyms:Fbx22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926014 Fbxo22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199071 – 402F-box only protein 22Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei193N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ78JE5
MaxQBiQ78JE5
PaxDbiQ78JE5
PeptideAtlasiQ78JE5
PRIDEiQ78JE5

PTM databases

iPTMnetiQ78JE5
PhosphoSitePlusiQ78JE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000032309
CleanExiMM_FBXO22
ExpressionAtlasiQ78JE5 baseline and differential
GenevisibleiQ78JE5 MM

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034859

Structurei

3D structure databases

ProteinModelPortaliQ78JE5
SMRiQ78JE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 70F-boxAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IQPW Eukaryota
ENOG4110X7S LUCA
GeneTreeiENSGT00390000013049
HOGENOMiHOG000285967
HOVERGENiHBG051570
InParanoidiQ78JE5
KOiK10302
OMAiCCKVGAS
OrthoDBiEOG091G08DL
PhylomeDBiQ78JE5
TreeFamiTF328809

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR019494 FIST_C
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF10442 FIST_C, 1 hit
SMARTiView protein in SMART
SM01204 FIST_C, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q78JE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGGGGGV SSSTDPRSTY VLSNLAEVVE RVFTFLPAKA LLRVAGVCRL
60 70 80 90 100
WRECVRRVLR THRSVTWISA GVAEAGHLEG HCLVRVVAEA LENVRILPQT
110 120 130 140 150
VLYMADSETF ISLEECRGHK RARKRTTMET ACALEKLFPK QCQVLGIVTP
160 170 180 190 200
GIVVTPMGSG SNRPQEIEIG ESGFALLFPQ IEGIKIQPFH FIKDSKNLTL
210 220 230 240 250
ERHQLTEVGL LDNPELRVVL VFGYNCCKVG ASNYLHRVVS TFSDMNIILA
260 270 280 290 300
GGQVDNLSSL TCEKNPLDID ATGVVGLSFS GHRIQSATVL LTEDVNDAKT
310 320 330 340 350
VEAAMQRLKA ANIPEQNTIG FMFACVGRGF QYYRAKGNVE ADAFRKFFPS
360 370 380 390 400
VPLFGFFGNG EIGCDRIVTG NFILRRCNEV KEEDLFHSYT TIMALVHLGT

SK
Length:402
Mass (Da):44,203
Last modified:March 15, 2005 - v2
Checksum:iA13037A4733583B7
GO

Sequence cautioni

The sequence AAH18273 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018273 mRNA Translation: AAH18273.1 Different initiation.
CCDSiCCDS23202.2
RefSeqiNP_082325.2, NM_028049.2
XP_006511522.1, XM_006511459.2
UniGeneiMm.276429
Mm.443874
Mm.487489

Genome annotation databases

EnsembliENSMUST00000034859; ENSMUSP00000034859; ENSMUSG00000032309
GeneIDi71999
KEGGimmu:71999
UCSCiuc009psc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFBX22_MOUSE
AccessioniPrimary (citable) accession number: Q78JE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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