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UniProtKB - Q78IQ7 (S39A4_MOUSE)
Protein
Zinc transporter ZIP4
Gene
Slc39a4
Organism
Mus musculus (Mouse)
Status
Functioni
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
1 PublicationGO - Molecular functioni
- zinc ion transmembrane transporter activity Source: MGI
GO - Biological processi
- cellular response to zinc ion starvation Source: MGI
- cellular zinc ion homeostasis Source: GO_Central
- zinc ion import across plasma membrane Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-442380, Zinc influx into cells by the SLC39 gene family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc transporter ZIP4Alternative name(s): Activated in W/Wv mouse stomach 2 Short name: mAWMS2 Solute carrier family 39 member 4 Zrt- and Irt-like protein 4 Short name: ZIP-4 |
Gene namesi | Name:Slc39a4 Synonyms:Zip4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919277, Slc39a4 |
VEuPathDBi | HostDB:ENSMUSG00000063354 |
Subcellular locationi
Endosome
- Recycling endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
Endosome
- recycling endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: MGI
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cytoplasmic vesicle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 337 | ExtracellularSequence analysisAdd BLAST | 315 | |
Transmembranei | 338 – 358 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 376 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 377 – 397 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 398 – 420 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 421 – 441 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 442 – 571 | CytoplasmicSequence analysisAdd BLAST | 130 | |
Transmembranei | 572 – 592 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 593 – 599 | ExtracellularSequence analysis | 7 | |
Transmembranei | 600 – 620 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 621 – 630 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 631 – 651 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 652 – 660 | ExtracellularSequence analysis | 9 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000042621 | 23 – 660 | Zinc transporter ZIP4Add BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 272 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 657 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q78IQ7 |
MaxQBi | Q78IQ7 |
PaxDbi | Q78IQ7 |
PRIDEi | Q78IQ7 |
ProteomicsDBi | 260784 [Q78IQ7-1] 260785 [Q78IQ7-2] |
PTM databases
GlyGeni | Q78IQ7, 4 sites |
iPTMneti | Q78IQ7 |
PhosphoSitePlusi | Q78IQ7 |
SwissPalmi | Q78IQ7 |
Expressioni
Tissue specificityi
Highly expressed in the small intestine and embryonic visceral yolk sac. Weakly expressed in the stomach and liver. Found to the apical surface of enterocytes and visceral endoderm cells during zinc deficiency.1 Publication
Inductioni
Up-regulated under conditions of dietary zinc deficiency. Down-regulated under conditions of dietary zinc excess.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000063354, Expressed in pineal body and 142 other tissues |
ExpressionAtlasi | Q78IQ7, baseline and differential |
Genevisiblei | Q78IQ7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073134 |
Miscellaneous databases
RNActi | Q78IQ7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 233 – 273 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 233 – 264 | Basic and acidic residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000160042 |
HOGENOMi | CLU_015114_12_0_1 |
InParanoidi | Q78IQ7 |
OMAi | FYLMETI |
OrthoDBi | 657777at2759 |
PhylomeDBi | Q78IQ7 |
TreeFami | TF318470 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR041137, ZIP4_N |
Pfami | View protein in Pfam PF02535, Zip, 1 hit PF18292, ZIP4_domain, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q78IQ7-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPKSVTQGL VLALLVGTVA VARPRNLLSL LALGQGALDR LELDGLLNTL
60 70 80 90 100
VARVHCTDGP CEKCLSVENV LALGKPDKPQ PAPESVLESR HIIYLSAAAA
110 120 130 140 150
LYLNNPEKTC KDIQAGLLAS HVDDYLATLE SPEAMTLGLS QLLQKIEAHA
160 170 180 190 200
ASQPTGEKTC VDLPQLLEEA EAAGVSKSAG LVLTALLDHV INGSCFQGLP
210 220 230 240 250
SPQYFVDFVF RLHSSDPPNI TLHELENLMH HLGVGGEDHS DHDDHGDHAD
260 270 280 290 300
HSHPDRKASH QDSELHTPHN SNSSVWDTLC LSAKDIMAVY GLSEEAGVSP
310 320 330 340 350
QAWAQLTPAL VQQQLSGACS PYPTIRIQDQ LSQTERYLYG SLATLLICLC
360 370 380 390 400
AVFGLLLLTC AKCSTATHYI MQTFLSLAVG ALTGDALLHL IPKVLGLHTH
410 420 430 440 450
GGEGHTHEEE VGVGGQATWR LLAVLGGFYI FFLFESFFNL LLPRDQDSEK
460 470 480 490 500
DGPCSHGGHS HGISLQLAPS NLRQSKQTHE SSRSDLVAEE TPELLNPETR
510 520 530 540 550
RLRAELRLLP YLITLGDAVH NFADGLAVGA AFSSSWKTGL ATSLAVFCHE
560 570 580 590 600
LPHELGDFAA LLHAGLSVKR ALLLNLASAL TAFAGLYVAL AVGVGEEGEA
610 620 630 640 650
WILAVATGLF LYVALCDMLP AMMNVRDQRP WLLFLLHNVG LLGGWTVLLL
660
LSLYEDNITF
Note: More abundant.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2U3TZ56 | A0A2U3TZ56_MOUSE | Zinc transporter ZIP4 | Slc39a4 | 607 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 431 – 435 | FFLFE → RPRVR (Ref. 4) Curated | 5 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015913 | 1 – 47 | Missing in isoform 2. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_015914 | 48 – 63 | NTLVA…GPCEK → MPGRLSLAQILSVCPQ in isoform 2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146977 mRNA Translation: BAE27581.1 AK147107 mRNA Translation: BAE27679.1 BC023498 mRNA Translation: AAH23498.1 AB052762 mRNA Translation: BAC53795.1 |
CCDSi | CCDS27578.1 [Q78IQ7-1] |
RefSeqi | NP_082340.1, NM_028064.2 [Q78IQ7-1] |
Genome annotation databases
Ensembli | ENSMUST00000230977; ENSMUSP00000155442; ENSMUSG00000063354 [Q78IQ7-1] |
GeneIDi | 72027 |
KEGGi | mmu:72027 |
UCSCi | uc007wlb.1, mouse [Q78IQ7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146977 mRNA Translation: BAE27581.1 AK147107 mRNA Translation: BAE27679.1 BC023498 mRNA Translation: AAH23498.1 AB052762 mRNA Translation: BAC53795.1 |
CCDSi | CCDS27578.1 [Q78IQ7-1] |
RefSeqi | NP_082340.1, NM_028064.2 [Q78IQ7-1] |
3D structure databases
SMRi | Q78IQ7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073134 |
PTM databases
GlyGeni | Q78IQ7, 4 sites |
iPTMneti | Q78IQ7 |
PhosphoSitePlusi | Q78IQ7 |
SwissPalmi | Q78IQ7 |
Proteomic databases
jPOSTi | Q78IQ7 |
MaxQBi | Q78IQ7 |
PaxDbi | Q78IQ7 |
PRIDEi | Q78IQ7 |
ProteomicsDBi | 260784 [Q78IQ7-1] 260785 [Q78IQ7-2] |
Protocols and materials databases
Antibodypediai | 28508, 226 antibodies from 32 providers |
DNASUi | 72027 |
Genome annotation databases
Ensembli | ENSMUST00000230977; ENSMUSP00000155442; ENSMUSG00000063354 [Q78IQ7-1] |
GeneIDi | 72027 |
KEGGi | mmu:72027 |
UCSCi | uc007wlb.1, mouse [Q78IQ7-1] |
Organism-specific databases
CTDi | 55630 |
MGIi | MGI:1919277, Slc39a4 |
VEuPathDBi | HostDB:ENSMUSG00000063354 |
Phylogenomic databases
eggNOGi | KOG2693, Eukaryota |
GeneTreei | ENSGT00940000160042 |
HOGENOMi | CLU_015114_12_0_1 |
InParanoidi | Q78IQ7 |
OMAi | FYLMETI |
OrthoDBi | 657777at2759 |
PhylomeDBi | Q78IQ7 |
TreeFami | TF318470 |
Enzyme and pathway databases
Reactomei | R-MMU-442380, Zinc influx into cells by the SLC39 gene family |
Miscellaneous databases
BioGRID-ORCSi | 72027, 2 hits in 63 CRISPR screens |
PROi | PR:Q78IQ7 |
RNActi | Q78IQ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063354, Expressed in pineal body and 142 other tissues |
ExpressionAtlasi | Q78IQ7, baseline and differential |
Genevisiblei | Q78IQ7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR041137, ZIP4_N |
Pfami | View protein in Pfam PF02535, Zip, 1 hit PF18292, ZIP4_domain, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S39A4_MOUSE | |
Accessioni | Q78IQ7Primary (citable) accession number: Q78IQ7 Secondary accession number(s): Q8CHL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families