UniProtKB - Q78EA7 (BMR1A_RAT)
Bone morphogenetic protein receptor type-1A
Bmpr1a
Functioni
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
By similarityCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 261 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 362 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 240 – 248 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: RGD
- BMP binding Source: RGD
- BMP receptor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- phosphatase activator activity Source: RGD
- protein homodimerization activity Source: RGD
- protein serine/threonine kinase activator activity Source: RGD
- protein serine/threonine kinase activity Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta receptor activity, type I Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: RGD
- atrioventricular node cell development Source: RGD
- atrioventricular valve development Source: RGD
- BMP signaling pathway Source: UniProtKB
- BMP signaling pathway involved in heart development Source: RGD
- cardiac conduction system development Source: RGD
- cardiac right ventricle morphogenesis Source: RGD
- cartilage development Source: RGD
- cell differentiation Source: RGD
- cellular response to BMP stimulus Source: RGD
- cellular response to growth factor stimulus Source: GO_Central
- chondrocyte differentiation Source: RGD
- developmental growth Source: RGD
- dorsal/ventral axis specification Source: RGD
- dorsal/ventral pattern formation Source: RGD
- dorsal aorta morphogenesis Source: RGD
- ectoderm development Source: RGD
- embryonic digit morphogenesis Source: RGD
- embryonic morphogenesis Source: RGD
- embryonic organ development Source: RGD
- endocardial cushion formation Source: RGD
- endocardial cushion morphogenesis Source: RGD
- endoderm development Source: RGD
- fibrous ring of heart morphogenesis Source: RGD
- heart development Source: RGD
- heart formation Source: RGD
- heart morphogenesis Source: RGD
- hindlimb morphogenesis Source: RGD
- immune response Source: RGD
- in utero embryonic development Source: RGD
- lateral mesoderm development Source: RGD
- lung development Source: RGD
- mesendoderm development Source: RGD
- mesoderm formation Source: RGD
- mitral valve morphogenesis Source: RGD
- Mullerian duct regression Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of muscle cell differentiation Source: RGD
- negative regulation of neurogenesis Source: RGD
- negative regulation of smooth muscle cell migration Source: RGD
- nervous system development Source: RGD
- neural crest cell development Source: RGD
- neural plate mediolateral regionalization Source: RGD
- neural plate pattern specification Source: RGD
- odontogenesis of dentin-containing tooth Source: RGD
- osteoblast differentiation Source: RGD
- outflow tract morphogenesis Source: RGD
- outflow tract septum morphogenesis Source: RGD
- paraxial mesoderm development Source: RGD
- paraxial mesoderm structural organization Source: RGD
- pattern specification process Source: RGD
- pharyngeal arch artery morphogenesis Source: RGD
- pituitary gland development Source: RGD
- positive regulation of bone mineralization Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of cardiac ventricle development Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- positive regulation of mesenchymal cell proliferation Source: RGD
- positive regulation of osteoblast differentiation Source: RGD
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: RGD
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- positive regulation of SMAD protein signal transduction Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transforming growth factor beta2 production Source: RGD
- positive regulation of vascular associated smooth muscle cell proliferation Source: RGD
- protein phosphorylation Source: RGD
- regulation of cardiac muscle cell proliferation Source: RGD
- regulation of cellular senescence Source: RGD
- regulation of lateral mesodermal cell fate specification Source: RGD
- roof of mouth development Source: RGD
- somitogenesis Source: RGD
- stem cell population maintenance Source: RGD
- tricuspid valve morphogenesis Source: RGD
- ventricular compact myocardium morphogenesis Source: RGD
- ventricular septum morphogenesis Source: RGD
- ventricular trabecula myocardium morphogenesis Source: RGD
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-201451, Signaling by BMP |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)Short name: BMP type-1A receptor Short name: BMPR-1A Alternative name(s): Activin receptor-like kinase 3 Short name: ALK-3 Bone morphogenetic protein 4 receptor CD_antigen: CD292 |
Gene namesi | Name:Bmpr1a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70989, Bmpr1a |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Other locations
- Cell surface By similarity
Plasma Membrane
- caveola Source: Ensembl
- external side of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- cell surface Source: UniProtKB
- dendrite Source: RGD
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: RGD
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 152 | ExtracellularSequence analysisAdd BLAST | 129 | |
Transmembranei | 153 – 176 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 177 – 532 | CytoplasmicSequence analysisAdd BLAST | 356 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000254907 | 24 – 532 | Bone morphogenetic protein receptor type-1AAdd BLAST | 509 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 61 ↔ 82 | By similarity | ||
Disulfide bondi | 63 ↔ 67 | By similarity | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 76 ↔ 100 | By similarity | ||
Disulfide bondi | 110 ↔ 124 | By similarity | ||
Disulfide bondi | 125 ↔ 130 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q78EA7 |
PRIDEi | Q78EA7 |
PTM databases
GlyGeni | Q78EA7, 1 site |
iPTMneti | Q78EA7 |
PhosphoSitePlusi | Q78EA7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000052469, Expressed in duodenum and 21 other tissues |
Genevisiblei | Q78EA7, RN |
Interactioni
Subunit structurei
Interacts with BMP2.
Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation.
Interacts with BMP4.
Interacts with SCUBE3.
By similarityGO - Molecular functioni
- BMP binding Source: RGD
- protein homodimerization activity Source: RGD
- SMAD binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249504, 1 interactor |
STRINGi | 10116.ENSRNOP00000015047 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 233 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 234 – 525 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 292 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 109 | Mediates specificity for BMP ligandBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156225 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | Q78EA7 |
OMAi | AINNTCQ |
OrthoDBi | 776697at2759 |
PhylomeDBi | Q78EA7 |
TreeFami | TF314724 |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
VRWLAVLISM AVCIVAMIVF SSCFCYKHYC KSISSRGRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT
410 420 430 440 450
RVGTRRYMAP EVLDESLSKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S75359 mRNA Translation: AAB33865.1 D38082 mRNA Translation: BAA07275.1 D17667 mRNA Translation: BAA04549.1 |
PIRi | JC2387 |
RefSeqi | NP_110476.1, NM_030849.1 XP_017455745.1, XM_017600256.1 |
Genome annotation databases
Ensembli | ENSRNOT00000079554; ENSRNOP00000074885; ENSRNOG00000052469 |
GeneIDi | 81507 |
KEGGi | rno:81507 |
UCSCi | RGD:70989, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S75359 mRNA Translation: AAB33865.1 D38082 mRNA Translation: BAA07275.1 D17667 mRNA Translation: BAA04549.1 |
PIRi | JC2387 |
RefSeqi | NP_110476.1, NM_030849.1 XP_017455745.1, XM_017600256.1 |
3D structure databases
BMRBi | Q78EA7 |
SMRi | Q78EA7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249504, 1 interactor |
STRINGi | 10116.ENSRNOP00000015047 |
PTM databases
GlyGeni | Q78EA7, 1 site |
iPTMneti | Q78EA7 |
PhosphoSitePlusi | Q78EA7 |
Proteomic databases
PaxDbi | Q78EA7 |
PRIDEi | Q78EA7 |
Genome annotation databases
Ensembli | ENSRNOT00000079554; ENSRNOP00000074885; ENSRNOG00000052469 |
GeneIDi | 81507 |
KEGGi | rno:81507 |
UCSCi | RGD:70989, rat |
Organism-specific databases
CTDi | 657 |
RGDi | 70989, Bmpr1a |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156225 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | Q78EA7 |
OMAi | AINNTCQ |
OrthoDBi | 776697at2759 |
PhylomeDBi | Q78EA7 |
TreeFami | TF314724 |
Enzyme and pathway databases
Reactomei | R-RNO-201451, Signaling by BMP |
Miscellaneous databases
PROi | PR:Q78EA7 |
Gene expression databases
Bgeei | ENSRNOG00000052469, Expressed in duodenum and 21 other tissues |
Genevisiblei | Q78EA7, RN |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BMR1A_RAT | |
Accessioni | Q78EA7Primary (citable) accession number: Q78EA7 Secondary accession number(s): Q64308 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families