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Protein

Jun dimerization protein 2

Gene

Jdp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:Jdp2
Synonyms:Jdp-2, Jundm2, Jundp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621611 Jdp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311321 – 163Jun dimerization protein 2Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei148Phosphothreonine; by MAPK8By similarity1

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.By similarity
Polyubiquitinated; probably by IRF2BP1.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ78E65

PTM databases

PhosphoSitePlusiQ78E65

Expressioni

Gene expression databases

BgeeiENSRNOG00000008224
GenevisibleiQ78E65 RN

Interactioni

Subunit structurei

Interacts with IRF2BP1 (By similarity). Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.By similarity2 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi250557, 1 interactor
STRINGi10116.ENSRNOP00000011339

Structurei

3D structure databases

ProteinModelPortaliQ78E65
SMRiQ78E65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 135bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 96Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni100 – 128Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110847
HOGENOMiHOG000034126
HOVERGENiHBG057870
InParanoidiQ78E65
KOiK09033
OMAiXESERLE
OrthoDBiEOG091G0M4N
PhylomeDBiQ78E65
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029819 JDP2
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF10 PTHR23351:SF10, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q78E65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE
160
SEGNPLLEQL DKK
Length:163
Mass (Da):18,675
Last modified:July 5, 2004 - v1
Checksum:iA8AB65A7D20564F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53449 mRNA Translation: AAC02258.1
RefSeqiNP_446346.1, NM_053894.1
UniGeneiRn.10721

Genome annotation databases

EnsembliENSRNOT00000011339; ENSRNOP00000011339; ENSRNOG00000008224
GeneIDi116674
KEGGirno:116674
UCSCiRGD:621611 rat

Similar proteinsi

Entry informationi

Entry nameiJDP2_RAT
AccessioniPrimary (citable) accession number: Q78E65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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