UniProtKB - Q78DX7 (ROS1_MOUSE)
Proto-oncogene tyrosine-protein kinase ROS
Ros1
Functioni
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2.
5 PublicationsCatalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1973 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 2072 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1944 – 1952 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein phosphatase binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB
- columnar/cuboidal epithelial cell development Source: UniProtKB
- gene expression Source: MGI
- negative regulation of gene expression Source: MGI
- peptidyl-tyrosine autophosphorylation Source: MGI
- positive regulation of kinase activity Source: GO_Central
- protein phosphorylation Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of phosphate transport Source: MGI
- regulation of TOR signaling Source: UniProtKB
- signal transduction Source: MGI
- spermatogenesis Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)Alternative name(s): Proto-oncogene c-Ros Proto-oncogene c-Ros-1 Receptor tyrosine kinase c-ros oncogene 1 c-Ros receptor tyrosine kinase |
Gene namesi | Name:Ros1 Synonyms:Ros, Ros-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97999, Ros1 |
VEuPathDBi | HostDB:ENSMUSG00000019893 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: MGI
- perinuclear region of cytoplasm Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 1854 | ExtracellularSequence analysisAdd BLAST | 1826 | |
Transmembranei | 1855 – 1875 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1876 – 2340 | CytoplasmicSequence analysisAdd BLAST | 465 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2267 | Y → F: Abrogates interaction with PTPN6. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneChemistry databases
ChEMBLi | CHEMBL2034802 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000278115 | 29 – 2340 | Proto-oncogene tyrosine-protein kinase ROSAdd BLAST | 2312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 362 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 935 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1011 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1676 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2267 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 2327 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q78DX7 |
PRIDEi | Q78DX7 |
ProteomicsDBi | 300468 |
PTM databases
GlyGeni | Q78DX7, 7 sites |
iPTMneti | Q78DX7 |
PhosphoSitePlusi | Q78DX7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000019893, Expressed in metanephros and 63 other tissues |
Genevisiblei | Q78DX7, MM |
Interactioni
Subunit structurei
Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway.
Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation (By similarity).
Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation.
By similarity1 PublicationGO - Molecular functioni
- protein phosphatase binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q78DX7, 2 interactors |
MINTi | Q78DX7 |
STRINGi | 10090.ENSMUSP00000020045 |
Chemistry databases
BindingDBi | Q78DX7 |
Miscellaneous databases
RNActi | Q78DX7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 206 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 207 – 295 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 567 – 667 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 943 – 1038 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1039 – 1146 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 1442 – 1549 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 1550 – 1649 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1651 – 1744 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 1745 – 1846 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1938 – 2216 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 279 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1095, Eukaryota |
GeneTreei | ENSGT00940000160831 |
HOGENOMi | CLU_000798_0_0_1 |
InParanoidi | Q78DX7 |
OMAi | SCKFGCS |
OrthoDBi | 203310at2759 |
PhylomeDBi | Q78DX7 |
TreeFami | TF351636 |
Family and domain databases
CDDi | cd00063, FN3, 8 hits |
Gene3Di | 2.120.10.30, 3 hits 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000033, LDLR_classB_rpt IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 9 hits SM00135, LY, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKNICWLTLK LVKFVVLGCI IWISVAQSTV LSSCLTSCVT NLGRQLDSGT
60 70 80 90 100
RYNLSEACIH GCQFWNSVDQ ETCALKCNDT YATICERESC EVGCSNAEGS
110 120 130 140 150
YEEEVLESTE LPTAPFASSI GSHGVTLRWN PANISGVKYI IQWKYAQLPG
160 170 180 190 200
SWTFTETVSK LSYTVEPLHP FTEYIFRVVW IFTAQLHLYS PPSPSYRTHP
210 220 230 240 250
YGVPETAPLI LNMESWSPDT VEVSWAPPHF PGGPILGYNL RLISKNQKLD
260 270 280 290 300
SGTQRTSFQF YSTLPNTTYR FSIAAVNEVG EGPEAESTVT TPSPSVQEEE
310 320 330 340 350
QWLFLSRKTS LRKRSLKYLV DEAHCLWSDA IHHNITGISV YAQQQVVYFS
360 370 380 390 400
EGTVIWMKGA ANMSDVSDLR IFYQGSGLVS SISIDWLYQR MYFIMDKLVY
410 420 430 440 450
VCELKNCSNL EEITPFSLIA PQKVVVDSYN GYLFYLLRDG IYRVNLPLPS
460 470 480 490 500
GRDTKAVRIV ESGTLKDFAV KPQSKRIIYF NDTMQLFMST FLDGSAFHRV
510 520 530 540 550
LPWVPLVTVK SFACENNDFL ITDGKAIFQQ DSLSFNEFIV GCDLSHIEEF
560 570 580 590 600
GFGNLVIFGS SVQSYPLPGH PQEVSVLFGS REALIQWTPP ALAIGASPSA
610 620 630 640 650
WQNWTYEVKV YSQDILEITQ VFSNISGTML NVPELQSSTK YTVSVRASSP
660 670 680 690 700
KGPGPWSAPS VGTTLVPATE PPFIMAVKED GLWSKPLCSF GPGEFLSSDV
710 720 730 740 750
GNVSDMDWYN NSLYYSDTKG NVYVRPLNGM DISENYHIPS IVGAGALAFE
760 770 780 790 800
WLGHFLYWAG KTYVIQRQSV LTGHTDIVTH VKLLVNDMAV DSVGGYLYWT
810 820 830 840 850
TLYSVESTRL NGESSLVLQA QPWLSGKKVI ALTLDLSDGL LYWLVQDNQC
860 870 880 890 900
IHLYTAVLRG WSGGDATITE FAAWSTSEIS QNALMYYSGR LFWINGFRII
910 920 930 940 950
TAQEIGQRTS VSVSEPAKFN QFTIIQTSLK PLPGNFSSTP KVIPDPVQES
960 970 980 990 1000
SFRIEGHTSS FQILWNEPPA VDWGIVFYSV EFSTHSKFLI IEQQSLPIFT
1010 1020 1030 1040 1050
VEGLEPYTLF NLSVTPYTYW GKGQKTSLSF RAPESVPSAP ENPRIFILSS
1060 1070 1080 1090 1100
GRYTKKNEVV VEFRWNKPKH ENGVLTKFEI FYHISKQSGT NRSTEDWMSA
1110 1120 1130 1140 1150
SVIPPVMSFQ LEAVSPEYTV AFQVRVFTSK GPGPFSDIVM SKTSEIKPCP
1160 1170 1180 1190 1200
YLISLLGNKI VFLDMDQNQV LWTFSLEGDV STVGYTTDDE MGYFAQGDTL
1210 1220 1230 1240 1250
FLLNLRNHSS SKLFQDALVS DIRVIAVDWI ARHLYFALKA SQNGTQIFNV
1260 1270 1280 1290 1300
DLEHKVKSPR EVKTCKAHTT IISFSIYPLL SRLYWTEVSD LGHQMFYCNI
1310 1320 1330 1340 1350
SNHTSQHVLQ PKASNQHGRS QCSCNVTESE LSGAMTVDTS DPDRPWIYFT
1360 1370 1380 1390 1400
KRQEIWAMDL EGCQCWKVIM VPTIPGKRII SLTVDGEFIY WIMKTKDDAQ
1410 1420 1430 1440 1450
IYQAKKGSGA ILSQVKASRS KHILAYSSAL QPFPDKAYLS LASDMVEATI
1460 1470 1480 1490 1500
LYATNTSLTL KLPPVKTNLT WHGITHPTST YLIYYMEANR ANSSDRRHKM
1510 1520 1530 1540 1550
LESQENVARI EGLQPFSMYM IQIAVKNYYS EPLEHLPLGK EIQGQTKSGV
1560 1570 1580 1590 1600
PGAVCHINAT VLSDTSLHVF WTESHKPNGP KESVRYQLVM SYLAPIPETP
1610 1620 1630 1640 1650
LRQGEFPSAK LSLLITKLSG GQLYVMKVLA CHPEEMWCTE SHPVSVNMFD
1660 1670 1680 1690 1700
TPEKPSALVP ENTSLQLDWK ARSNVNLTGF WFELQKWKYN EFYHVKASCS
1710 1720 1730 1740 1750
QGPVYVCNIT DLQPYTSYNI RVVVVYTTGE NSSSIPESFK TKAGVPSKPG
1760 1770 1780 1790 1800
IPKLLEGSKN SIQWEKAEDN GSRLMYYTLE VRKGISNDSQ NQSSRWKVVF
1810 1820 1830 1840 1850
NGSCSSICTW RSKNLKGTFQ FRAVAANEIG LGEYSEISED ITLVEDGVWI
1860 1870 1880 1890 1900
TETSFILTII VGIFLVATVP LTFVWHRSLK SHKASKEGLS VLNDNDKELA
1910 1920 1930 1940 1950
ELRGLAAGVG LANACYAVHT VPTQEEIENL PAFPREKLSL RLLLGSGAFG
1960 1970 1980 1990 2000
EVYEGTAIDI LGVGSGEIKV AVKTLKKGST DQEKIEFLKE AHLMSKFNHP
2010 2020 2030 2040 2050
NILKQLGVCL LGEPQYIILE LMEGGDLLSY LRKARGTTFH GPSLTLLDLV
2060 2070 2080 2090 2100
ELCVDISKGC VYLEQMHFIH RDLAARNCLV SVKDYTSPRV VKIGDFGLAR
2110 2120 2130 2140 2150
EIYKNDYYRK RGEGLLPVRW MAPENLMDGI FTSQSDVWSF GILVWEILTL
2160 2170 2180 2190 2200
GHQPYPAHSN LDVLNYVQAG GRLEPPRNCP DDLWNLMSQC WAQEPDQRPT
2210 2220 2230 2240 2250
FHNIQNQLQL FRNVFLNNVS HCGEAAPTGG VINKGFEGED DEMVTLNSDD
2260 2270 2280 2290 2300
TMPVALMETK NQEGLNYMVL ATKCSQGEGS YEGPLGPKEL GSCDLKKDKK
2310 2320 2330 2340
QPQADKDFCQ EPQVAYGSPG LSEGLNYACL AHSEHGDVSE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7L6 | A0A1W2P7L6_MOUSE | Receptor protein-tyrosine kinase | Ros1 | 2,319 | Annotation score: | ||
A0A1W2P7C6 | A0A1W2P7C6_MOUSE | Proto-oncogene tyrosine-protein kin... | Ros1 | 1,855 | Annotation score: | ||
A0A1W2P858 | A0A1W2P858_MOUSE | Proto-oncogene tyrosine-protein kin... | Ros1 | 544 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | Q → L in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 109 – 111 | TEL → QAI in AAA50600 (PubMed:8544427).Curated | 3 | |
Sequence conflicti | 329 | D → Y in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 419 | I → V in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 591 | A → P in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 595 | G → P in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 631 – 632 | NV → KL in AAA50600 (PubMed:8544427).Curated | 2 | |
Sequence conflicti | 642 – 645 | TVSV → PFSC in AAA50600 (PubMed:8544427).Curated | 4 | |
Sequence conflicti | 656 | W → G in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 671 – 672 | PP → LL in AAA50600 (PubMed:8544427).Curated | 2 | |
Sequence conflicti | 830 | I → V in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1050 | S → R in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1066 | N → D in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1085 | S → F in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1235 | Y → C in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1276 | I → T in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1371 | V → L in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1428 – 1429 | SA → FR in AAA50600 (PubMed:8544427).Curated | 2 | |
Sequence conflicti | 1486 – 1487 | ME → IK in AAA50600 (PubMed:8544427).Curated | 2 | |
Sequence conflicti | 1541 – 1545 | EIQGQ → RFKDK in AAA50600 (PubMed:8544427).Curated | 5 | |
Sequence conflicti | 1585 – 1592 | RYQLVMSY → AISWLMSD in AAA50600 (PubMed:8544427).Curated | 8 | |
Sequence conflicti | 1669 | W → R in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1778 | T → S in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1893 | N → S in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 1917 – 1918 | AV → GI in AAA50600 (PubMed:8544427).Curated | 2 | |
Sequence conflicti | 2087 | S → N in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 2118 | V → A in AAA50600 (PubMed:8544427).Curated | 1 | |
Sequence conflicti | 2270 – 2272 | LAT → VPQ in AAA50600 (PubMed:8544427).Curated | 3 | |
Sequence conflicti | 2333 | S → R in AAA50600 (PubMed:8544427).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81650 mRNA Translation: CAA57310.1 U15443 mRNA Translation: AAA50600.1 |
CCDSi | CCDS23838.1 |
RefSeqi | NP_035412.2, NM_011282.2 |
Genome annotation databases
Ensembli | ENSMUST00000020045; ENSMUSP00000020045; ENSMUSG00000019893 |
GeneIDi | 19886 |
KEGGi | mmu:19886 |
UCSCi | uc007fbb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81650 mRNA Translation: CAA57310.1 U15443 mRNA Translation: AAA50600.1 |
CCDSi | CCDS23838.1 |
RefSeqi | NP_035412.2, NM_011282.2 |
3D structure databases
AlphaFoldDBi | Q78DX7 |
SMRi | Q78DX7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q78DX7, 2 interactors |
MINTi | Q78DX7 |
STRINGi | 10090.ENSMUSP00000020045 |
Chemistry databases
BindingDBi | Q78DX7 |
ChEMBLi | CHEMBL2034802 |
PTM databases
GlyGeni | Q78DX7, 7 sites |
iPTMneti | Q78DX7 |
PhosphoSitePlusi | Q78DX7 |
Proteomic databases
PaxDbi | Q78DX7 |
PRIDEi | Q78DX7 |
ProteomicsDBi | 300468 |
Protocols and materials databases
Antibodypediai | 32541, 670 antibodies from 35 providers |
DNASUi | 19886 |
Genome annotation databases
Ensembli | ENSMUST00000020045; ENSMUSP00000020045; ENSMUSG00000019893 |
GeneIDi | 19886 |
KEGGi | mmu:19886 |
UCSCi | uc007fbb.1, mouse |
Organism-specific databases
CTDi | 6098 |
MGIi | MGI:97999, Ros1 |
VEuPathDBi | HostDB:ENSMUSG00000019893 |
Phylogenomic databases
eggNOGi | KOG1095, Eukaryota |
GeneTreei | ENSGT00940000160831 |
HOGENOMi | CLU_000798_0_0_1 |
InParanoidi | Q78DX7 |
OMAi | SCKFGCS |
OrthoDBi | 203310at2759 |
PhylomeDBi | Q78DX7 |
TreeFami | TF351636 |
Miscellaneous databases
BioGRID-ORCSi | 19886, 2 hits in 75 CRISPR screens |
ChiTaRSi | Ros1, mouse |
PROi | PR:Q78DX7 |
RNActi | Q78DX7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019893, Expressed in metanephros and 63 other tissues |
Genevisiblei | Q78DX7, MM |
Family and domain databases
CDDi | cd00063, FN3, 8 hits |
Gene3Di | 2.120.10.30, 3 hits 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000033, LDLR_classB_rpt IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 9 hits SM00135, LY, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ROS1_MOUSE | |
Accessioni | Q78DX7Primary (citable) accession number: Q78DX7 Secondary accession number(s): Q60705 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families